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40 Possible Causes for Trilineage Dysplasia

  • Acute Myeloid Leukemia with Multilineage Dysplasia

    A 35-year-old man was diagnosed as having de novo AML with multilineage dysplasia because of 30% myeloperoxidase-positive blasts and trilineage dysplasia in the bone marrow[ncbi.nlm.nih.gov] Allogeneic bone marrow transplantation improves the outcome of de novo AML with trilineage dysplasia (AML-TLD). Leukemia . 2000;14:1861–1866.[link.springer.com] dysplasia (AML-TLD), as well as in patients with treatment-induced MDS, CMMoL (dysplastic) and AML-TLD.[clinicaltrials.gov]

  • Acute Myelocytic Leukemia

    These two cases of acute leukemia, which developed 3 years after diagnosis of breast cancer and initiation of chemotherapy, were characterized by trilineage dysplasia and[ncbi.nlm.nih.gov] Dysplasia was not found to be an independent prognostic parameter, but the detection of trilineage dysplasia correlated with unfavorable cytogenetics.[ncbi.nlm.nih.gov]

  • Refractory Anemia with Excess Blasts

    dysplasia.[ncbi.nlm.nih.gov] […] diagnosed MD-CMML patients, showed some significant differences in Hb level, platelet count, percentage of immature circulating precursor (IPC), bone marrow blastosis and trilineage[ncbi.nlm.nih.gov]

  • T-Cell Lymphoblastic Lymphoma

    Bone marrow examination showed trilineage dysplasia with no evidence of lymphoma cells.[ncbi.nlm.nih.gov]

  • Acute Erythremia

    This may be explained by the high frequency of bi- or trilineage dysplasia and abnormal cytogenetic findings in this group.[doi.org] The prominent, often trilineage dysplasia, frequent ring sideroblasts, cytopenias, and lack of class I mutations suggest a relationship of AEL to MDS.[doi.org] Dyserythropoiesis was observed in 30 of 31 (97%) cases evaluated, and was present in all 12 (39%) cases of trilineage dysplasia, in 11 (29%) cases of bilineage dysplasia,[doi.org]

  • Jeune Syndrome

    dysplasia and clonal cytogenetic abnormalities on bone marrow examination.[ncbi.nlm.nih.gov] […] progressive pancytopenia but was only diagnosed with SDS at 11 years of age after referral for haematopoietic stem cell transplantation for bone marrow failure accompanied by trilineage[ncbi.nlm.nih.gov]

  • Thrombocytosis

    A trilineage dysplasia suggests the myelodysplastic syndrome, and intense marrow cellularity with florid atypical megakaryocytic hyperplasia suggests "cellular phase" myeloid[enotes.tripod.com] Similarly, bone marrow histology should be carefully scrutinized for the presence of both trilineage dysplasia—which would suggest myelodysplastic syndromes—and intense marrow[ascopost.com]

  • Acute Erythroblastic Leukemia

    This may be explained by the high frequency of bi- or trilineage dysplasia and abnormal cytogenetic findings in this group.[doi.org] Trilineage dysplasia is common but is not a prerequisite for diagnosis. Erythroid dysplasia may manifest as binuclearity, nucleocytoplasmic asynchrony and vacuolation.[atlasgeneticsoncology.org] The prominent, often trilineage dysplasia, frequent ring sideroblasts, cytopenias, and lack of class I mutations suggest a relationship of AEL to MDS.[doi.org]

  • Pancytopenia

    These showed trilineage hypoplasia and prominent dysplasia (see inset panel, arrows), including multiple vacuolated myeloid precursors (see large panel, arrows).[bloodjournal.org] Patients with MMA and other organic acidemias can develop bone marrow hypoplasia and trilineage dysplasia during metabolic crises, a phenomenon that has been described in[bloodjournal.org]

  • Myelodysplasia

    Associated diseases Chronic myelomonocytic leukaemia (monocytosis with 1,000 cells/μl and trilineage dysplasia) appears to be an overlap condition between MDS and myeloproliferative[patient.info] When MDS patients develop more than 20 percent blast cells, they are reclassified as having acute myelogenous leukemia (AML) with trilineage dysplasia (AML-TLD).[hopkinsmedicine.org]

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