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2,692 Possible Causes for Vacuolization

  • Distal Myopathy

    Extremely large variations in muscle fibre diameter (the size of some fibres exceeding 200-250 microns), rimmed vacuoles, necrotic fibres invaded by macrophages, atrophic[ncbi.nlm.nih.gov] The vacuoles consisted of sarcoplasmic spaces without limiting membranes, containing granular and fibrillar material.[ncbi.nlm.nih.gov] Affected patients had late-onset distal lower extremity weakness, myopathic features on EMG, and muscle pathology demonstrating rimmed vacuoles with both TAR DNA-binding protein[ncbi.nlm.nih.gov]

  • Danon Disease

    […] clusters of autophagic vacuoles, indicative of autolysosomes.[ncbi.nlm.nih.gov] However, the first muscle biopsy with large cytoplasmic vacuoles confused the diagnosis and led to the second biopsy that allowed for the final diagnosis.[ncbi.nlm.nih.gov] Two patients underwent heart transplantation; histology of explanted hearts demonstrated severe interstitial fibrosis, hypertrophic cardiomyocytes with cytoplasmic vacuoles[ncbi.nlm.nih.gov]

  • Inclusion Body Myositis

    The coexistence of ring fibres, rimmed vacuoles and inclusion-body myositis-type inclusions in a child with congenital myopathy has not been previously reported.[ncbi.nlm.nih.gov] Abstract OBJECTIVE: Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature.[ncbi.nlm.nih.gov] Rimmed vacuoles were found in 49 patients (60.5%).[ncbi.nlm.nih.gov]

  • Inclusion Body Myopathy

    The most significant muscle pathology is the presence of rimmed vacuoles, which appear to play a major role in muscle atrophy and weakness.[ncbi.nlm.nih.gov] HIBM was originally described as rimmed vacuole myopathy sparing the quadriceps; therefore, the two diseases have been suspected to be allelic.[ncbi.nlm.nih.gov] Our results revealed that patients' myoblasts accumulate large vacuoles.[ncbi.nlm.nih.gov]

  • Pearson Syndrome

    Important clues to the diagnosis include cytoplasmic vacuolization of erythroid and myeloid precursors along with ringed sideroblasts on bone marrow evaluation.[bloodjournal.org] […] organic aciduria (i.e., large amounts of lactic, 3-hydroxy-butyric, beta-hydroxy-butyric, fumaric, malic, succinic, and, often, 3-methyl-glutaconic acids), together with cytoplasmic[path.upmc.edu] Characteristic vacuolization of a hematopoietic precursor in the bone marrow.[emedicine.com]

  • Hibernoma

    Cytology [ edit ] The fine needle aspiration smears show small, round, brown fat-like cells, with uniform, small cytoplasmic vacuoles and regular, small, round nuclei.[en.wikipedia.org] Pathologic findings include sheets of multivacuolated cells with centrally placed nuclei and numerous tiny surrounding cytoplasmic vacuoles overlying bony trabeculae.[ncbi.nlm.nih.gov] Granular cell tumour : Distinguished by complete absence of lipid cytoplasmic vacuoles. The granular cells are diffusely positive with S-100 protein.[histopathology-india.net]

  • Oculopharyngodistal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] Myopathological findings showed rimmed vacuoles with varying degrees of muscular dystrophic changes.[ncbi.nlm.nih.gov] Histological features included basophilic-rimmed vacuoles, but the typical OPMD intranuclear filaments were absent.[ncbi.nlm.nih.gov]

  • Pleomorphic Liposarcoma

    vacuole or vacuoles Must be sharply defined Must indent and distort nucleus May be focal or widespread S100 may highlight lipoblasts May contain cytoplasmic eosinophilic[surgpathcriteria.stanford.edu] vacuoles Sarcomatous component contains atypical spindled, round, and pleomorphic tumor cells Numerous mono- and multinucleated tumor giant cells High degree of nuclear atypia[basicmedicalkey.com] The tumor was removed and the histological examination revealed a highly cellular tumor with heterogenous histology, with a few vacuolated cells and many malignant features[ncbi.nlm.nih.gov]

  • Hereditary Mucoepithelial Dysplasia

    Papanicolaou smears show lack of epithelial cell maturation, poikilocytosis, anisocytosis, large paranuclear cytoplasmic vacuoles, and cytoplasmic strand-shaped inclusions[ncbi.nlm.nih.gov] Vaginal, oral, and urinary cytological smears show a lack of epithelial cell maturation, large paranuclear cytoplasmic vacuoles, and cytoplasmic strand-shaped inclusions.[doi.org] Ultrastructural features include a paucity of desmosomes, intercellular accumulations of amorphous material, cytoplasmic vacuoles, and paranuclear lesions with strands of[ncbi.nlm.nih.gov]

  • Hemangioblastoma

    Microscopically, the neoplasm was seen to be composed of vascular channels associated with foamy stromal cells, containing clear cytoplasmic vacuoles.[ncbi.nlm.nih.gov] Tumor was composed of numerous capillaries and stromal cells with cytoplasmic vacuolization.[ncbi.nlm.nih.gov] But the tumor cells commonly show lipid cytoplasmic vacuoles; mitotic activity, infiltrative growth and vascular invasion are often identifiable.[diagnosticpathology.biomedcentral.com]

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