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17 Possible Causes for Vacuolization, Weight Loss due to Dysphagia

  • Oculopharyngodistal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] Myopathological findings showed rimmed vacuoles with varying degrees of muscular dystrophic changes.[ncbi.nlm.nih.gov] Histological features included basophilic-rimmed vacuoles, but the typical OPMD intranuclear filaments were absent.[ncbi.nlm.nih.gov]

  • Hemangioblastoma

    Microscopically, the neoplasm was seen to be composed of vascular channels associated with foamy stromal cells, containing clear cytoplasmic vacuoles.[ncbi.nlm.nih.gov] loss or aspiration); stage III decompensated abnormal function with weight loss of 10% or less of body weight over 6 months due to dysphagia, or daily cough, gagging, or[neurologyindia.com] Tumor was composed of numerous capillaries and stromal cells with cytoplasmic vacuolization.[ncbi.nlm.nih.gov]

  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] Surgery may also help relieve problems due to dysphagia and should be considered if there is marked weight loss, near-fatal choking, or recurrent pneumonia.[genpharmservices.com] Innervated cultures had large cytoplasmic vacuoles in a number of muscle fibers.[ncbi.nlm.nih.gov]

  • Liposarcoma

    […] lesions occurred in the tongue of a 30-year-old man and in the triceps of a 67-year-old woman and were characterized by bland, epithelioid cells with striking intracytoplasmic vacuolization[ncbi.nlm.nih.gov] RESULTS: An 81-year-old man presented with a 5-month history of dysphagia and 30-kg weight loss, due to a giant pedunculated liposarcoma of the hypopharynx, which is resected[ncbi.nlm.nih.gov] Microscopically, this was a well-defined, lobulated tumour comprising solid sheets of large pleomorphic and spindle cells with bizarre forms, vacuolated cytoplasm, and ample[ncbi.nlm.nih.gov]

  • Yolk Sac Tumor

    They are lined by a single layer of columnar cells with subnuclear and supranuclear cytoplasmic vacuolation resembling early secretory endometrium.[ijpmonline.org] The patient presented with a cough with whitish sputum, history of hemoptysis, loss of weights, and dysphagia.[exp-oncology.com.ua] Cells with large cytoplasmic vacuolation were infrequent and few hobnail shaped tumor cells. 5,7 On the other hand, YST showed more dyscohesive cells with marked cellular[biocoreopen.org]

  • Intestinal Pseudo-Obstruction

    Microscopic (histologic) description Visceral myopathy: vacuolar degeneration with swelling and loss of muscle cells, fibrosis of outer longitudinal muscle layer; other cases show cytoplasmic[pathologyoutlines.com] Nutrition supplementation is required for many patients with CIP due to symptoms of dysphagia, nausea, vomiting, and weight loss.[doi.org] Enteric myopathies Histopathological analysis of the enteric muscle layer may reveal the existence of muscular abnormalities (i.e. smooth muscle fibrosis and vacuolization[doi.org]

  • Irritable Bowel Syndrome

    Following phagocytosis, Salmonella forms the characteristic Salmonella Containing Vacuole (SCV) in macrophages, in which it replicates while effectively evading host immune[doi.org] Patients with alarm features (such as weight loss, dysphagia, vomiting, bleeding), familiarity for gastrointestinal neoplasia and inflammatory bowel disease were excluded[doi.org] Vacuolation and protein deposition were found in the apical cytoplasm of some luminal enterocytes.[doi.org]

  • Polymyositis

    KEYWORDS: anti-Ku antibody; dropped head syndrome; rimmed vacuole; scleroderma-polymyositis overlap syndrome[ncbi.nlm.nih.gov] They are clinically different due to the systemic involvement present in DM involving skin, developing more severe arthralgia, dysphagia, weight loss and generating high values[doi.org] Arahata and Engel state that all their patients with a diagnosis of inclusion body myositis had the typical histological findings, including vacuoles and filamentous inclusions[doi.org]

  • Amyotrophic Lateral Sclerosis

    Cytoplasmic vacuoles were found in the remaining anterior horn motor neurons of the lumbar spinal cord.[ncbi.nlm.nih.gov] Weight loss in ALS is caused by muscle wasting due to motor neuron death, increased resting energy expenditure, and decreased food intake.[en.wikipedia.org] Arrows point to cytoplasmic vacuoles that accumulate in cells treated with lithium or Rap (a known autophagy inducer).[dx.doi.org]

  • Chronic Intestinal Pseudo-Obstruction

    Microscopic (histologic) description Visceral myopathy: vacuolar degeneration with swelling and loss of muscle cells, fibrosis of outer longitudinal muscle layer; other cases show cytoplasmic[pathologyoutlines.com] Nutrition supplementation is required for many patients with CIP due to symptoms of dysphagia, nausea, vomiting, and weight loss.[ncbi.nlm.nih.gov] In addition, one patient had severe atrophy of the inner muscle layer and the other obvious vacuolation of the muscularis propria.[ncbi.nlm.nih.gov]

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