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11 Possible Causes for Urine Normetanephrine Increased

  • Acromegaly

    Context: Acromegaly is characterized by growth hormone (GH) and insulinlike growth factor-1 (IGF-1) hypersecretion, and GH and IGF-1 play important roles in regulating body composition and glucose homeostasis. Objective: The purpose of our study was to investigate body composition including ectopic lipids, measures[…][ncbi.nlm.nih.gov]

  • Hypertension

    Considering other important secondary causes like pheochromocytoma, hormonal studies were performed and the results showed increased serum norepinephrine, serum normetanephrine[ncbi.nlm.nih.gov] , and 24 h urine norepinephrine.[ncbi.nlm.nih.gov]

  • Haddad Syndrome

    Urine was collected daily for measurements of the catecholamines’ metabolites, as further metanephrine and normetanephrine are both metabolized to vanillylmandelic acid.[omicsonline.org] The specific tests for neuronal specific enolase in serum revealed its increased level: 40.37 ng/ml. The value for ferritin reached 487.2 μg/l.[omicsonline.org]

  • Hemangioblastoma

    A rise in plasma and urine metanephrines is thus indicative of increased tumoural production of catecholamines.[neurologyindia.com] Prior to the addressal of the brain-stem hemangioblastoma, the pheochromocytoma needs to be resected. [25] Within the chromaffin cells, NE and E are metabolized to normetanephrine[neurologyindia.com]

  • Glomus Jugulare Tumor

    Catecholamine assessments showed increased levels of epinephrine and normetanephrine in a 24 hour urine study.[neurology.org]

  • Turner Syndrome

    Considering other important secondary causes like pheochromocytoma, hormonal studies were performed and the results showed increased serum norepinephrine, serum normetanephrine[ncbi.nlm.nih.gov] , and 24 h urine norepinephrine.[ncbi.nlm.nih.gov]

  • Pheochromocytoma

    Diagnosis The diagnosis is initiated with biochemical testing of blood or urine for measurement of increased levels of catecholamines.[wikilectures.eu] Current guidelines from the National Comprehensive Cancer Network suggest testing for plasma-free metanephrine and normetanephrine, or for urine metanephrine, catecholamines[wikilectures.eu]

  • Multiple Endocrine Neoplasia

    . • Biochemical test – DHEA, normetanephrine, epinephrine, VMA, norepinephrine. • Pheochromocytoma – Biochemical tests – Increased urinary catecholamines and metabolites.[slideshare.net] • Tumor localization by CT/MRI • Carcinoids – CT or MRI of chest. • Endoscopy for gastric carcinoids • Urine 5HIAA, chromogranin A, calcitonin, corticotropin 28.[slideshare.net]

  • Multiple Endocrine Neoplasia Type 2A

    Urine metanephrines have been reported to be increased by tricyclic antidepressants and levodopa, as well as by extreme endogenous stress.[clinicaladvisor.com] Plasma levels of metanephrine and normetanephrine are elevated by MAO inhibitors, as well as amphetamines, epedrines, albuterol, cocaine, lidocaine, anesthetic gases, and[clinicaladvisor.com] Although normetanephrine is generally increased by tricyclic antidepressants and nonselective alpha blockers, metanephrine is not affected and is a more significant analyte[clinicaladvisor.com]

  • Multiple Endocrine Neoplasia Type 2B

    Urine metanephrines have been reported to be increased by tricyclic antidepressants and levodopa, as well as by extreme endogenous stress.[clinicaladvisor.com] Although normetanephrine is generally increased by tricyclic antidepressants and nonselective alpha blockers, metanephrine is not affected and is a more significant analyte[clinicaladvisor.com] Plasma levels of metanephrine and normetanephrine are elevated by monoamine oxidase (MAO) inhibitors, as well as amphetamines, ephedrines, albuterol, cocaine, lidocaine, anesthetic[clinicaladvisor.com]

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