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65 Possible Causes for Villous Blunting

  • Combined Immunodeficiency due to LRBA Deficiency

    LRBA deficiency is a rare genetic disorder of the immune system. This disorder is caused by a mutation in the gene LRBA. LRBA stands for “lipopolysaccharide (LPS)-responsive and beige-like anchor protein”. This condition is characterized by autoimmunity, lymphoproliferation, and immune deficiency. It was first[…][]

  • Autoimmune Enteropathy

    In 5 cases (20%), the duodenum exhibited changes indistinguishable from celiac disease, with villous blunting and intraepithelial lymphocytosis.[] Endoscopically, the duodenum typically exhibits villous blunting with partial or complete villous blunting, deep crypt lymphocytosis, increased apoptotic bodies, and minimal[] The duodenal biopsies showed villous blunting, chronic inflammation, and decreased to absent goblet cells, Paneth cells, and endocrine cells by histology and electron microscopy[]

  • Tropical Sprue

    The ileal mucosa displayed more severe villous blunting with higher Marsh stages than in the corresponding duodenum from 5 patients.[] No case of complete villous blunting (Marsh stage 3c) was identified in tropical sprue , contrasting with 25% in gluten-sensitive enteropathy cases.[] The biopsy will show variable degrees of atrophy of the small intestine with villous blunting and inflammation.[]

  • Collagenous Sprue

    Abstract Collagenous sprue (CS) is a pattern of small-bowel injury characterized histologically by marked villous blunting, intraepithelial lymphocytes, and thickened sub-epithelial[] blunting is a consistent observation.[] (a) Small intestinal mucosa shows villous blunting and increase in intraepithelial lymphocytes and surface epithelial inj demonstrates collagenous sprue-like changes.[]

  • HIV Enteropathy

    As indicated by villous blunting and inflammation on duodenal histology, those with diarrhea and parasites showed the most severe damage.[] blunting and atrophy, crypt hypertrophy, increased intraepithelial lymphocytes, variably increased mononuclear cell in lamina propria.[] […] edematous edges Histologically show granulation tissue with mixed acute and chronic inflammatory infiltrate often with eosinophils AIDS enteropathy HIV enteropathy causes villous[]

  • Isospora Belli

    Other histologic changes include villous blunting, crypt hyperplasia, and mixed inflammatory cell infiltration often associated with many eosinophils .[] The small bowel showed increased eosinophils, plasma cells, and lymphocytes in the lamina propria with some blunting of the villous architecture without increase in intraepithelial[]

  • Enteropathy, Familial with Villous Edema and IgG2 Deficiency

    Villous blunting was graded based on the villous height-to-crypt length ratio. A normal ratio was defined as between 3:1 and 5:1.[] Mild, moderate and severe villous blunting were defined by a villous-to-crypt ratio between 2:1 and 3:1, 1:1 and 2:1, and 8 , 9 When available, immunohistochemical stains[] blunting, prominence of apoptosis, small intestinal villous and crypt architecture, cryptitis and crypt abscesses.[]

  • Intestinal Lymphoid Hyperplasia

    Path showed total villous blunting with atrophy in the second and third portion of the duodenum. The stomach antrum biopsy revealed lymphocytic gastritis without H.[] In small bowel mild villous blunting and atrophy without crypt hyperplasia was seen. The number of intraepithelial lymphocytes was within normal range.[]

  • Common Variable Immunodeficiency

    Duodenal villous blunting with ecchymotic areas.[] blunting in most small intestinal specimens that have increased intraepithelial lymphocytes Variable crypt distortion in 47% of colon specimens Non-caseating granulomas in[] The duodenum exhibited villous blunting, swollen and granular appearance, micronodular pattern, and exuberant ecchymotic areas (Figure 1). Figure 1.[]

  • Intestinal Microsporidiosis

    Histopathological changes consisted of villous atrophy, blunting of mucosa and flattening of individual epithelial cells in the large intestine.[] The small intestinal mucosa may be normal appearing, but typically shows mild villous blunting, focally increased intraepithelial lymphocytes, crypt hyperplasia and some surface[] Histological abnormalities may be absent, but usually there is evidence of an acute enteritis and there may be villous blunting.[]

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