Triphalangeal Thumbs: Causes & Reasons

Possible Causes for Triphalangeal Thumbs

Diagnosis Absent, bifid, hypoplastic, or triphalangeal thumb associated with cardiac septation defects, classically atrial septal defect (often with conduction defects), but [accesspediatrics.mhmedical.com]

Can be very variable ranging from absent or triphalangeal thumbs to radial ray defects or phocomelia. Other milder features may include restricted supination. [genetics4medics.com]

The manifestations of the limb defects may vary in severity from subtle carpal bone defects and triphalangeal thumb to digit aplasia and upper extremity phocomelia. [ncbi.nlm.nih.gov]

Fitzsimmons-McLachlan-Gilbert Syndrome

thumbs duplication Familial partial epilepsy with variable focus Familial periodic paralysis Familial polyposis Familial porencephaly Familial supernumerary nipples Familial [academickids.com]

[…] fever Familial multiple lipomatosis Familial multiple trichodiscomas Familial myelofibrosis Familial nasal acilia Familial non-immune hyperthyroidism Familial opposable triphalangeal [bionity.com]

[…] m-Familial w Familial Mediterranean fever Familial multiple trichodiscomas Familial myelofibrosis Familial nasal acilia Familial non-immune hyperthyroidism Familial opposable triphalangeal [academickids.com]

Polydactyly

thumbs, J Hand Surg Br Vol, 1998 ^ a b c Qazi Q, Kassner EG, Triphalangeal thumb, J Med Genet, 1988 ^ Heutink P, Zguricas J, et al., The gene for triphalangeal thumb maps [en.wikipedia.org]

Varies from extra phalanx to complete hypoplastic thumb May cause broadening of distal phalanx to triphalangeal thumb More common in males, most often unilateral, usually [en.wikibooks.org]

Thalidomide ingestion can result in triphalangeal thumb polydactyly. [dermatologyadvisor.com]

Acro-Pectoral Syndrome

The mapping showed that the acropectoral locus was in a region where preaxial polydactyly and triphalangeal thumb-polysyndactyly had previously been mapped. [monsterologist.blogspot.com]

thumb), preaxial polydactyly type III (PPD3, OMIM 174600, characterised by duplication of a non-opposable triphalangeal index finger), and triphalangeal thumb-polysyndactyly [jmg.bmj.com]

[…] to duplication of an entire biphalangeal or triphalangeal thumb, in two cases with an associated extra metacarpal, lying in a soft tissue web between the thumb and index [monsterologist.blogspot.com]

Tel Hashomer Camptodactyly Syndrome

thumb non opposable Triphalangeal thumb polysyndactyly syndrome Triphalangeal thumbs brachyectrodactyly Triple A syndrome Triplo X Syndrome Triploid Syndrome Triploidy Trismus [bioreference.net]

thumb non opposable Triphalangeal thumb polysyndactyly syndrome Triphalangeal thumbs brachyectrodactyly Triple A syndrome Triplo X Syndrome Triploid Syndrome Triploidy Tris [ipfs.io]

Triphalangeal thumb non opposable[?] Triphalangeal thumb polysyndactyly syndrome[?] Triphalangeal thumbs brachyectrodactyly[?] Triple A syndrome[?] Triplo X Syndrome[?] [encyclopedia.kids.net.au]

Congenital Hypoplastic Anemia

[…] meant to denote 3 phalanges (finger bones) in the thumb, as against 2 phalanges in a normally developed thumb The presence of both congenital hypoplastic anemia and triphalangeal [dovemed.com]

Associated phenotypic abnormalities such as triphalangeal thumbs and cleft lip and/or palate are found in 70% of cases. [ncbi.nlm.nih.gov]

Thumb abnormalities, including flattening of the thenar eminence and triphalangeal thumb, may be bilateral or unilateral. The radial pulse may be absent. [clinicalgate.com]

Central Polydactyly of Fingers

Thalidomide ingestion can result in triphalangeal thumb polydactyly. [dermatologyadvisor.com]

The thumb may have 3 bones instead of two, this is called a triphalangeal thumb. [sickkids.ca]

This anomaly should not be confused with the triphalangeal thumb. [boneandspine.com]

