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1 Possible Causes for UDP-GlcNAc Decreased

  • PGM3-Related Congenital Disorder of Glycosylation

    Impaired function of PGM3 is demonstrated by decreased enzyme activity, reduced UDP-GlcNAc and reduced N-linked glycosylation and O-linked glycosylation [4] PGM3 is composed[en.wikipedia.org] -1-P), a precursor step for the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc).[en.wikipedia.org] […] the crucial catalyst for the glycosylation pathway [6] [7] Protein PGM3 is required for the reversible conversion of GlcNAc-6-phosphate (GlnNAc-6-P) to GlnNAc-a-phosphate (GlcNac[en.wikipedia.org]

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