Vertical Supranuclear Ophthalmoplegia: Causes & Reasons

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Possible Causes for Vertical Supranuclear Ophthalmoplegia

Niemann-Pick Disease Type C

At age 45, he had mild dementia and dysarthria, vertical supranuclear ophthalmoplegia, axonal sensorimotor polyneuropathy, and cerebellar ataxia. [ncbi.nlm.nih.gov]

He was subsequently diagnosed with NPC as the emerging features of dementia, ataxia, dysarthria, and vertical supranuclear ophthalmoplegia were recognized. [ncbi.nlm.nih.gov]

In two siblings affected with dementia, epilepsy and vertical supranuclear ophthalmoplegia, foam cells and sea-blue histiocytes were found in the bone marrow. [ncbi.nlm.nih.gov]

Parinaud Syndrome

Vertical supranuclear ophthalmoplegia อาจมีอาการที่คล้าย dorsal midbrain syndrome ได้แก่ metabolic disorders เช่น Niemann-Pick disease, Wilson’s disease, kernicterus, and [neurologycoffecup.wordpress.com]

Vertical supranuclear ophthalmoplegia has also been associated with metabolic disorders, such as Niemann-Pick disease, Wilson's disease, kernicterus, and barbiturate overdose [en.wikipedia.org]

Vertical supranuclear ophthalmoplegia has also been associated with metabolic disorders, such as Niemann-Pick disease, Wilson’s disease, kernicterus, and barbiturate overdose [neurocirugia.com]

Sea-blue histiocytosis

A Neurovisceral storage disease with vertical supranuclear ophthalmoplegia and its relationship to Niemann Pick disease: A report of nine patients. [annalsofian.org]

Abstract A case of partial sphingomylinase deficiency with supranuclear vertical ophthalmoplegia, perceptive hearing loss and renal failure is reported. [ncbi.nlm.nih.gov]

supranuclear ophthalmoplegia is 75%. [10] The prevalence in India is not known but in western countries it varies from one in 5,00,000 to one in 7,50,000. [neurologyindia.com]

Pick Disease of The Brain

The most typical phenotype is characterised by hepatosplenomegaly, vertical supranuclear ophthalmoplegia, progressive ataxia, dystonia, and dementia and manifests in late [jnnp.bmj.com]

supranuclear ophthalmoplegia, cognitive impairment, and psychotic illness. 2, 3 Because of the rarity of adult patients, few studies have examined brain changes in the disease [ajnr.org]

Vertical supranuclear ophthalmoplegia, which was absent in our patient, is an important sign in infantile and juvenile Niemann-Pick disease type C, but it is often missing [jnnp.bmj.com]

Classic Progressive Supranuclear Palsy Syndrome

supranuclear ophthalmoplegia, pseudobulbar palsy, dysarthria, dystonic rigidity-in-extension of the neck, and mild dementia."3 By the early 1960s six of these patients had [movementdisorders.org]

ICD10 - G23.1 Disease Progressive supranuclear palsy (PSP) or Steele-Richardson-Olszewski syndrome is characterized by a progressive supranuclear ophthalmoplegia typically [eyewiki.aao.org]

[…] saccades and square wave jerks on ocular examination (early signs) Supranuclear ophthalmoplegia (classic gaze palsy in PSP) Downgaze typically involved before upgaze Improvement [emedicine.medscape.com]

Nothnagel Syndrome

Vertical supranuclear ophthalmoplegia has also been associated with metabolic disorders, such as Niemann-Pick disease, Wilson's disease, kernicterus, and barbiturate overdose [en.wikipedia.org]

[…] palsies(1) Internuclear ophthalmoplegia One and half syndrome Horizontal gaze palsy Monocular elevation deficit Vertical gaze palsy Skew deviation Ocular tilt reaction(2) [medicine.uiowa.edu]

Optokinetic nystagmus(2) 3.Saccades(2) 4.Pursuit(2) 5.Convergence(2) 6.Divergence(2) 7.Specific ocular motor syndromes: Cranial nerve palsies(1) Third, fourth and sixth Supranuclear [medicine.uiowa.edu]

Niemann-Pick Disease Type C1

supranuclear ophthalmoplegia, Niemann-Pick disease type D, Niemann-Pick disease Nova Scotian type Niemann-Pick disease (NPD) is a lipid storage disorder that results from [centogene.com]

