Trophoblastic Cells: Causes & Reasons

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Possible Causes for Trophoblastic Cells

Hydatidiform Mole

These results suggest that these cells exhibit characteristics of trophoblastic cells, especially cytotrophoblastic cells. [ncbi.nlm.nih.gov]

Hydatidiform mole (molar pregnancy) is a benign tumor of placental trophoblastic cells, which release human chorionic gonadotropin (hCG). [ncbi.nlm.nih.gov]

Furthermore, we discovered miR-21 was significantly increased in JAR and JEG-3 cells compared with normal primary human trophoblastic cells. [ncbi.nlm.nih.gov]

Choriocarcinoma

cell lines. [ncbi.nlm.nih.gov]

Furthermore, we discovered miR-21 was significantly increased in JAR and JEG-3 cells compared with normal primary human trophoblastic cells. [ncbi.nlm.nih.gov]

Cell apoptosis serves a role in the progression from hydatidiform mole to persistent gestational trophoblastic disease. [ncbi.nlm.nih.gov]

Invasive Hydatidiform Mole

(βhCG) Rare Epithelioid trophoblastic tumor (ETT) Chorionic-type extravillous trophoblastic cells in the chorion laeve Variant of PSTT – clinical behavior similar to PSTT [arupconsult.com]

Sheets of anaplastic trophoblastic cells are noted without the maintenance of the pattern of the villi. Extensive necrosis is evident. Back to Top [glowm.com]

General Information About Gestational Trophoblastic Disease Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside [northshore.org]

Testicular Embryonal Carcinoma

Abstract Hyperglycosylated human chorionic gonadotropin (hCG-H), a variant of hCG, has been shown to promote the growth and invasion of trophoblast cells in early pregnancy [digitalrepository.unm.edu]

[…] teratoma (91023) Embryonal carcinoma (90703; also called embryonal cell carcinoma—poorer prognosis) Teratocarcinoma (90813; a combination of teratoma and embryonal carcinoma [training.seer.cancer.gov]

Trophoblastic Tumor (e.g. [fpnotebook.com]

Chorioamnionitis

DC-SIGN-positive cells were increased in the chorioamniotic mesodermal layer of CCA cases. [ncbi.nlm.nih.gov]

[…] disease/Gebelikte trofoblastik hastalık249Giant cell tumor/Dev hücreli tümör76Gonadotropin/Gonadotropin143Gynecologic oncology/Jinekolojik onkoloji255Gynecologic tumor/Jinekolojik [tjoddergisi.org]

Macrophages in the chorionic trophoblastic layer of CCA cases were characterized by CD68 positivity. [ncbi.nlm.nih.gov]

Therapeutic Abortion

Of 180 women who underwent therapeutic abortion in a certain period in 1977, 71.7% were unmarried and 63.9% were unmarried primigravidas. At the first follow-up visit 3 to 6 weeks postabortion 55.0% of the unmarried primigravidas chose oral contraceptives and 43.2% chose intrauterine devices (IUDs). Of the unmarried[…] [ncbi.nlm.nih.gov]

Testicular Choriocarcinoma

Choriocarcinoma is a malignant growth of trophoblastic cells characterized by secretion of human chorionic gonadotropin. [ncbi.nlm.nih.gov]

Choriocarcinoma, a malignancy of trophoblastic cells, is characterized by the secretion of human chorionic gonadotropin (hCG). [ncbi.nlm.nih.gov]

cells Syncytio-trophoblastic cells Abundant syncytio-trophoblasts Syncytio-trophoblasts hCG+ Molecular / cytogenetics description Board review question #1 Which biomarker [pathologyoutlines.com]

Gestational Trophoblastic Neoplasm

Gestational trophoblastic disease (GTD) is an umbrella term for a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception. [cancercenter.com]

A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells. [icd9data.com]

Both types of IT cells develop from a population of trophoblastic cells in the trophoblastic columns that we have tentatively termed "villous IT cells." [pathology.jhu.edu]

Placental Disorder

Considering the key function of activin A on trophoblast cell behaviors and placenta development, we proposed miR-195 may affect trophoblast cell invasion by repressing the [journals.lww.com]

PHDs were mainly expressed in syncytiotrophoblast leaf cells and trophoblast cells with PHD-1 mRNA specifically highly expressing in extravillous trophoblast cells (Figure [ijbs.com]

The decidua, the most superficial layer from the maternal side (top), comprises maternal uterine and immune cells, as well as specialized glycogen-storing cells from the trophoblast [nature.com]

Malignant Placental Neoplasm

cells. [codes.iarc.fr]

