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21 Possible Causes for Unresponsive to ACTH Stimulation

  • Adrenal Insufficiency

    , or they may have atrophic adrenals that are unresponsive to ACTH.[merck.com] Patients receiving corticosteroids for 4 wk may have insufficient ACTH secretion during metabolic stress to stimulate the adrenals to produce adequate quantities of corticosteroids[merck.com]

  • Suprasellar Tumor

    LH, FSH, ACTH, and GH exhibited unresponsiveness to the stimulation.[kjim.org] In hormonal studies with a combined stimulation test, performed immediately after admission, only TSH showed a prompt response.[kjim.org]

  • Addison's Disease

    […] to ATCH stimulation.[pedclerk.bsd.uchicago.edu] ACTH receptor gene mutation results in Familial Glucocorticoid Deficiency an autosomal recessive disorder in which cortisol and androgen secretion are deficient and unresponsive[pedclerk.bsd.uchicago.edu]

  • Congenital Isolated ACTH Deficiency

    unresponsiveness.[hon.ch] VIP has been shown to stimulate adrenocortical steroidogenesis directly [ 32 ] and nerve fibers immunoreactive for VIP are found in the lacrimal glands [ 33 ] and esophagus[hon.ch] Allgrove syndrome may reflect a primary autonomic neuropathic process which causes alacrima and esophageal dysmotility, and also, in some way, leads to an acquired form of ACTH[hon.ch]

  • Triple A Syndrome

    unresponsiveness.[hon.ch] VIP has been shown to stimulate adrenocortical steroidogenesis directly [ 32 ] and nerve fibers immunoreactive for VIP are found in the lacrimal glands [ 33 ] and esophagus[hon.ch] Allgrove syndrome may reflect a primary autonomic neuropathic process which causes alacrima and esophageal dysmotility, and also, in some way, leads to an acquired form of ACTH[hon.ch]

  • Ectopic ACTH Syndrome

    ) dexamethasone suppression test in 15 (94%) and unresponsiveness to CRH stimulation in 12 (75%).[ncbi.nlm.nih.gov] No ACTH gradient during inferior petrosal sampling was noted in 13 of 15 (87%).[ncbi.nlm.nih.gov] Dynamic endocrine tests revealed markedly elevated plasma ACTH levels (211 116pg/mL) and cortisol levels (60.9 30.1µg/dL) which showed resistance to overnight high-dose (8mg[ncbi.nlm.nih.gov]

  • ROHHAD Syndrome

    . • Growth failure GH deficiency or unresponsiveness. • excessive secretion of ACTH, hypercortisolism • glucocorticoid deficiency. • hypogonadotropic hypogonadism. • Hyperprolactinemia[slideshare.net] […] insipidus. • hypogonadism • precocious puberty, • central hypothyroidism and Hyperthyrotropinemia. 12. manifestation % Rapid-onset obesity 100 % Failed growth hormone 60 % stimulation[slideshare.net]

  • Acquired Adrenogenital Syndrome

    Adrenal carcinomas are generally unresponsive to ACTH.[teleplexus.com] In about 50% of cases of adrenal adenoma, ACTH stimulation will produce a clear and sometimes marked increase in plasma and urinary cortisol.[teleplexus.com] […] fivefold increase in urinary cortisol in patients with Cushing's disease, in whom the adrenals show bilateral hyperplasia and hyperresponsiveness due to chronic endogenous ACTH[teleplexus.com]

  • Bilateral Adrenalectomy

    These distinctly increased steroid metabolites were suppressed by dexamethasone but unresponsive to human chorionic gonadotropin stimulation, supporting the role of ACTH,[ncbi.nlm.nih.gov]

  • Isolated Congenital Alacrima

    Familial glucocorticoid deficiency (FGD), or hereditary unresponsiveness to ACTH (online Mendelian inheritance in man no. 202200), is an autosomal recessive disorder resulting[academic.oup.com] unresponsiveness.[hon.ch] […] from resistance to the action of ACTH to stimulate glucocorticoid production in the adrenal cortex.[academic.oup.com]

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