[…] disease, subacute juvenile form, Niemann-Pick disease, chronic neuronopathic form, Niemann-Pick disease without sphingomyelinase deficiency, Neurovisceral storage disease with vertical [centogene.com]

Niemann-Pick Disease Type D

Supranuclear Ophthalmoplegia. [xpertdox.com]

supranuclear ophthalmoplegia, maladie de Neville, DAF syndrome, adult dystonic lipidosis, adult neurovisceral lipidosis, giant cell hepatitis, and lactosyl ceramidosis [medlink.com]

supranuclear ophthalmoplegia, Niemann-Pick disease type D, Niemann-Pick disease Nova Scotian type Niemann-Pick disease (NPD) is a lipid storage disorder that results from [centogene.com]

Thoracomelic Dysplasia

SUPRANUCLEAR OPHTHALMOPLEGIA 257100 : NEUTROPENIA, LETHAL CONGENITAL, WITH EOSINOPHILIA 257300 : NONDISJUNCTION 257350 : NUCHAL BLEB, FAMILIAL 257400 : NYSTAGMUS, CONGENITAL [www5.geometry.net]

NEUROPATHY, HEREDITARY SENSORY, ATYPICAL 256870 : NEUROPATHY, PAINFUL 257000 : NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES 257050 : NEUROVISCERAL STORAGE DISEASE WITH VERTICAL [www5.geometry.net]

Neurologic Manifestation of Whipple Disease

Present in 50% of patients Myoclonus - Present in 20% of patients Eye findings in CNS-WD are as follows: Supranuclear ophthalmoplegia Both horizontal and vertical SNO are [emedicine.medscape.com]

Nearly all cases of ophthalmoplegia are supranuclear, usually in the form of vertical volitional ophthalmoplegia with preserved involuntary extraocular movements in response [oncohemakey.com]

Almost always the ophthalmoplegia is of supranuclear gaze palsy type with involvement of vertical rather than horizontal movement. Pure oculomotor palsies are rare. [jnnp.bmj.com]

Niemann-Pick Disease Type C2

supranuclear ophthalmoplegia, Niemann-Pick disease type D, Niemann-Pick disease Nova Scotian type Niemann-Pick disease (NPD) is a lipid storage disorder that results from [centogene.com]

Neuraminidase 1 Deficiency

The clinical features are heterogeneous, although most patients develop progressive neurological manifestations including vertical supranuclear ophthalmoplegia, ataxia, dystonia [glycoforum.gr.jp]

Disorder of Amino Acid Metabolism

Specific neurological signs such as vertical supranuclear ophthalmoplegia or a cherry red spot may suggest a particular metabolic disease. [jnnp.bmj.com]

Spastic Quadriplegic Cerebral Palsy Type 2

supranuclear ophthalmoplegia, dysarthria, and dystonia. [adc.bmj.com]

Ultimately, there is complete loss of vertical eye movements involving both upward and downward gaze, which, occurring on a background of progressive neurological deterioration [adc.bmj.com]

[…] disease type C is an autosomal recessive condition which presents neurologically between the ages of 2 and 12 years, with tremor, clumsiness, ataxia, poor concentration, vertical [adc.bmj.com]

Perinatal Lethal Gaucher Disease

supranuclear ophthalmoplegia Related symptoms: Autosomal recessive inheritance Intellectual disability Seizures Global developmental delay Generalized hypotonia SOURCES: [mendelian.co]

[…] disease, subacute juvenile form, niemann-pick disease, chronic neuronopathic form, niemann-pick disease without sphingomyelinase deficiency, neurovisceral storage disease with vertical [mendelian.co]

Convergence Nystagmus

Vertical supranuclear ophthalmoplegia has also been associated with metabolic disorders, such as Niemann-Pick disease, Wilson's disease, kernicterus, and barbiturate overdose [en.wikipedia.org]

There is almost always an associated supranuclear ophthalmoplegia affecting vertical and later horizontal movements, with initial sparing of vestibulo-ocular reflexes, but [neuroophthalmology.ca]

X-Linked Congenital Nystagmus Type 5

Syndrome of vertical supranuclear ophthalmoplegia. [neuroophthalmology.ca]

Combined horizontal and vertical supranuclear ophthalmoplegia. Tay Sachs disease (hexosaminidase A deficiency). [neuroophthalmology.ca]