Adactyly of Foot

Disease Type of connection Adactyly of foot, unilateral Hypoplastic tibiae - postaxial polydactyly Polydactyly of a triphalangeal thumb, bilateral Polydactyly of a triphalangeal [csbg.cnb.csic.es]

X-ray of the hands showed triphalangeal thumbs (Fig. 2). [indianpediatrics.net]

X -ray of the hands showed triphalangeal thumbs ( Fig. 2 ). [indianpediatrics.net]

Congenital Pseudoarthrosis of Clavicle

[…] and toe syndrome Supernumerary metacarpal bone Thin clavicle Triphalangeal thumb Triphalangeal thumb Triphalangeal thumb and dislocation of patella syndrome Triphalangeal [icdlist.com]

Triphalangeal thumb (Q74.0) Sprengel's deformity (congenital) (Q74.0) Macrodactylia, macrodactylism (fingers) (thumbs) (Q74.0) Megalodactylia (fingers) (thumbs) (congenital [icd.codes]

thumb The following code(s) above Q74.0 contain annotation back-references Annotation Back-References In this context, annotation back-references refer to codes that contain [icd10data.com]

Central Polydactyly of Toes

The thumb may have 3 bones instead of two, this is called a triphalangeal thumb. [sickkids.ca]

This anomaly should not be confused with the triphalangeal thumb. [boneandspine.com]

thumb (in one or both of the thumbs at any level) 20% Wladimiroff JW, Stewart PA, Reuss A et.al. [fetalultrasound.com]

Polydactyly of a Biphalangeal Thumb

Polydactyly and the triphalangeal thumb Polydactyly associated with triphalangeal thumb is not rare, as among the records of 1,269 patients with congenital deformation of [docslide.net]

thumbs, J Hand Surg Br Vol, 1998 ^ a b c Qazi Q, Kassner EG, Triphalangeal thumb, J Med Genet, 1988 ^ Heutink P, Zguricas J, et al., The gene for triphalangeal thumb maps [en.wikipedia.org]

Triphalangeal thumb two-thirds of the patients with triphalangeal thumbs, for triphalangeal thumb maps to the subtelomeric region of chromosome. [wgwkren1df.host22.com]

Crossed Polysyndactyly

Thumb polydactyly and polydactyly of triphalangeal thumb are discussed under subsequent headings in this chapter. [rrnursingschool.biz]

Preaxial type II: triphalangeal thumb polydactyly (TPT) (OMIM-174500) The biphalangeal thumb is replaced by a triphalangeal thumb (TPT) (Fig. 1B). [myslide.es]

thumb. [nature.com]

Oculootoradial Syndrome

Triphalangeal thumbs also occur in a number of syndromes. [rrnursingschool.biz]

Triphalangeal thumb is considered a form of pre-axial polydactyly. Epidemiology Triphalangeal thumbs have an incidence of 1 in 25,000 7. [radiopaedia.org]

Thumb involvement is the most typical clinical manifestation and can range from absence or hypoplasia to the presence of a triphalangic thumb. [rarediseases.info.nih.gov]

Diamond-Blackfan Anemia Type 2

Physical examination is notable for conjunctival pallor, hypertelorism, and triphalangeal thumbs. [step2.medbullets.com]

Clinical features: Triphalangeal thumb Supernumerary thumbs Craniofacial dysmorphism (snub nose, wide set eyes, think upper lip) Short stature Labs: Low hemoglobin level Low [medicowesome.com]

[…] abrnormalities triphalangeal thumb Studies Serum labs isolated macrocytic anemia white blood cells and platelets are typically normal reticulocytopenia elevated hemoglobin [step2.medbullets.com]

Retinohepatoendocrinologic Syndrome

Rabson-Mendenhall syndrome Radial defect Robin sequence Radial hypoplasia, triphalangeal thumbs and hypospadias Radial ray hypoplasia choanal atresia Radiation induced angiosarcoma [mindmappedia.com]

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Rabies Rabson-Mendenhall syndrome Radial defect Robin sequence Radial hypoplasia, triphalangeal thumbs and hypospadias [fact-index.com]

Ra Rab-Rai Rabies Rabson-Mendenhall syndrome Radial defect Robin sequence Radial hypoplasia, triphalangeal thumbs and hypospadias Radial ray agenesis Radial ray hypoplasia [ssf.f15ijp.com]

