Uric Acid Increased: Causes & Reasons

Possible Causes for Uric Acid Increased

(xanthine oxidase inhibitors like allopurinol to decrease production of uric acid, uricosuric drugs to increase excretion of uric acid) Emerging Therapeutics Most mammals [lifeextension.com]

Risk factors There are a number of factors that can increase the likelihood of hyperuricemia, and therefore gout: Age and gender: Men produce more uric acid than women, though [medicalnewstoday.com]

This may happen because either uric acid production increases or, more often, the kidneys cannot remove uric acid from the body well enough. [rheumatology.org]

Gouty Arthritis

On follow-up, it was confirmed that as serum C3 level returned to normal, urinary excretion of uric acid increased and serum uric acid level decreased, thereby resolving the [ncbi.nlm.nih.gov]

[…] excretion of uric acid chronic managment of hyperuricemia in pt with history of gout [quizlet.com]

The uric acid level in the plasma and other extracellular fluids increases in case of a positive uric acid balance. [lecturio.com]

Tumor Lysis Syndrome

Fluid hydration Increased uric acid excretion i) Allopurinol ii) Hemodialysis Increased uric acid breakdown i) Rasburicase Clinical dehydration Resuscitate with isotonic [learn.pediatrics.ubc.ca]

Catabolism of the nucleic acids to uric acid leads to hyperuricemia, and the marked increase in uric acid excretion can result in the precipitation of uric acid in the renal [uptodate.com]

PATHOGENESIS High levels of both uric acid and phosphate increase the severity of acute kidney injury because uric acid precipitates readily in the presence of calcium phosphate [slideshare.net]

Urate Kidney Stone

This increases the level of uric acid in the body which may increase the risk of urice acid stone formation. Read more on high uric acid levels. [healthhype.com]

Causes of High Uric Acide Levels: Primary hyperuricemia Increased production of uric acid from purine Your kidneys cannot get rid of the uric acid in your blood, resulting [chemocare.com]

If too much uric acid is produced or not enough is removed, it can accumulate in the body, causing increased levels in the blood (hyperuricemia). [labtestsonline.org]

Acute Polyarticular Gout

Secondary cases of hyperuricaemia can be caused by Impaired excretion of uric acid: chronic renal failure, thiazide diuretics, hypertension; Increased production of uric acid [myvmc.com]

Flares may be precipitated by decreased uric acid excretion or increased production. [clinicaladvisor.com]

acid metabolism that increases production or interferes with excretion of uric acid. [medical-dictionary.thefreedictionary.com]

Chronic Gouty Nephropathy

acid -> increased uric acid retention and deposition complicatons urate stone formation may occur increased risk of pyelonephritis acute urate nephropathy presents as acute [zen104556.zen.co.uk]

Causes of hyperuricemia can be divided into two major categories: decreased clearance of uric acid from the kidney and increased synthesis of uric acid. [hopkinsarthritis.org]

Risk factors You're more likely to develop gout if you have high levels of uric acid in your body. Factors that increase the uric acid level in your body include: Diet. [mayoclinic.org]

Lesch-Nyhan Syndrome

Since uric acid is near its physiologic limit of solubility in the body, the persistent hyperuricemia increases the risk of uric acid crystal precipitation in the tissues [emedicine.medscape.com]

The increased production of uric acid leads to hyperuricemia. [namrata.co]

Increase in uric acid production can lead to hyperuricemia that increased uric acid crystallization that will result to inflammation and stone formation. [syndromespedia.com]

Cerebral Salt-Wasting Syndrome

Uric acid Fractional excretion of uric acid (FEUA) is increased in patients with the cerebral salt-wasting syndrome and hyperuricemia is detected. [symptoma.com]

In SIADH, sodium resorption in the proximal tubule may be decreased because of an expanded ECFV, which can lead to less uric acid absorption and increased uric acid loss in [thepermanentejournal.org]

uric acid clearance. [karger.com]

Acquired Fanconi Syndrome

[…] of potassium (FEK) and uric acid (FEUA), low-molecular-weight proteinuria, panaminoaciduria and glycosuria. [ncbi.nlm.nih.gov]

The tubular reabsorption of phosphate (%TRP) was decreased, although the fractional excretion of uric acid (FEUA) was increased, indicating disturbed proximal tubular reabsorption [bmcnephrol.biomedcentral.com]

Various defects of proximal tubular transport function occur, including impaired resorption of glucose, phosphate, amino acids, bicarbonate, uric acid, water, potassium, and [merckmanuals.com]

Chronic Lead Nephropathy

[…] lead burden; high serum uric acid, gout (~50%) Uric acid (gouty) nephropathy Long-standing inconsistently treated hyperuricemia Hypertension, proteinuria Hypercalcemic nephropathy [empendium.com]

