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18 Possible Causes for Tryptophan Increased, Volatile Mood

  • Endogenous Depression

    increases the production of serotonin, three doses per week of this simple low-cost solution effectively protect me from serotonin deficient depression.[balancingbrainchemistry.co.uk] Antidepressants however not the only way to raise serotonin there is evidence that raising the level of tryptophan (the amino acid that serotonin is made from) in the brain[balancingbrainchemistry.co.uk]

  • Reactive Depression

    increases the production of serotonin, three doses per week of this simple low-cost solution effectively protect me from serotonin deficient depression.[balancingbrainchemistry.co.uk] Antidepressants however not the only way to raise serotonin there is evidence that raising the level of tryptophan (the amino acid that serotonin is made from) in the brain[balancingbrainchemistry.co.uk]

  • Chronic Fatigue Syndrome

    Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome. British Journal of Health Psychology 15(4):779-796.[nap.edu] IL-1β also increases brain tryptophan concentrations and the rate of 5- hydroxytryptamine (5-HT) metabolism, which may further activate the HPA axis [ 154 ].[doi.org] Other studies have failed to find attentional bias but have found greater mood volatility with rumination (Martin and Alexeeva, 2010), suggesting variability in the ability[nap.edu]

  • Obstructive Sleep Apnea

    This includes the use of fluoxetine, paroxetine, acetazolamide and tryptophan among others.[en.wikipedia.org] Stroke and other cardiovascular disease are related to OSA and those under the age of 70 have an increased risk of early death.[en.wikipedia.org]

  • Migraine

    Tryptophan depletion increases nausea, headache and photophobia in migraine sufferers. Cephalalgia 2006 ; 26: 1225 – 33. Google Scholar SAGE Journals ISI 30.[doi.org] Effect of tryptophan depletion on symptoms of motion sickness in migraineurs. Neurology 2005 ; 65: 620 – 2. Google Scholar Crossref Medline ISI 29. Drummond, PD.[doi.org]

  • Dementia

    In Alzheimer's dementia, there are reduced levels of serotonin and its precursors such as tryptophan [ 5 ].[doi.org] In theory, SSRIs could increase these, promote neurogenesis [ 6 ], encourage migration of new neurones to damaged brain areas [ 7 ] and decrease inflammation [ 8 ].[doi.org] SSRIs are highly selective for the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) receptor and act by increasing the extracellular levels of serotonin through reuptake[doi.org]

  • Drug Dependence

    There is evidence that bingeing on sugar-dense, palatable foods increases extracellular dopamine in the striatum and thereby possesses addictive potential.[ncbi.nlm.nih.gov] Moreover, elevated blood glucose levels catalyze the absorption of tryptophan through the large neutral amino acid (LNAA) complex and its subsequent conversion into the mood-elevating[ncbi.nlm.nih.gov]

  • Addictive Behavior

    There was an increase in tryptophan catabolites--quinolinic acid, serotonin, nicotine, and strychnine--in patients with addiction, and a reduction in tyrosine catabolites-[ncbi.nlm.nih.gov] , thinking and perception perceptual distortion or bizarre thought that recurs after the chemical effects of a drug have worn off 1. volatile solvents (paint thinners, gasoline[quizlet.com] The isoprenoid pathway was upregulated with increased digoxin synthesis in addiction.[ncbi.nlm.nih.gov]

  • Mania

    Furthermore, unaffected relatives tended to show increased impulsivity in the ATD condition.[ncbi.nlm.nih.gov] In a double-blind, crossover design, 20 unaffected relatives from multiple bipolar families and 19 control subjects underwent acute tryptophan depletion (ATD) ( 25 ).[ncbi.nlm.nih.gov]

  • Premenstrual Syndrome

    You can try: Avoiding caffeine, alcohol, and carbonated drinks Reducing your sugar intake Avoiding smoked cheeses, meats, and fish (as they can increase your fluid retention[articles.mercola.com] This may be because carbohydrates provide tryptophan, the precursor to serotonin.6 A craving for or an increase in carbohydrate intake is likely a manifestation of the body's[todaysdietitian.com] Increasing complex carbohydrate intake premenstrually has been shown to improve mood, carbohydrate craving and memory in PMS, by potentially i ncreasing tryptophan, a precursor[doi.org]

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