Postaxial Oligodactyly, Tetramelic

thumb Opposable triphalangeal thumb Limb duplication Premature atrial contractions Absent tibia Preaxial foot polydactyly Abnormality of the nose Short foot Abnormality of [mendelian.co]

Congenital Limb Deficiency Disorders and thumb hypoplasia may have a parent with only mild thumb hypoplasia or a triphalangeal thumb). [docksci.com]

[…] syndrome Trigonocephaly-short stature-developmental delay syndrome Triphalangeal thumb-polysyndactyly syndrome Triphalangeal thumbs-brachyectrodactyly syndrome Trismus-pseudocamptodactyly [se-atlas.de]

Preaxial Polydactyly Type 4

and may not be the full list of triphalangeal thumb - polysyndactyly syndrome signs or triphalangeal thumb - polysyndactyly syndrome symptoms. [medigoo.com]

We studied a large Indian pedigree (UR002) with an autosomal dominant triphalangeal thumb (TPT) and polysyndactyly (PSD). [archive-ouverte.unige.ch]

Triphalangeal thumb–polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer M Sun 1, F Ma 1, [jmg.bmj.com]

Facioauriculoradial Dysplasia

thumb-hypospadias-maxillary diastema • Radial ray aplasia-renal anomalies • Radial ray deficiency, X-linked • Radial ray hypoplasia, isolated form • Radio-digito-facial dysplasia [rrnursingschool.biz]

Congenital Limb Deficiency Disorders and thumb hypoplasia may have a parent with only mild thumb hypoplasia or a triphalangeal thumb). [docksci.com]

The radial defects observed with less frequency were thumb agenesis, preaxial polydactyly, and triphalangeal thumb. [5] In our case left-side preaxial polydactyly was observed [jfmpc.com]

Hemimelia

thumb syndrome is a distinct congenital limb anomaly complex, whose association with the 404 G>A mutation in a distant sonic hedgehog cis-regulator (ZRS) was suggested. [ncbi.nlm.nih.gov]

The tibial hemimelia is usually described with preaxial mirror polydactyly, split hand/foot syndrome-ectrodactyly, polydactyly-triphalangeal thumb syndrome (Werner syndrome [ncbi.nlm.nih.gov]

J Bone Joint Surg Br 60(1):31–39 Article CAS Google Scholar Kantaputra PN, Chalidapong P (2000) Are triphalangeal thumb–polysyndactyly syndrome (TPTPS) and tibial hemimelia–polysyndactyly–triphalangeal [nature.com]

Nager Syndrome

Limb defects typically involve the anterior (radial) elements of the upper limbs and manifest as small or absent thumbs, triphalangeal thumbs, radial hypoplasia or aplasia [ncbi.nlm.nih.gov]

Triphalangeal thumbs and other abnormalities of the digits have also been reported and a small percentage of patients also have lower limb malformations. [orpha.net]

[…] deviation of finger Short toe Toe syndactyly Triphalangeal thumb Abnormality of prenatal development or birth Premature birth Abnormality of the cardiovascular system Patent [ncbi.nlm.nih.gov]

Thoracomelic Dysplasia

Thumb, Nonopposable OMIM:190650 Triphalangeal Thumbs and Dislocation of Patella OMIM:190680 Triphalangeal Thumbs with Brachyectrodactyly OMIM:190500 Triphalangeal Thumb with [informatics.jax.org]

Triphalangeal thumbs Epilepsy EBS-MP familial Joint laxity Osteoectasia familial thrombocytopathy deafness Epilepsy benign neonatal with Ehlers-danlos syndrome type 11 familial [yumpu.com]

Congenital Absence of both Forearm and Hand

J Hered 53: 259–265 Google Scholar Wood VE (1976) Treatment of the triphalangeal thumb. [link.springer.com]

Triphalangeal thumb  AD  Extra phalanx of variable size, variable shape(triangular/trapezoid/rectangular) normal appearing thumb  Fully developed extra phalanx lying in [slideshare.net]

Preaxial polydactyly, especially triphalangeal thumb, is most likely to be part of a multisystem syndrome. [sonoworld.com]

