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36 Possible Causes for Urine Porphobilinogen Increased

  • Porphyria

    The diagnosis is confirmed by increased amount of porphobilinogen in the urine during an attack.[symptoma.com] The diagnosis can be rapidly confirmed by demonstration of a markedly increased urinary porphobilinogen level by using a single-void urine specimen.[ncbi.nlm.nih.gov] The diagnosis is made by finding increased porphobilinogen excretion in a light‐protected random urine sample.[doi.org]

  • Acute Hepatic Porphyria

    Porphyrin and porphyrin precursor determination in urine showed an increase in porphobilinogen, as well as delta-aminolevulinic acid, coproporphyrin, and protoporphyrins in[revespcardiol.org] […] accumulation of the neurotoxic porphyrin precursors, aminolevulinic acid (ALA) and urine porphobilinogen (PBG).[hematologyandoncology.net] Because of the approximately half-normal enzyme activity in these acute hepatic porphyrias, the marked overexpression of ALAS1 results in the increased production and subsequent[hematologyandoncology.net]

  • Acute Intermittent Porphyria

    The biochemical hallmark of an acute attack is an increase in urine porphobilinogen (PBG), together with an increase in urinary excretion of δ-aminolaevulinic acid (ALA) and[ncbi.nlm.nih.gov] Interestingly, asymptomatic mutation carriers with increased urine porphobilinogen did not have circulating fluorocytes.[ncbi.nlm.nih.gov] Specific treatment with heme preparations should be instituted as soon as increased excretion of porphobilinogen through urine sampling is confirmed.[ncbi.nlm.nih.gov]

  • Anxiety Disorder

    Diagnoses are achieved based on urine porphobilinogen measurements; urinary porphobilinogen levels are greatly increased but may be normal between attacks.[ncbi.nlm.nih.gov]

  • Mental Disorder

    Diagnoses are achieved based on urine porphobilinogen measurements; urinary porphobilinogen levels are greatly increased but may be normal between attacks.[ncbi.nlm.nih.gov]

  • Chronic Anxiety

    Diagnoses are achieved based on urine porphobilinogen measurements; urinary porphobilinogen levels are greatly increased but may be normal between attacks.[ncbi.nlm.nih.gov]

  • Constitutional Anemia due to Iron Metabolism Disorder

    (PBG) deaminase Increased incidence in psychiatric patients Resultant excretion of increased amounts of ALA and PBG in urine Acute intermittent porphyria - clinical features[brainscape.com] […] the problem Acute Intermittent Porphyria (AIP) - incidence and pathology Most common in peoples of Scandinavian, British, and eastern European descent Due to deficiency of porphobilinogen[brainscape.com]

  • Anxiety Neurosis

    Diagnoses are achieved based on urine porphobilinogen measurements; urinary porphobilinogen levels are greatly increased but may be normal between attacks.[ncbi.nlm.nih.gov]

  • Hereditary Coproporphyria

    Urine porphobilinogen was increased, consistent with an acute attack of porphyria. Urine porphyrins were raised at 156 nmol/mmol creatinine (normal range 0–30).[journals.lww.com] In the initial screening procedure, it is reasonable to probe 5-aminolevulinic acid and porphobilinogen urine levels, which are expected to be increased by at least a factor[symptoma.com] A defect in this enzyme results in accumulation of the porphyrin precursors porphobilinogen and 5-aminolevulinic acid; increase of fecal and urinary excreation of coproporphyrins[smpdb.ca]

  • Refractory Megaloblastic Anemia

    (PBG) deaminase Increased incidence in psychiatric patients Resultant excretion of increased amounts of ALA and PBG in urine Acute intermittent porphyria - clinical features[brainscape.com] […] the problem Acute Intermittent Porphyria (AIP) - incidence and pathology Most common in peoples of Scandinavian, British, and eastern European descent Due to deficiency of porphobilinogen[brainscape.com]

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