We present three patients with a clinical course and cerebrospinal fluid findings consistent with a diagnosis of primary progressive multiple sclerosis (PPMS). Extensive and repeated magnetic resonance imaging (MRI) examinations showed only diffuse abnormality in brain and spinal cord, but no focal lesions. We propose[…] [ncbi.nlm.nih.gov]

In early stages, decreased position and vibratory sensation in the extremities is accompanied by mild to moderate weakness and hyporeflexia. [msdmanuals.com]

Posterior column dysfunction decreases vibratory sensation and proprioception (joint sense). [en.wikipedia.org]

Multifocal motor neuropathy Other names Multifocal motor neuropathy with conduction block Specialty Neurology Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the extremities gradually weaken. The disorder, a pure motor neuropathy syndrome, is sometimes mistaken for[…] [en.wikipedia.org]

Multiple sclerosis (MS, disseminated sclerosis, encephalomyelitis disseminata) is an inflammatory demyelinating disease of the central nervous system. Multiple sclerosis is divided into the following categories: Relapsing-remitting MS, Secondary progressive MS, Primary progressive MS and Progressive-relapsing MS. Individuals[…] [symptoma.com]

sensation Decreased vibration sense Decreased vibratory sense Diminished vibratory sense Impaired vibratory sense [ more ] 0002495 Limb ataxia 0002070 Muscular hypotonia [rarediseases.info.nih.gov]

[…] nystagmus 0000640 Genetic anticipation with paternal anticipation bias 0003744 Hyperreflexia Increased reflexes 0001347 Impaired horizontal smooth pursuit 0001151 Impaired vibratory [rarediseases.info.nih.gov]

[…] tendon reflexes, extensor plantar responses and loss of vibratory and proprioceptive sensation. [karger.com]

At the age of 64 years, neurological examination showed a spastic-ataxic gait worsened by eye closing, dysarthria with slurred speech, mild limb dysmetria, decreased deep [karger.com]

From Wikidata Jump to navigation Jump to search autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has material basis in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene Azorean disease (disorder) MJD spinocerebellar ataxia type 3 spinocerebellar[…] [wikidata.org]

We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord[…] [ncbi.nlm.nih.gov]

In 1994, Ranum and colleagues identified a ten-generation American kindred with a relatively mild autosomal dominant form of spinocerebellar ataxia (Ranum et al., 1994). The mutation was mapped to the centromeric region of chromosome 11, and the disorder designated SCA5 (Ranum et al., 1994). Using a multifaceted[…] [ncbi.nlm.nih.gov]