Tricho-Retino-Dento-Digital Syndrome

thumb non opposable Triphalangeal thumb polysyndactyly syndrome Triphalangeal thumbs brachyectrodactyly Trismus pseudocamptodactyly syndrome Trophoblastic Neoplasms (gestational [mindmappedia.com]

thumb non opposable Triphalangeal thumb polysyndactyly syndrome Triphalangeal thumbs brachyectrodactyly Triple A syndrome Triplo X Syndrome Triploid Syndrome Triploidy Tris [wikidoc.org]

[…] defect polydactyly Trihydroxycholestanoylcoa oxidase isolated deficiency Trimethadione antenatal infection Trimethylaminuria Triopia Triosephosphate isomerase deficiency Triphalangeal [ipfs.io]

Humero-Radial Synostosis

thumb The following code(s) above Q74.0 contain annotation back-references Annotation Back-References In this context, annotation back-references refer to codes that contain [icd10data.com]

Radial-ulnar (anterior-posterior) axis iii…Radial polydactyly iv…Triphalangeal thumb vi…Ulnar polydactyly 4. [trialregister.nl]

Thoracolaryngopelvic Dysplasia

[…] dysplasia Tricyclic antidepressant overdose Trig–Trip[edit] Trigeminal neuralgia Trigger finger Trigonocephaly Trigonocephaly bifid nose acral anomalies Trigonocephaly broad thumbs [sosu.us]

Pseudoaminopterin Syndrome

Keywords Cleft Palate Roberts Syndrome Acrofacial Dysostosis Triphalangeal Thumb Thalidomide Embryopathy These keywords were added by machine and not by the authors. [link.springer.com]

thumbs duplication Familial partial epilepsy with variable focus Familial periodic paralysis Familial polyposis Familial porencephaly Familial supernumerary nipples Familial [bionity.com]

thumb non opposable Triphalangeal thumb polysyndactyly syndrome Triphalangeal thumbs brachyectrodactyly Triple A syndrome Triplo X Syndrome Triploid Syndrome Triploidy Tris [sosu.us]

Congenital Absence of Upper Arm and Forearm with Hand Present

J Hered 53: 259–265 Google Scholar Wood VE (1976) Treatment of the triphalangeal thumb. [link.springer.com]

Triphalangeal thumb  AD  Extra phalanx of variable size, variable shape(triangular/trapezoid/rectangular) normal appearing thumb  Fully developed extra phalanx lying in [slideshare.net]

Preaxial polydactyly, especially triphalangeal thumb, is most likely to be part of a multisystem syndrome. [sonoworld.com]

Humerus Trochlea Aplasia

Type VII : complete double thumb, in which one of the split thumbs has three phalanges (triphalangeal thumb) (20 %) (Redrawn from: Wassel HD. [obgynkey.com]

thumb Ulnar polydactyly Dorsal-ventral axis Dorsal dimelia (palmar nail) Hypoplastic/aplastic nail Failure of handplate formation/differentiation—unspecified axis Soft tissue [radiologykey.com]

thumbs duplication Familial partial epilepsy with variable focus Familial periodic paralysis Familial polyposis Familial porencephaly Familial supernumerary nipples Familial [sosu.us]

Spondylo-Megaepiphyseal-Metaphyseal Dysplasia

Endocrine and metabolic disease hsa04141 Protein processing in endoplasmic reticulum H00855 Triphalangeal thumb-polysyndactyly syndrome Triphalangeal thumb (TPT) is a rare [kegg.jp]

[…] group This includes the following conditions: Preaxial polydactyly (multiple types) Postaxial polydactyly Triphalangeal thumb Greig cephalopolysyndactyly syndrome Pallister-Hall [emedicine.medscape.com]

thumb Pallister-Hall Syndrome Synpolydactyly Synpolydactyly 2 Townes-Brocks syndrome Acrocallosal syndrome Proximal symphalangism Radioulnar synostosis with amegakaryocytic [csirnotes.com]

Congenital Deformities of Limbs

Preaxial polydactyly, especially triphalangeal thumb, is most likely to be part of a multisystem syndrome. [sonoworld.com]

AASE - triphalangeal thumb with congenital anaemia: A congenital erythroid hypoplastic anaemia is associated with triphalangeal thumbs which lie in the same plane as the other [oandplibrary.org]