Upper Motor Neuron Degeneration: Causes & Reasons

Possible Causes for Upper Motor Neuron Degeneration

[…] magnetic stimulation a difficult technique with which to document serial upper motor neuron degeneration. [academic.oup.com]

Upper motor neuron degeneration generally causes spasticity (tightness in a muscle), slowness of movement, poor balance and incoordination, while lower motor neuron degeneration [mda.org]

[…] or neuropathologic examination signs of upper motor neuron (UMN) degeneration by clinical examination progressive spread of signs within a region or to other regions together [radiopaedia.org]

Amyotrophic Lateral Sclerosis Type 1

Pathologic features lower motor neuron signs loss of motor neurons within the anterior horns of the spinal cord and motor cranial nerve nuclei upper motor neuron signs degeneration [orthobullets.com]

neuron (LMN) degeneration by clinical, electrophysiological or neuropathologic examination, evidence of upper motor neuron (UMN) degeneration by clinical examination, and [physio-pedia.com]

Infantile-Onset Ascending Hereditary Spastic Paralysis

[…] the upper motor neurons. [ncbi.nlm.nih.gov]

[…] of the upper motor neurons whereas infantile-onset spastic paralysis is more severe and involves degeneration of upper and lower motor neurons Symptoms - Hereditary spastic [checkorphan.org]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Primary Lateral Sclerosis

Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS. [ncbi.nlm.nih.gov]

Primary lateral sclerosis begins when the nerve cells in the upper motor neurons degenerate. [healthguidance.org]

Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells. [ncbi.nlm.nih.gov]

Juvenile Primary Lateral Sclerosis

Primary lateral sclerosis begins when the nerve cells in the upper motor neurons degenerate. [healthguidance.org]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Lower Motor Neuron Syndrome with Late-Adult Onset

Pseudobulbar Palsy shares many of the symptoms of progressive bulbar palsy and is characterized by upper motor neuron degeneration and progressive loss of the ability to speak [advancedpsy.com]

[…] of the upper motor neurons [1]. [physio-pedia.com]

Amyotrophic Lateral Sclerosis Type 4

[…] or neuropathologic examination signs of upper motor neurone (UMN) degeneration by clinical examination progressive spread of signs within a region or to other regions together [radiopaedia.org]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Those criteria are as follows: Clinical evidence of upper motor neuron degeneration Clinical, electrophysiological, or neuropathological evidence of lower motor neuron degeneration [symptoma.com]

Amyotrophic Lateral Sclerosis Type 6

In the sixth edition of his book Brain, published in 1962, he made it clear that the three syndromes: upper motor neuron degeneration, lower motor neuron degeneration, and [dana.org]

[…] mixed upper motor and lower motor neuron degeneration should be regarded as manifestations of the same underlying disorder.3 ALS has been artificially distinct from other [dana.org]

Amyotrophic Lateral Sclerosis Type 7

motor neurons (Betz cells in the cortex) and anterior horn cells with secondary Wallerian degeneration 2. [radiopaedia.org]

Amyotrophic Lateral Sclerosis Type 5

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Amyotrophic Lateral Sclerosis Type 3

motor neurons (Betz cells in the cortex) and anterior horn cells with secondary Wallerian degeneration 2. [radiopaedia.org]

Amyotrophic Lateral Sclerosis Type 11

[…] in degenerating lower motor neurons. [orpha.net]

The pathological hallmarks comprise loss of motor neurons with intraneuronal ubiquitin-immunoreactive inclusions in upper motor neurons and TDP-43 immunoreactive inclusions [orpha.net]

Amyotrophic Lateral Sclerosis Type 10

Physical findings: In ALS, both the upper motor neurons and the lower motor neurons degenerate or die, ceasing to send messages to muscles. [secure.ssa.gov]

Amyotrophic Lateral Sclerosis

upper motor neuron degeneration was detected at autopsy. [ncbi.nlm.nih.gov]

The standard criteria for establishing the diagnosis of ALS are: the presence of lower and upper motor neuron degeneration with documented progression of symptoms, either [chealth.canoe.com]

Here, we present an atypical case of sporadic ALS that progressed very slowly, persisted for 19 years, and clinically appeared to only affect the lower motor neurons; however [ncbi.nlm.nih.gov]

Amyotrophic Lateral Sclerosis Type 9

[…] in degenerating lower motor neurons. [orpha.net]

The pathological hallmarks comprise loss of motor neurons with intraneuronal ubiquitin-immunoreactive inclusions in upper motor neurons and TDP-43 immunoreactive inclusions [orpha.net]

Distal Spinal Muscular Atrophy Type 4

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

motor neuron controlling muscle movement gradually degenerate, muscles becoming gradually weaker and begin to waste away In 75-80% of patients symptoms are first observed [thehumanthebody.com]

In PLS and PMA, the motor neuron degeneration is limited to the upper motor neuron and lower motor neuron, respectively. [mayomedicallaboratories.com]

Spastic Paraparesis-Deafness Syndrome

When the upper motor neurons degenerate, the circuit between the brain and the muscles is broken, and control of voluntary movements is lost. [medschool.lsuhsc.edu]