Obermayr, RP, Temml, C, Gutjahr, G, Knechtelsdorfer, M, Oberbauer, R, Klauser-Braun, R. ” Elevated uric acid increases the risk for kidney disease”. [renalandurologynews.com]

Studies have suggested enhanced reabsorption and reduced secretion of uric acid, explaining the high prevalence of gout. [emedicine.medscape.com]

Chronic Kidney Insufficiency

The increased level of serum uric acid was closely related with creatinine clearance and urine volume. [dict.cnki.net]

Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R, Klauser-Braun R: Elevated uric acid increases the risk for kidney disease. [karger.com]

When treated with hemodialysis, The decrease of serum uric acid was 45.9%,... 69 patients with chronic renal insufficiency were examined, of which serum uric acid>6mg% ccured [dict.cnki.net]

Familial Juvenile Hyperuricemic Nephropathy Type 3

Take plenty of water to increase the excretion of uric acid. [drhiteshgopalan.com]

[…] and increased concentration of uric acid in the blood. [patientslikeme.com]

acid in the urine (hypouricuria) and increased concentrations of uric acid in the blood (hyperuricenmia). [healthmedicinet.com]

Essential Hypertension

Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001; 38 : 1101–1106. 19. [doi.org]

Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem 1991;266:8604-8. 61. [ijem.in]

For women, age, BMI, and the prevalence of hypercholesterolemia and hyperuricemia, as well as systolic and diastolic BP, were significantly greater in subjects with hypertension [doi.org]

Preeclampsia

Uric acid. Increased uric acid in the blood is often the earliest laboratory finding related to preeclampsia. [cigna.com]

Increased uric acid High hematocrit level Low platelet count Increase in partial thromboplastin time or PTT Amount of electrolytes Kidney function tests Liver function tests [emedicinehealth.com]

Polycythemia Vera

Increased uric acid Presence of the JAK2 mutation Hypercellular bone marrow 5. [slideshare.net]

Severe continuous small joint pain Patients will present with symptoms of gout as a result of increased uric acid production. Gout mainly affects big toe. [medicaljoyworks.com]

[…] turnover of red cells, leukocytes, and platelets with the attendant increase in uric acid and cytokine production. [theoncologyinstitute.com]

Obesity

Endocrine-disrupting chemicals in foods and increased uric acid levels from meat and sugar intake may increase obesity risk. [nutritionfacts.org]

Fructose is also the only sugar able to increase blood uric acid concentrations, and SSB consumption has been linked to development of hyperuricemia (serum uric acid level [doi.org]

It is likely that higher BMI increases the risk of gout by increasing the serum uric acid level. [dx.doi.org]

Hypertension

Increased dietary ingestion of purine‐containing foods or decreased uric acid excretion lead to high uric acid serum levels (hyperuricemia). [doi.org]

Piyanuch Thitiwuthikiat, Duangduan Siriwittayawan and Teonchit Nuamchit, Prehypertension and high serum uric acid increase risk of arterial stiffness, Scandinavian Journal [dx.doi.org]

Epidemiological and experimental studies suggest a linkage between hyperuricemia and hypertension. Hyperuricemia affects 25-40 % of patients with untreated hypertension. [ncbi.nlm.nih.gov]

Morbid Obesity

which increased blood uric acid levels Psychological sequelae or associated mental depression and emotional stress Signs and symptoms due to gallstones (cholelithiasis) [dovemed.com]

She presented high levels of blood urea, creatinine and aminotransferases, in addition to hyperkalemia and hyperuricemia. [ncbi.nlm.nih.gov]

Weight loss programs may sometime lead to complications like cardiac arrhythmia, electrolyte derangements, hyperuricemia, cholelithiasis, and psychological conditions like [symptoma.com]

Chronic Alcoholism

Gout Gout is a type of arthritis caused by the formation of uric acid crystals in the joints. It can be very painful. [onhealth.com]

Cardiovascular system: Holiday heart syndromes Dilatative cardiomyopathy caused by alcoholism Arterial hypertension Apoplexy Coronary heart disease Metabolism : Hypertriglyceridemia Hyperuricemia [flexikon.doccheck.com]

Alcohol intake may increase the risk of developing gout, particularly in men, and beer seems to cause the condition more than other types of alcohol. [onhealth.com]

Diabetes Mellitus

Fructose is also the only sugar able to increase blood uric acid concentrations, and SSB consumption has been linked to development of hyperuricemia (serum uric acid level [doi.org]

[…] whereas uric acid (HR per 1 mmol/L increase, 2.05) and physical inactivity during leisure time (HR, 1.80) were associated with diabetes development in women only. [doi.org]

However, the quantities of fructose contained in SSBs are far greater than those contained in these preloads. 70 Fructose can also increase blood uric acid concentrations. [doi.org]

