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138 Possible Causes for Unconjugated Bilirubin Increased

  • Thalassemia

    Treatments for thalassemias depend on the type and severity of the disorder. People who are carriers or who have alpha or beta thalassemia trait have mild or no symptoms. They’ll likely need little or no treatment. Doctors use three standard treatments for moderate and severe forms of thalassemia. These[…][web.archive.org]

  • Biliary Atresia

    To establish the risks of developing of hepatic tumours and to investigate their clinical and imaging findings in children with biliary atresia (BA) after Kasai portoenterostomy (Kasai). Among 157 children who had undergone Kasai for BA over an 18 year period, patients who had newly developed hepatic tumours were[…][ncbi.nlm.nih.gov]

  • Pyruvate Kinase Deficiency

    Embden-Meyerhof pathway Erythrocytes (mature red blood cells) completely depend on glucose as a source of energy. Glucose is usually catabolized to pyruvate and lactate in the Embden-Meyerhof pathway, which is the major anaerobic glycolytic pathway. In the process, adenosine triphosphate (ATP), which is essential[…][emedicine.medscape.com]

  • Vitamin B12 Deficiency

    Biochemistry There may be an increase in plasma unconjugated bilirubin due to increased destruction of red cell precursors in the marrow.[patient.info]

  • Crigler-Najjar Syndrome

    The serum unconjugated bilirubin increased in the proband from 156.4 micromol/L to 243.5 micromol/L after he started a low calorie intake, and it decreased to 51.8 micromol[ncbi.nlm.nih.gov] […] concentration None Reduction Bile Usually pale: contains small amounts of unconjugated bilirubin Increased proportion of bilirubin monoglucoronide Prognosis Kernicterus Usually[criglernajjar.altervista.org] Crigler Najjar (CN) disease is a genetic disorder which results in increased unconjugated bilirubin level.[ncbi.nlm.nih.gov]

  • Cholelithiasis

    ., sickle cell disease, hereditary spherocytosis ) Cirrhosis Pathophysiology : hemolysis increase in circulating unconjugated bilirubin increased uptake and conjugation of[amboss.com] unconjugated bilirubin (from hemolytic syndromes, ileal dysfunction / bypass, bacterial contamination of biliary tree) Clofibrate: Anticholesterol drug that increases HMG[pathologyoutlines.com] […] and lecithin in the bile increased unconjugated bilirubin and fatty acids precipitation of calcium carbonate, cholesterol, and calcium bilirubinate in bile Clinical features[amboss.com]

  • Obstructive Jaundice

    But as the body creates more and more it will surpass the livers ability to process the bilirubin and the levels of unconjugated bilirubin will increase.[examrefresh.com] Decreased excretion into bile Cholestatic jaundice Obstructive jaundice Unconjugated hyperbilirubinemia 80-85 % of unconjugated bilirubin (indirect) in unconjugated hyperbilirubinemia[meddean.luc.edu] Checking LFTs If normal, ask for: Levels of conjugated/unconjugated bilirubin (direct/indirect bilirubin).[patient.info]

  • Liver Cirrhosis

    Unconjugated bilirubin is conjugated with glucuronic acid in hepatocytes to increase its water solubility and is then rapidly transported into bile.[aafp.org] The finding of bilirubin in urine is a particularly sensitive indicator of the presence of an increased serum conjugated bilirubin level.[aafp.org] Indicators of How Well the Liver Functions BILIRUBIN Bilirubin results from the enzymatic breakdown of heme.[aafp.org]

  • Gilbert's Disease

    Gilbert's syndrome is a phenotypic effect, characterized by mild jaundice due to increased unconjugated bilirubin, that arises from several different genotypic variants of[en.wikipedia.org] In patients with Gilbert syndrome, there occurs an increased level of unconjugated bilirubin in the blood.[symptoma.com] . ( 18343383 ) Schwertner H.A....VA-tek L. 2008 45 ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin[malacards.org]

  • Choledocholithiasis

    ., sickle cell disease, hereditary spherocytosis ) Cirrhosis Pathophysiology : hemolysis increase in circulating unconjugated bilirubin increased uptake and conjugation of[amboss.com] […] and lecithin in the bile increased unconjugated bilirubin and fatty acids precipitation of calcium carbonate, cholesterol, and calcium bilirubinate in bile Clinical features[amboss.com] Risk factors : bacterial infection in the biliary tract (e.g., Clonorchis sinensis, Opisthorcus species) Pathophysiology : bacterial β-glucuronidase hydrolyzes conjugated bilirubin[amboss.com]

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