Primary Progressive Multiple Sclerosis
Spinal neurodegeneration is an important determinant of disability progression in patients with primary progressive multiple sclerosis. Advanced imaging techniques, such as single-voxel (1)H-magnetic resonance spectroscopy and q-space imaging, have increased pathological specificity for neurodegeneration, but are[…][ncbi.nlm.nih.gov]
Pernicious Anemia
Abstract A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with[…][ncbi.nlm.nih.gov]
Subacute Combined Degeneration of Spinal Cord
Posterior column dysfunction decreases vibratory sensation and proprioception (joint sense).[en.wikipedia.org]
Multifocal Motor Neuropathy
Abstract Multifocal Motor Neuropathy (MMN) is a newly described disorder that might mimics the Motor Neuron Disease (MND). MMN is considered by some authors to be an entity distinct from Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), nevertheless because a pure-motor variant of CIDP is well[…][ncbi.nlm.nih.gov]
Multiple Sclerosis
BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear. OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS)[…][ncbi.nlm.nih.gov]
Spinocerebellar Ataxia Type 1
sensation Decreased vibration sense Decreased vibratory sense Diminished vibratory sense Impaired vibratory sense [ more ] 0002495 Limb ataxia 0002070 Muscular hypotonia[rarediseases.info.nih.gov]
[…] nystagmus 0000640 Genetic anticipation with paternal anticipation bias 0003744 Hyperreflexia Increased reflexes 0001347 Impaired horizontal smooth pursuit 0001151 Impaired vibratory[rarediseases.info.nih.gov]
Machado-Joseph Disease
Clin Neurol Neurosurg. 2009 Dec;111(10):791-4. doi: 10.1016/j.clineuro.2009.07.016. Epub 2009 Aug 26. Author information 1 Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. shiroh46@med.kurume-u.ac.jp Abstract We report[…][ncbi.nlm.nih.gov]
Spinal Cord Compression
Objectives To evaluate the feasibility, safety, clinical, and radiologic outcomes of a minimally invasive direct lateral-approach corpectomy (MIDLaC) for decompression and stabilization of symptomatic metastatic spinal cord compression (MSCC). Methods A retrospective study on a prospective cohort was conducted.[…][ncbi.nlm.nih.gov]
Spinocerebellar Ataxia Type 5
Sci Rep. 2016 Feb 17;6:21375. doi: 10.1038/srep21375. Author information 1 Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455. 2 Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455. Abstract Spinocerebellar ataxia type[…][ncbi.nlm.nih.gov]
Hypogammaglobulinemia
OBJECTIVE: The aim of this study was to investigate Legg-Calvé-Perthes disease (PD) pathogenesis by comparing absolute circulating endothelial progenitor cell (EPC) counts, serum levels of vascular endothelial growth factor-A (VEGF-A) and immunoglobulins between PD patients and controls. METHODS: The study[…][ncbi.nlm.nih.gov]