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313 Possible Causes for Upper Limb Weakness and Atrophy

  • Distal Hereditary Motor Neuropathy Type 5

    Type V (sometimes notated as Type 5) is a disorder characterized by autosomal dominance , weakness of the upper limbs that is progressive and symmetrical, and atrophy of the[en.wikipedia.org] Muscle atrophy and weakness in upper limbs, mainly in the hands, occurred later. Disease progression was very slow and variable.[jmg.bmj.com] Muscle weakness and atrophy began and predominated in the distal portions of legs, and were noted to a less extent in distal upper limbs.[nature.com]

  • Monomelic Amyotrophy

    The main clinical findings seen in patients with MA include weakness and atrophy restricted to a single upper or lower limb.[scielo.br] limb weakness (with muscular atrophy)-two of them with distal and one with proximal localization.[biomedsearch.com] Villa Asian Spine Journal. 2015; 9(5): 794 5 Dynamic MRI testing of the cervical spine has prognostic significance in patients with progressive upper-limb distal weakness[doi.org]

  • Peripheral Neuropathy

    […] and atrophy in the upper limbs.[ncbi.nlm.nih.gov] […] syndrome or brachial plexus neuritis) is a distinct peripheral nervous system disorder characterised by episodes (attacks) of extreme neuropathic pain and rapid multifocal weakness[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy Type 2G

    […] muscular dystrophy characterized by a variable onset (ranging from infancy to adolescence) of progressive proximal upper and lower limb muscle weakness and atrophy.[malacards.org] ) of progressive proximal upper and lower limb muscle weakness and atrophy.[rarediseases.info.nih.gov] There was a history of difficulty with standing from a sitting position, climbing stairs and raising his upper limbs above his head.[chs-journal.com]

  • Demyelinating Disease

    This weakness develops gradually, over weeks or months, without symptoms of acute muscle injury. Muscle atrophy, or decreased bulk, may be striking.[the-medical-dictionary.com] Symptoms include painless weakness of the limb muscles closest to the trunk and the girdle muscles, including the thighs, hips, shoulders, and upper arms.[the-medical-dictionary.com]

  • X-linked Parkinsonism-Spasticity Syndrome

    There are occasional reports of mild distal muscle atrophy but more marked involvement of the upper limbs with spasticity, weakness, or amyotrophy is not usually seen in pure[jnnp.bmj.com] A combination of upper and lower motor neuron signs is associated with these diseases, but muscle weakness and atrophy of two or more limbs is the primary feature.[britannica.com] A trace of terminal dysmetria may also be found in the upper limbs, but more florid cerebellar signs are not seen.[jnnp.bmj.com]

  • Radiculomyelopathy

    […] of a distal limb, with a predilection for the upper extremities.[consultant360.com] Symptoms Patients or their families often notice problems occurring in one or more of the patterns below: Limb weakness - usually affects the upper limbs: Causes patients[patient.info] Atrophy may occur if there is axonal degeneration secondary to chronic demyelination.[consultant360.com]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Atrophy and weakness: - distal upper limb - distal lower limb 100% 100% Babinski's sign 62% Male, female distribution ratio 1:1 Biochemical study: Low plasma citrate and[rarediseasesindia.org] Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.[uniprot.org] Proximal muscle weakness and early involvements of foot and hand Muscle weakness Upper limb, proximal No Yes Upper limb, distal Yes Yes Lower limb, proximal Yes Yes Lower[ojrd.biomedcentral.com]

  • Duchenne Muscular Dystrophy

    There is symmetrical and proximal muscle weakness, with the lower limbs being more severely affected than the upper limbs.[orpha.net] Clinical examination reveals muscle pseudohypertrophy affecting the calf muscles and there may be atrophy of more proximal muscles such as the quadriceps.[orpha.net]

  • Dilated Cardiomyopathy

    We hereby present a male patient with a diagnosis of symptomatic dilated cardiomyopathy at 44 years-old who developed, soon after, weakness of distal right upper limb.[ncbi.nlm.nih.gov] , myotatic areflexia in the upper limbs and hyporeflexia in the lower limbs.[ncbi.nlm.nih.gov] At the age of 58, neurological examination revealed severe atrophy of right thenar muscles, flexion contractures on the right elbow, wrist and fingers, bilateral calf hypertrophy[ncbi.nlm.nih.gov]

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