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11 Possible Causes for Urine Uracil Increased

  • Dihydropyrimidine Dehydrogenase Deficiency

    Tests revealed a marked excretion of thymine with significantly increased uracil excretion in the urine, indicating a pyrimidine catabolic disorder, i.e., dihydropyrimidine[ncbi.nlm.nih.gov] Additional studies revealed a significant defect in pyrimidine catabolism with a 3.3- and 365-fold increase in the levels of uracil in plasma and urine, respectively, compared[ncbi.nlm.nih.gov] […] dehydrogenase * Brain dysmyelination * Low blood platelet level * Reduced number of neutrophils in blood * Fluoouracil toxicity * Abnormal brain (cerebral) function * High uracil[checkorphan.org]

  • Gangliosidosis

    Tests revealed a marked excretion of thymine with significantly increased uracil excretion in the urine, indicating a pyrimidine catabolic disorder, i.e., dihydropyrimidine[ncbi.nlm.nih.gov]

  • Hereditary Orotic Aciduria

    Deficiency of dihydropyrimidine dehydrogenase causes an increase in blood and urine levels of uracil and thymine.[ommbid.mhmedical.com] Increased excretion of orotic acid, uracil, and uridine also accompanies a deficiency in liver mitochondrial ornithine transcarbamoylase, an enzyme of urea cycle that catalyzes[usmle.biochemistryformedics.com] Orotic aciduria refers to an excessive excretion of Orotic acid in urine.[usmle.biochemistryformedics.com]

  • Citrin Deficiency

    Other important urinary biomarkers that should be measured for differential diagnosis of hyperammonemias, including orotate, uracil, and β-ureidopropionate, were not increased[ncbi.nlm.nih.gov] The present study shows that noninvasive urine metabolomics, together with an analysis of selected metabolites or groups of metabolites, provides a more reliable and rapid[ncbi.nlm.nih.gov]

  • Beta-Ureidopropionase Deficiency

    In the urine of the neonate with betaUPase deficiency, betaUP and betaUIB were persistently increased.[wwww.unboundmedicine.com] Deficiency of dihydropyrimidine dehydrogenase causes an increase in blood and urine levels of uracil and thymine.[ommbid.mhmedical.com] It is known that thymine and uracil increase markedly in DHPDase deficiency, and 5,6-dihydrothymine and 5,6-dihydrouracil increase in DHPase deficiency.[wwww.unboundmedicine.com]

  • Dihydropyrimidinuria

    Deficiency of dihydropyrimidine dehydrogenase causes an increase in blood and urine levels of uracil and thymine.[ommbid.mhmedical.com] […] concentrations of uracil and thymine can be detected in urine.[clinchem.aaccjnls.org] For example, in patients with a complete deficiency of dihydropyrimidinase, highly increased concentrations of 5,6-dihydrouracil and 5,6-dihydrothymine and moderately increased[clinchem.aaccjnls.org]

  • Carbamoyl Phosphate Synthetase Deficiency

    Increased excretion of orotic acid, uracil, and uridine also accompanies a deficiency in liver mitochondrial ornithine transcarbamoylase, an enzyme of urea cycle that catalyzes[usmle.biochemistryformedics.com] Orotic aciduria refers to an excessive excretion of Orotic acid in urine.[usmle.biochemistryformedics.com]

  • Adenine Phosphoribosyl Transferase Deficiency

    In all samples, uracil and thymine were clearly increased (uracil, 95–626 μmol/mmol creatinine; thymine, 270–470 μmol/mmol creatinine).[clinchem.aaccjnls.org] An example of a 1 H-NMR spectrum of a urine sample of one of these cases has been published previously ( 12 ).[clinchem.aaccjnls.org] In nondiseased urine samples, thymine cannot be detected with NMR spectroscopy, whereas uracil is observed in trace amounts in some samples ( Dihydropyrimidinase (EC 3.5.2.2[clinchem.aaccjnls.org]

  • 2,8-Dihydroxyadenine Urinary Stones

    In all samples, uracil and thymine were clearly increased (uracil, 95–626 μmol/mmol creatinine; thymine, 270–470 μmol/mmol creatinine).[clinchem.aaccjnls.org] An example of a 1 H-NMR spectrum of a urine sample of one of these cases has been published previously ( 12 ).[clinchem.aaccjnls.org] In nondiseased urine samples, thymine cannot be detected with NMR spectroscopy, whereas uracil is observed in trace amounts in some samples ( Dihydropyrimidinase (EC 3.5.2.2[clinchem.aaccjnls.org]

  • Deficiency of Sulfite Oxidase

    […] samples as reflected by increased levels of compounds such as succinic acid, benzoic acid, 2-hydroxyglutaric acid, and uracil [ Sass et al 2010 ].[ncbi.nlm.nih.gov] […] mucolite drug 2-mercaptoethane sulfonate; Certain antibiotics such as cefotaxime, cefuroxime, ampicillin, and benzylpenicillin [ Tan et al 2005 ]; and Bacterial degradation of urine[ncbi.nlm.nih.gov]

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