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11 Possible Causes for Vacuolation of Granular Layer, Visual Acuity Decreased

  • Coronary Cataract

    Characteristically, these forms of senile opacity are usually restricted to a single layer and are composed of vacuoles and granular material.[] Most affected individuals noticed their visual impairments before the age of ten, and their visual acuity decreased gradually until surgery.[] Visual acuity in the affected individuals before surgery ranged from 0.01 to 0.8.[]

  • Stromal Keratitis

    Historically, researchers have divided the cytoplasm into two parts, consisting of a granular inner endoplasm and a layer of clear ectoplasm.[] The patient described onset of decreased visual acuity after the first 2 postoperative weeks, failed to improve with high-dose topical steroid drops, and had significantly[] […] or prevent recurrence and maintain useful visual acuity, avoiding frequent relapses leading to blindness.[]

  • Epidermal Nevus Syndrome

    ; perinuclear vacuolization of the keratinocytes in spinous and granular layers and increased number of basophilic keratohyalin granules in the stratum granulosum.[] Her hearing was impaired because of serous otitis media and her visual acuity decreased because of hard yellow exudate in the macula as a result of decompensation and plasma[] Figure 4: Photomicrograph showing compact hyperkeratosis and vacuolization of the keratinocytes (H&E, 10 ) Click here to view Figure 5: Photomicrograph showing compact hyperkeratosis[]

  • Palmoplantar Keratosis

    Corneal neovascularization, ulceration and scarring may lead to decreased visual acuity.[] […] irregularly shaped keratohyalin granules located in the granular layer of the epidermis and perinuclear vacuolization of the keratinocytes.[] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[]

  • Autosomal Dominant Keratitis

    Subepithelial fluid-filled bullae form on the corneal surface as the corneal stroma (the deeper dense connective tissue layer of the cornea) swells, leading to decreased visual[] Electron microscopy showed incipient vacuolation in the basal layer.[] Over time, affected individuals have decreased visual acuity. In severe cases of keratitis can lead to blindness.[]

  • Congenital Ichthyosiform Erythroderma

    Visual acuity was 6/60 in each eye, and there were nuclear and zonular lens opacities. Otherwise, the eye examination was normal.[] Characteristic findings of epidermolytic hyperkeratosis were seen which included hyperkeratosis with granular layer degeneration, vacuolization and eosinophilic globules.[] […] and hyperkeratosis with ballooning degeneration of the granular and spinous layers of the epidermis [2].[]

  • Ichthyosis

    RESULTS: A 30-year-old man presented with generalized erythro-hyperkeratosis and deafness and complaints of decreased visual acuity, tearing, and photophobia.[] Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[] […] or binucleated cells in the granular and suprabasal layers, although no granular degeneration is seen. 67, 68 Characteristically, the electron microscopic study of both normal‐looking[]

  • Necrobiotic Xanthogranuloma

    In addition to the cutaneous lesions, which can have bilateral or unilateral ocular involvement, other ocular findings include diplopia, scleritis, decreased visual acuity[] (D) Large vacuolated cells with grayish cytoplasm and vesicular nuclei in the upper spinal and granular layers (original magnification x100).[] […] nuclei in the upper spinal and granular layers; changes characteristic of EDV ( Figure 2D ).[]

  • Carcinoma in Situ of Sphenoid Sinus

    visual acuity), and dysesthesia of the maxillary division of the trigeminal nerve.[] […] cell layer, and often contain numerous vacuolated cells suggestive of koilocytes.[] […] been cited as the most common presenting factor. 6,10,16,17 Clinical signs may include nasal discharge, epistaxis, orbital disorders (including oculomotor restriction and decreased[]

  • Familial Progressive Hyper- and Hypopigmentation

    […] keratinocytes and extracellular granular material in the basal layer of the normal skin adjacent to areas of vitiligo. 254 If serial sections are examined, a lymphocyte will[] acuity is decreased to 20/400 OVA 1B tyrosinase activity is reduced but not absent.[] […] dermoepidermal interface was observed in 89% of these cases. 253 Focal spongiosis is sometimes present in the marginal areas of vitiligo. 250 Ultrathin sections will often show vacuolated[]

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