Primary Myelofibrosis

All myeloproliferative neoplasms may lead to elevated uric acid levels and gout as a result of increased cellular breakdown. [amboss.com]

acid levels Increased susceptibility to infection, such as pneumonia Pallor and shortness of breath due to anemia In rarer cases, a raised red blood cell volume Cutaneous [en.wikipedia.org]

[…] lactate dehydrogenase Overt: increased lactate dehydrogenase Alkaline phosphatase, uric acid, leukocyte alkaline phosphatase and vitamin B12 are increased (Leuk Lymphoma [pathologyoutlines.com]

Psoriasis

In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism. [ncbi.nlm.nih.gov]

acid concentration may be increased Low levels of circulating immune complexes have been detected in 56% of patients Serum immunoglobulin A levels are increased in two thirds [emedicine.medscape.com]

Psoriatic patients had higher levels of serum uric acid (6.25 ± 1.62 vs 5.71 ± 1.35 mg/dl; P=0.019) and significantly greater prevalence of hyperuricemia (31.6% vs 16.2%; [ncbi.nlm.nih.gov]

Non-Hodgkin Lymphoma

An increased level of uric acid can lead to tumor lysis syndrome (TLS). [lls.org]

acid. [symptoma.com]

Tumor lysis syndrome is heralded by the development of hypocalcemia, hyperkalemia, hyperphosphatemia and hyperuricemia, as well as acute renal failure; consult nephrology [clinicaladvisor.com]

Myeloproliferative Disease

All myeloproliferative neoplasms may lead to elevated uric acid levels and gout as a result of increased cellular breakdown. [amboss.com]

Furthermore, ruxolitinib also decreased plasma levels of N-terminal pro-brain natriuretic peptide, von Willebrand antigen, ristocetin-cofactor activity and uric acid, and [err.ersjournals.com]

As we have explained, patients with myeloproliferative disease are at an increased risk of developing hyperuricemia and gouty arthritis; therefore, serum uric acid levels [lecturio.com]

Chronic Phase of Chronic Myeloid Leukemia

acid – gout/uropathy Histamine increase with basophil 90% In normal cells, two red and two green signals indicate the location of the normal ABL and BCR genes, respectively [slideshare.net]

[…] turnover of glucocerebrocide* Collagen type III – correlates with spleen size and megakaryocytosis* Angiogenetic marrow – reduces with treatment B12 – immature cell leak Uric [slideshare.net]

[…] face *Massive - and in almost all patients Sternal tenderness – lower part – patient can detect Neutrophil alkaline phosphatase activity is low or absent (90%) - Activity increases [slideshare.net]

Acute Kidney Injury

Mild hyperuricemia, as a result of decreased renal uric acid excretion, is common in AKI. [renalandurologynews.com]

[…] proteinuria Munuaistiehyiden kuolio Last Update: 2012-04-10 Usage Frequency: 2 Quality: Maltese Ħaġra fil- kliewi, urina mhux normali, albuminerija, hypercalcinuria, nefrite, hyperuricemia [mymemory.translated.net]

Measurement of the urinary uric acid:creatinine ratio may help differentiate between hyperuricemia due to renal insufficiency and renal failure due to tumor lysis syndrome [renalandurologynews.com]

Arteriosclerosis

High uric acid and high gamma GT are both symptoms of poor antioxidant status. [drmyhill.co.uk]

Increased clotting tendency - anticardiolipin antibodies. Serum B12 levels. Antioxidant status - GSHPx (Se), SODase (Cn, Mn, Zn), CoQ10. [drmyhill.co.uk]

Chronic Myeloid Leukemia

Gout – increased cell turnover → excess purines → broken down to uric acid Increased susceptibility to infections – ↓ functional immune cells Shortness of breath/fatigue [geekymedics.com]

Sodium bicarbonate may be used to alkalinize the urine to increase uric acid excretion. [lecturio.com]

Hyperleukocytosis also increases the odds of spontaneous TLS and the number of blasts contributing to the uric acid load. [cancertherapyadvisor.com]

Hyperlipoproteinemia Type 5

Niacin can also increase uric acid levels and precipitate a gout attack. [aafp.org]

[…] preparations, such as Niaspan.48 Less common adverse effects include elevations of liver enzymes, increased levels of uric acid, gastrointestinal distress and worsened glucose [cmaj.ca]

Obtain uric acid level and fasting glucose levels before initiating therapy and 6 weeks after target dose is reached. [aafp.org]

Heat Stroke

Within 24 hrs, the levels of serum uric acid in both patients decreased dramatically, and their creatinine levels decreased and urine output increased concurrently. [ncbi.nlm.nih.gov]

Excretion of uric acid is also reduced in the presence of lactic acidaemia. [bja.oxfordjournals.org]

Continuous improvements in the uric acid levels, creatinine levels, and urine output were noted during hospitalization. [ncbi.nlm.nih.gov]