Create issue ticket

39 Possible Causes for Vacuolization of Bone Marrow Precursors

  • Alcohol Abuse

    Microscopic (histologic) description May cause hypocellular marrow or reactive myeloblastosis with up to 34% blasts Vacuoles in proerythroblasts and other precursors Also[pathologyoutlines.com] […] ringed sideroblasts and iron granules in plasma cells Microscopic (histologic) images Images hosted on other servers : Marked megaloblastic features Markedly hypercellular Bone[pathologyoutlines.com] marrow: intracytoplasmic vacuoless Multiple coarses granules Plasma cell: iron granules forming plaque Hemosiderin granules in normoblast Peripheral smear description Leukopenia[pathologyoutlines.com]

  • Sideroblastic Anemia

    Important clues to the diagnosis include cytoplasmic vacuolization of erythroid and myeloid precursors along with ringed sideroblasts on bone marrow evaluation.[bloodjournal.org] The syndrome is characterized by anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts.[ncbi.nlm.nih.gov] Characteristic vacuolization of a hematopoietic precursor in the bone marrow.[emedicine.com]

  • Pearson Syndrome

    Bone marrow aspirate revealed a cellular marrow with mild erythroid hyperplasia and characteristic cytoplasmic vacuolations in myeloid and occasional erythroid precursors.[bloodjournal.org] Characteristic vacuolization of a hematopoietic precursor in the bone marrow.[emedicine.medscape.com] […] of marrow precursors and dysfunction of the exocrine pancreas, and caused by mitochondrial (mt) DNA deletions and duplications.[deepdyve.com]

  • Constitutional Anemia due to Iron Metabolism Disorder

    Careful examination of the bone marrow to search for vacuolization in hematopoietic precursors is important to identify Pearson syndrome.[bloodjournal.org]

  • Hypocupremia

    Abnormalities observed on bone marrow examination including vacuoles in myeloid precursors, iron-containing plasma cells, a decrease in granulocyte precursors and ring sideroblasts[mayoclinic.pure.elsevier.com] – 9 Similarly, bone marrow morphology consisted of erythroid and myeloid dysplasia in all patients, normal to increased cellularity, vacuolization of erythroid precursors,[doi.org] Abnormalities observed on bone marrow examination including vacuoles in myeloid precursors, iron‐containing plasma cells, a decrease in granulocyte precursors and ring sideroblasts[doi.org]

  • Myelodysplasia

    […] or diffuse cytoplasmic staining) within erythroid precursors in the bone marrow aspirate (has no bearing on paraffin fixed bone marrow biopsy).[wiki.clinicalflow.com] Periodic acid-Schiff (PAS) (globular in vacuoles or diffuse cytoplasmic staining) within erythroid precursors in the bone marrow aspirate (has no bearing on paraffin-fixed[en.wikipedia.org] […] percursors and karyorrhexis Erythroid nuclear budding Erythroid nuclear strings or internuclear bridging (also seen in congenital dyserythropoietic anemias) PAS (globular in vacuoles[wiki.clinicalflow.com]

  • Refractory Anemia

    Patient 2 had prolonged cytopenias and underwent bone marrow transplantation (BMT).[ncbi.nlm.nih.gov] Patient 3 had features suggestive of refractory anemia associated with mitochondrial cytopathy, including normal cytogenetics with pronounced vacuolization of marrow precursors[ncbi.nlm.nih.gov]

  • Agranulocytosis

    Periodic acid-Schiff (PAS) (globular in vacuoles or diffuse cytoplasmic staining) within erythroid precursors in the bone marrow aspirate (has no bearing on paraffin-fixed[en.wikipedia.org]

  • Pancytopenia

    Histopathologic examination of bone marrow aspirate revealed a normocellular marrow and dyserythropoiesis with vacuolized and dysplastic erythroid precursors ( Figure, panel[jamanetwork.com] These showed trilineage hypoplasia and prominent dysplasia (see inset panel, arrows), including multiple vacuolated myeloid precursors (see large panel, arrows).[bloodjournal.org] Bone marrow histopathology can show ringed sideroblasts, hypocellular marrow, and vacuolized erythroid and granulocytic precursors. 7 Such dysplastic changes may be interpreted[jamanetwork.com]

  • Microangiopathic Hemolytic Anemia

    A bone marrow aspirate revealed myeloid precursors filled with melanin-bearing vacuoles.[ncbi.nlm.nih.gov] Immunophenotypic analysis of the patient's bone marrow by flow cytometry revealed a paucity of hematopoietic cells.[ncbi.nlm.nih.gov] The histopathology of the patient's bone marrow revealed sheets of malignant cells immunoreactive with S-100, HMB-45, and vimentin and also staining positively for melanin[ncbi.nlm.nih.gov]

Further symptoms