Choriocarcinoma is a highly malignant neoplasm resulting from the malignant transformation of proliferating trophoblastic cells and the molecular mechanisms leading to this [ncbi.nlm.nih.gov]

Both neoplasms were characterized by a predominance of uniform but highly atypical mononucleate trophoblastic cells. [ncbi.nlm.nih.gov]

Placental Cyst

Subsequent histological and biochemical examinations seem to prove their origin from the trophoblastic «X-cells» and confirm their frequent benign nature. [moh-it.pure.elsevier.com]

cells Back to top [pathologyoutlines.com]

Ashley Moffett and colleagues describe the generation of long-term, genetically stable organoid cultures of specialist trophoblast cells derived from first trimester human [natureasia.com]

Complete Hydatidiform Mole

These results suggest that these cells exhibit characteristics of trophoblastic cells, especially cytotrophoblastic cells. [ncbi.nlm.nih.gov]

A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells. [icd9data.com]

Microscopic examination demonstrated hydropic degeneration of all the chorionic villi with trophoblastic cell proliferation consistent with a complete hydatidiform mole. [ncbi.nlm.nih.gov]

Gestational Trophoblastic Disease

Ultrasound may be helpful in differentiating epithelioid trophoblastic tumor from placental-site trophoblastic tumor, another tumor of intermediate trophoblastic cells, which [ncbi.nlm.nih.gov]

The trophoblastic cells were generally bland. However, a subset of trophoblastic cells showed large, hyperchromatic nuclei in some areas. [ncbi.nlm.nih.gov]

During fertilization, trophoblastic cells invade the endometrium, blood vessels and myometrium to establish fetomaternal circulation. [oncolex.org]

Placental-Site Trophoblastic Tumor

Samples collected from uterus at the autopsy revealed large trophoblastic cells with eosinophilic cytoplasm. [ncbi.nlm.nih.gov]

IST-2 cells were highly motile and invasive in culture as compared to choriocarcinoma JEG-3 cells and normal extravillous trophoblastic cells. [ncbi.nlm.nih.gov]

PSTT develops from neoplastic transformation of presumable trophoblastic stem cell and assumes a differentiation toward a specific type of trophoblastic cells, called intermediate [link.springer.com]

Epithelioid Trophoblastic Tumor

Immunostaining showed that these tumor cells had a lower Ki67 index than choriocarcinoma, and epithelioid trophoblastic cell tumor although they exhibited an epithelioid trophoblastic [ncbi.nlm.nih.gov]

ETT originates from the intermediate trophoblastic cells of chorion laeve. [ncbi.nlm.nih.gov]

Trophoblastic Neoplasm

OBJECTIVE: To evaluate the role of p27Kip1 in tumorigenesis and the development of trophoblastic cell disease. [ncbi.nlm.nih.gov]

The cells resemble the trophoblastic cells in the chorion laeve, and we have therefore designated them "chorionic-type intermediate trophoblast." [ncbi.nlm.nih.gov]

Placenta Succenturiata

These two functions are fulfilled by different specialized trophoblast cell subtypes, and my laboratory has been studying how their formation and functions are regulated during [ncbi.nlm.nih.gov]

syncytiotrophoblast cells, extravillous trophoblast cells, decidual cells and blood vessels. [web.archive.org]

[…] by the trophoblastic cells. [intechopen.com]

Adhesion of Amnion to Fetus

Instead, the blood comes into direct contact with the embryonic trophoblast cells. [study.com]

[…] mononuclear cells) ⑦ Trophoblast cells further differentiate into villous and extravillous trophoblast Villous trophoblast cells give rise to chorionic villi and are responsible [pathophys.org]

Trophoblast cells are an exception, producing instead their own unique histocompatibility antigen. [education.med.nyu.edu]

Leaking Abdominal Aortic Aneurysm

[…] and trophoblast cells. [scholar.google.com.cu]

Todeschini, E Fulcheri, PL Venturini Gynecologic oncology 84 (2), 280-284, 2002 100 2002 Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells [scholar.google.com.cu]

Preeclampsia

The MHC status of trophoblast cells is a crucial factor to be considered, as these molecules can act as ligands for uterine immune cells, including T cells, NK cells and myelomonocytic [ncbi.nlm.nih.gov]

These findings obtained suggest that preeclampsia develops upon increased macrophage activity, leading to destruction of the placenta trophoblast cells. [ncbi.nlm.nih.gov]

Herein we summarize the current findings regarding the expression of placental miRNAs and their function, especially in the trophoblast cells. [ncbi.nlm.nih.gov]

