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65 Possible Causes for Vacuolation of Granular Layer, Weight Loss

  • Glucagonoma

    This report describes a classic presentation consisting of dermatitis, glossitis, stomatitis, angular cheilitis, anemia, and weight loss that was associated with the finding[ncbi.nlm.nih.gov] A skin biopsy performed on a peritibial lesion showed a spongiotic epidermis with vacuolization of the granular layer and presence of necrotic keratinocytes in the horny layer[jmedicalcasereports.biomedcentral.com] We present a 67-year-old diabetic patient with extensive cutaneous lesions, weight loss, and poor glycemic control.[ncbi.nlm.nih.gov]

  • Malignant Peritoneal Mesothelioma

    The clinical presentation of the disease is not characteristic: nonspecific abdominal pain, weight loss, and abdominal distension are common.[ncbi.nlm.nih.gov] These cells were either spindle shaped or epithelioid with a vacuolated cytoplasm and oval nuclei with granular chromatin and prominent nucleoli.[scielo.br] Because it presents with vague symptoms such as abdominal pain, anorexia, and weight loss, it is generally advanced at diagnosis.[ncbi.nlm.nih.gov]

  • Coronary Cataract

    Loss Weight Loss Secrets Food For Eyes Optometry Eyes Health Forward Eat For Your Eyes" Online Recipe Contest Iris Student-centered Resources Healthy Living Health And Fitness[pinterest.se] Characteristically, these forms of senile opacity are usually restricted to a single layer and are composed of vacuoles and granular material.[embryology.med.unsw.edu.au] Sensitivity Opthalmic Technician Forward Early symptoms of keratoconus include mildly blurred vision, slight vision… Eyes Care Healthy Eyes Online Recipes Online Contest Amazing Weight[pinterest.se]

  • Ichthyosis Vulgaris

    loss Vitamin A deficiency Treatment with nicotinic acid eg to lower cholesterol Extremely rarely, other serious conditions What are the signs?[ichthyosis.org.uk] Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[medcaretips.com] Environmental factors: excessive washing, excessive heat, cold windy weather, chlorine from swimming pool, air conditioning Metabolic factors eg thyroid disease, excessive weight[ichthyosis.org.uk]

  • Balantidiasis

    Clinical features, when present, include persistent diarrhea, occasionally dysentery, abdominal pain, and weight loss. Symptoms can be severe in debilitated persons.[healthdictionary.info] vacuoles Cyst wall made of one or two layers Diagnosis Occasionally found in feces, often found in tissue biopsies of infected individuals Diagnostically found in feces of[stanford.edu] Rarely, symptoms may include dysentery, abdominal pain, weight loss, and diarrhea. For persons of weak health, symptoms of Balantidiasis may be worse.[medic8.com]

  • Fatal Familial Insomnia

    Sudden insomnia that gets worse over time Rapidly worsening dementia Vivid dreaming Lack of appetite Weight loss Too high or low body temperature Anxiety Depression Panic[patientworthy.com] A few vacuolated neurons in the inferior olivary nuclei had discrete granular PrP res deposits on the surface and/or in the cytoplasmic vacuoles.[brain.oxfordjournals.org] The symptoms are continuous sweating, tremor, behavioral disorders, cognitive deficit, and rapid, unstoppable weight loss.[marionegri.it]

  • Howell-Evans Syndrome

    loss , clubbing of toes, abnormality of mouth, abdominal distension, abdominal heaviness, anemia , difficulty swallowing, vomiting , nausea , and parakeratosis .[xpertdox.com] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[emedicine.medscape.com] He also reported a 6.8-kg (15-lb) weight loss, anorexia, and progressive hoarseness over the previous 6 months.[nejm.org]

  • Microglandular Adenosis

    […] cytokeratin-negative and low KI67 proliferation fraction) and genetic signature (highly recurrent PIK3CA mutations/1q gain/16q loss). 38 We have later hypothesized that breast[nature.com] The glands are lined by a single layer of cells with distinctly vacuolated or granular cytoplasm.[ncbi.nlm.nih.gov] […] of cuboidal / flat cells with vacuolated / granular cytoplasm and bland nuclei No apocrine snouts, no nucleoli, no / variable myoepithelial layer but thick basement membrane[pathologyoutlines.com]

  • Proliferating Trichilemmal Cyst

    She had no history of weight loss, gastrointestinal complaints, breathlessness, nausea, vomiting and recurrent fever. She had no eye complaints.[idoj.in] […] cell layer (trichilemmal keratinization) with formation of parakeratotic cells without granular cell layer [Figure 3].[e-ijd.org] Glycogen-rich vacuolated cells were also seen [Figure 4]. The diagnosis of proliferating trichilemmal tumor (PTT) was made.[e-ijd.org]

  • Condyloma Latum

    He had loss of appetite with no weight loss. His past medical history was unremarkable. He was not taking any medication.[ncbi.nlm.nih.gov] High-magnification view of the granular layer demonstrates coarse hyaline granules with scattered koilocytic changes (hyperchromatic nuceli with vacuolization).[dermatologyadvisor.com] loss, headache, meningismus and enlarged lymph nodes.[ncbi.nlm.nih.gov]

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