Cerebral Palsy with Spastic Diplegia

supranuclear ophthalmoplegia, dysarthria, and dystonia. [adc.bmj.com]

Ultimately, there is complete loss of vertical eye movements involving both upward and downward gaze, which, occurring on a background of progressive neurological deterioration [adc.bmj.com]

Progressive Supranuclear Palsy

supranuclear ophthalmoplegia, pseudobulbar palsy, dysarthria, dystonic rigidity-in-extension of the neck, and mild dementia."3 By the early 1960s six of these patients had [movementdisorders.org]

Introduction In this report we are describing a progressive brain disease featured by supranuclear ophthalmoplegia affecting chiefly vertical gaze, pseudobulbar palsy, dysarthria [doi.org]

Parana Hard-Skin Syndrome

SUPRANUCLEAR OPHTHALMOPLEGIA 257100 : NEUTROPENIA, LETHAL CONGENITAL, WITH EOSINOPHILIA 257300 : NONDISJUNCTION 257350 : NUCHAL BLEB, FAMILIAL 257400 : NYSTAGMUS, CONGENITAL [www5.geometry.net]

Cranial Neuropathy

Some patients undergoing cardiovascular bypass surgery with deep hypothermia emerge with a horizontal and vertical supranuclear ophthalmoplegia that spares vestibulo-ocular [neuroophthalmology.ca]

[…] anti-Hu antibodies can progress over a few months from upgaze paresis with slowed horizontal saccades and gaze-paretic nystagmus, to bilateral ptosis and complete external ophthalmoplegia [neuroophthalmology.ca]

Niemann-Pick Disease

supranuclear ophthalmoplegia, maladie de Neville, DAF syndrome, adult dystonic lipidosis, adult neurovisceral lipidosis, giant cell hepatitis, and lactosyl ceramidosis [medlink.com]

[…] in the 1960s and 1970s under numerous names: juvenile Niemann-Pick disease, juvenile dystonic lipidosis, atypical cerebral lipidosis, neurovisceral storage disease with vertical [medlink.com]

GM2 Gangliosidosis Variant AB

Secondary Parkinsonism

[…] the classic vertical supranuclear ophthalmoplegia of PSP (14). [frontiersin.org]

In VP patients, unilateral mesencephalic reticular formation or bilateral thalamic lesions have been identified as potential causes of vertical nuclear ophthalmoplegia mimicking [frontiersin.org]

Pelviscapular Dysplasia

SUPRANUCLEAR OPHTHALMOPLEGIA 257100 : NEUTROPENIA, LETHAL CONGENITAL, WITH EOSINOPHILIA 257300 : NONDISJUNCTION 257350 : NUCHAL BLEB, FAMILIAL 257400 : NYSTAGMUS, CONGENITAL [www5.geometry.net]

Familial Progressive Vestibulocochlear Dysfunction

ICD10 - G23.1 Disease Progressive supranuclear palsy (PSP) or Steele-Richardson-Olszewski syndrome is characterized by a progressive supranuclear ophthalmoplegia typically [eyewiki.aao.org]

Supranuclear gaze palsy occurs in half of ADCA II, with slow saccades, difficulty initiating both vertical and horizontal saccades and the compensatory use of head thrusts [neuroophthalmology.ca]

Spastic Cerebral Palsy

supranuclear ophthalmoplegia, dysarthria, and dystonia. [adc.bmj.com]

Ultimately, there is complete loss of vertical eye movements involving both upward and downward gaze, which, occurring on a background of progressive neurological deterioration [adc.bmj.com]

Infantile 3-Phosphoglycerate Dehydrogenase Deficiency

Vertical supranuclear ophthalmoplegia occurs in Niemann-Pick disease type C, and saccadic initiation failure and defective optokinetic nystagmus occurs in Gaucher disease [neupsykey.com]

Syndesmodysplasic Dwarfism

SUPRANUCLEAR OPHTHALMOPLEGIA 257100 : NEUTROPENIA, LETHAL CONGENITAL, WITH EOSINOPHILIA 257300 : NONDISJUNCTION 257350 : NUCHAL BLEB, FAMILIAL 257400 : NYSTAGMUS, CONGENITAL [www5.geometry.net]

Pseudobulbar Palsy

J.C....Olszewski J. 1964 49 SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. [malacards.org]

A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. ( 14107684 ) Steele [malacards.org]