Placentitis

Extravillous trophoblast cells migrate into the decidua and remodel uterine arteries. [ncbi.nlm.nih.gov]

To investigate the expression of ICAM-1 by villous trophoblasts, its relationship with rupture of the trophoblastic barrier and influx of immune cells into the villi, we analysed [ncbi.nlm.nih.gov]

Cytomegalovirus infection of trophoblast cells elicits an inflammatory response: a possible mechanism of placental dysfunction. Am J Obstet Gynecol 2006;194:535-41. [medigraphic.com]

Placental Infarction

Total numbers of cells were also seen to be markedly decreased, placental membrane showed 51% decrease in trophoblastic mass or cellular content. [oapublishinglondon.com]

The positive cytoplasmic immunohistochemical staining for human placental lactogen identified these cells as trophoblasts and the whole necrotic tissue fragment as a placental [circ.ahajournals.org]

transforms to the trophoblastic cell mass that intermixes with endometrial cells (10th postovulatory day). [radiologykey.com]

Trichothiodystrophy Type C

Antenatal diagnosis Prenatal diagnosis, based on measurement of DNA repair in trophoblasts or amniotic cells, is available. [orpha.net]

Hydatidiform Mole 2

cells. [icd10data.com]

After fertilisation, some cells from the fertilised ovum (called the trophoblast cells) develop into the placenta and membranes that form around the developing baby. [patient.info]

A slow-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a [icd10data.com]

SALL4-Related Disorders

In a trophoblastic component of a testicular germ cell tumor, small trophoblasts are positive but the larger cells including syncytiotrophoblasts are negative. D. [pubmed.ncbi.nlm.nih.gov]

SALL4 was consistently expressed in all germ cell tumors except some trophoblastic tumors and mature components of teratomas, in which it was selectively expressed in intestinal-like [pubmed.ncbi.nlm.nih.gov]

In adult tissues, it was only detected in germ cells. [pubmed.ncbi.nlm.nih.gov]

DNMT1-Related Disorder

Therefore, changes in DNAm measured in com-and term (n = 19) human placental samples of four cell populations: trophoblasts, Hofbauer cells, endothelial cells,and stromal [open.library.ubc.ca]

Single-cell RNA-seqreveals the diversity of trophoblast subtypes and patterns of differentiationin the human placenta. Cell Res. 2018:819–32.34. [open.library.ubc.ca]

Here, we present the first methylome-wide analysis of first trimester (n = 9) and term (n = 19) human placental samples of four cell populations: trophoblasts, Hofbauer cells [open.library.ubc.ca]

Polyembryoma

Clinically, this patient showed pseudoprecocious puberty caused by elevated HCG which is synthesized by trophoblastic cells in polyembryoma. [ncbi.nlm.nih.gov]

Hepatoid cells may rarely be seen, and syncytio trophoblast giant cells are more frequent, sometimes causing endocrine manifestations. [humpath.com]

[…] most common cell and shows a water-clear cytoplasm; ‘intermediate trophoblast’ cells show more eosinophilic cytoplasm. [abdominalkey.com]

Mosaic Trisomy 21

In mitotic CPM the trisomic cell line arises from postzygotic mitotic duplication of one chromosome in the progenitors of a placental cell lineage (either trophoblast or extra [fn.bmj.com]

Additionally, both placental cell lineages, trophoblast as well as chorionic stroma, should be analysed before excluding a diagnosis of CPM. [fn.bmj.com]

(A) Mitotic CPM arises from a diploid zygote when a postzygotic error occurs in one of the placental cell lineages (trophoblast or mesenchymal stroma). [fn.bmj.com]

Pineal Teratoma

Pathology Findings Microscopic examination revealed that the resected tumor cells in all patients were dimorphic and were composed of mononucleated trophoblastic cells with [ajnr.org]

Nests of tumor cells are surrounded by a stroma of trophoblastic cells and small reactive lymphocytes. [ispn.guide]

Frequent hemorrhage is seen in PICCC due to the fragility of vessels perfusing these trophoblastic tumors and due to the innate capacity of trophoblastic cells to invade and [ajnr.org]

Hyperemesis

a condition that causes abnormal cell growth in the uterus. [insider.com]

Women with trophoblastic disease – an extremely rare condition that involves abnormal growth of cells inside the uterus – can also be more likely to get HG (Sheffield Department [nct.org.uk]

Other factors that can put a person at risk for developing hyperemesis gravidarum include being overweight, being prone to motion sickness, or having trophoblastic disease [insider.com]