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80 Possible Causes for Vacuolation of Granular Layer

  • Bullous Erythroderma Ichthyosiformes

    These become mature corps ronds by further vacuolization when in the granular layer.[] […] and hyperkeratosis with ballooning degeneration of the granular and spinous layers of the epidermis [2].[] Of considerable diagnostic significance is the presence of dyskeratosis or vacuolization of cells in the underlying spinous layer, just beyond the lower end of the parakeratotic[]

  • Ichthyosis Vulgaris

    Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[]

  • Microglandular Adenosis

    The glands are lined by a single layer of cells with distinctly vacuolated or granular cytoplasm.[] […] of cuboidal / flat cells with vacuolated / granular cytoplasm and bland nuclei No apocrine snouts, no nucleoli, no / variable myoepithelial layer but thick basement membrane[] The glands are lined by a single layer of small uniform cuboidal or flat cells with vacuolated or granular cytoplasm, lacking apocrine-type ‘snouts’.[]

  • Proliferating Trichilemmal Cyst

    […] cell layer (trichilemmal keratinization) with formation of parakeratotic cells without granular cell layer [Figure 3].[] Glycogen-rich vacuolated cells were also seen [Figure 4]. The diagnosis of proliferating trichilemmal tumor (PTT) was made.[] […] histopathology revealed well-demarcated tumor with variably sized lobules of squamous epithelium [Figure 2] undergoing an abrupt change into eosinophilic amorphous keratin without granular[]

  • Glucagonoma

    A skin biopsy performed on a peritibial lesion showed a spongiotic epidermis with vacuolization of the granular layer and presence of necrotic keratinocytes in the horny layer[]

  • Coronary Cataract

    Characteristically, these forms of senile opacity are usually restricted to a single layer and are composed of vacuoles and granular material.[]

  • Binswanger Disease

    Pick bodies (granular layer of dentate gyrus). Extensive astrogliosis (striatonigral degeneration, hepatic encephalopathy).[] Granulovacuolar degeneration (granules within cytoplasmic vacuoles, mainly in the hippocampal pyramidal neurons, seen in AD). Cores of amyloid plaqyes.[] Corpora amylacea in the cornu ammonis may be increased in neurodegenerative diseases. [9] Lewy body Cotton wool plaques Neurofibrillary tangles Spongiform vacuolation Dementia[]

  • Epidermodysplasia Verruciformis

    The vacuolated cells are present in the upper malpighian and granular layer [Figure 3] a. The keratinocytes have abundant basophilic cytoplasm.[] layer.[] […] cells in the upper malpighian and granular layer (H and E, 10).[]

  • Verruca Vulgaris

    layer with vacuolated superficial keratinocytes with pyknotic nuclei (koilocytes) Dilated blood vessels within papillary dermis Tiers of parakeratosis overly papillary epidermal[] Cells with prominent perinuclear vacuolization around pyknotic, basophilic, centrally located nuclei can be in the granular layer.[] In the upper stratum malpighii, including the granular layer, there is diffuse vacuolization of the cells.[]

  • Plantar Wart

    […] nuclei in the horny layer and amorphous eosinophilic cytoplasmic inclusions in the cells with peripherally located nuclei in the granular and prickle cell layers.[] Their histopathologic features were identical to those found in the wall of the cysts reported previously, namely hyperkeratosis with vacuolated structure with or without[]

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