HSP is caused by degeneration of the upper motor neurons in the brain and spinal cord. Upper motor neurons control voluntary movement. [host.web-print-design.com]

HSP is caused by degeneration of the upper motor neurons in the brain and spinal cord. [biomediclabs.com]

Hereditary Spastic Paraplegia

Hereditary spastic paraplegia (HSP) describes a heterogeneous group of inherited neurodegenerative disorders in which the cardinal pathological feature is upper motor neurone [ncbi.nlm.nih.gov]

When the upper motor neurons degenerate, the circuit between the brain and the muscles is broken, and control of voluntary movements is lost. [medschool.lsuhsc.edu]

In hereditary spastic paraplegia, upper motor neurons slowly degenerate so the muscles do not receive the correct messages, causing progressive spasticity (increased muscle [rarediseases.info.nih.gov]

Amyotrophic Lateral Sclerosis Type 8

Some patients with ALS may initially present only with findings due to degeneration of the upper motor neurons. [rarediseases.org]

Diagnosis Amyotrophic lateral sclerosis is characterized by degeneration of both the upper and lower motor neurons. [rarediseases.org]

Progressive Bulbar Paralysis

In this type of MND, only the upper motor neurones degenerate. [leedsth.nhs.uk]

Motor neuron diseases (MNDs) are a group of neurological disorders characterized by progressive degeneration of upper motor neurons originating in the motor and premotor cortex [nrronline.org]

Spastic Paraplegia

The present case suggests that Klinefelter syndrome can present with both upper and lower motor neuron degeneration. [ncbi.nlm.nih.gov]

When the upper motor neurons degenerate, the circuit between the brain and the muscles is broken, and control of voluntary movements is lost. [medschool.lsuhsc.edu]

Autosomal Dominant Spastic Paraplegia Type 6

When the upper motor neurons degenerate, the circuit between the brain and the muscles is broken, and control of voluntary movements is lost. [medschool.lsuhsc.edu]

HSP is caused by degeneration of the upper motor neurons in the brain and spinal cord. Upper motor neurons control voluntary movement. [sp-foundationorg.presencehost.net]

The reason why upper motor neurons degenerate in HSPs is because one or more proteins essential for proper function or maintenance of these cells is missing or improperly [medschool.lsuhsc.edu]

Autosomal Dominant Spastic Paraplegia Type 13

When the upper motor neurons degenerate, the circuit between the brain and the muscles is broken, and control of voluntary movements is lost. [medschool.lsuhsc.edu]

HSP is caused by degeneration of the upper motor neurons in the brain and spinal cord. Upper motor neurons control voluntary movement. [sp-foundationorg.presencehost.net]

[…] to degeneration of the upper motor neurons, causing weakness and lower limb spasticity, along with peripheral neuropathy [ 11, 12 ]. [avensonline.org]

Adult Primary Lateral Sclerosis

upper motor neuron degeneration with relatively little muscle wasting but prominent stiffness. [ouh.nhs.uk]

neuron degeneration Primary Lateral Sclerosis pure upper motor neuron degeneration Adult-Onset Spinal Muscular Atrophy includes a broad range of primary motor neuron disease [quizlet.com]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Motor Neuron Disease

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Slowly upper and lower motor neuron degeneration, even with non-motor clinical features, should prompt a sequencing of SOD1. [ncbi.nlm.nih.gov]

The patients also showed clinical and electrophysiological signs of upper and/or lower motor neuron degeneration. [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Ataxia Type 2

neurone degeneration leading to progressive spasticity and weakness of the lower limbs. [discovery.ucl.ac.uk]

Abstract Hereditary spastic paraplegia (HSP) describes a heterogeneous group of inherited neurodegenerative disorders in which the cardinal pathological feature is upper motor [discovery.ucl.ac.uk]

Autosomal Dominant Spastic Paraplegia Type 4

When the upper motor neurons degenerate, the circuit between the brain and the muscles is broken, and control of voluntary movements is lost. [medschool.lsuhsc.edu]

HSP is caused by degeneration of the upper motor neurons in the brain and spinal cord. Upper motor neurons control voluntary movement. [sp-foundationorg.presencehost.net]

Mutations in both the spastin and paraplegin genes have been associated with upper motor neurone degeneration in hereditary spastic paraparesis [3]. [wikigenes.org]

Amyotrophic Lateral Sclerosis Type 17

[…] of the corticospinal tracts, neurons in the motor cortex and brainstem, and anterior horn cells in the spinal cord Primary lateral sclerosis Degeneration of upper motor neurons [fadavispt.mhmedical.com]

& lower motor neuron degeneration in cranial, cervical, thoracic & lumbosacral regions the most striking changes are seen in affected muscles & anterior spinal nerve roots [anvita.info]

Progressive Muscular Atrophy

[…] in ALS it was the upper motor neurone degeneration that was primary, with lower motor neurone degeneration being secondary. [en.wikipedia.org]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology 2007;68:1571-5. Ravits JM, La Spada AR. [acnr.co.uk]

Amyotrophic Lateral Sclerosis Type 21

Types of participants All those with a clinical diagnosis of ALS/MND (pure mixed upper motor neuron and lower motor neuron degeneration with supportive electromyogram) according [cochranelibrary.com]