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65 Possible Causes for Villous Blunting

  • Combined Immunodeficiency due to LRBA Deficiency

    LRBA deficiency is a rare genetic disorder of the immune system. This disorder is caused by a mutation in the gene LRBA. LRBA stands for “lipopolysaccharide (LPS)-responsive and beige-like anchor protein”. This condition is characterized by autoimmunity, lymphoproliferation, and immune deficiency. It was first[…][en.wikipedia.org]

  • Autoimmune Enteropathy

    In 5 cases (20%), the duodenum exhibited changes indistinguishable from celiac disease, with villous blunting and intraepithelial lymphocytosis.[ncbi.nlm.nih.gov] Endoscopically, the duodenum typically exhibits villous blunting with partial or complete villous blunting, deep crypt lymphocytosis, increased apoptotic bodies, and minimal[ncbi.nlm.nih.gov] The duodenal biopsies showed villous blunting, chronic inflammation, and decreased to absent goblet cells, Paneth cells, and endocrine cells by histology and electron microscopy[ncbi.nlm.nih.gov]

  • Tropical Sprue

    The ileal mucosa displayed more severe villous blunting with higher Marsh stages than in the corresponding duodenum from 5 patients.[ncbi.nlm.nih.gov] No case of complete villous blunting (Marsh stage 3c) was identified in tropical sprue , contrasting with 25% in gluten-sensitive enteropathy cases.[journals.lww.com] The biopsy will show variable degrees of atrophy of the small intestine with villous blunting and inflammation.[ddc.musc.edu]

  • Collagenous Sprue

    Abstract Collagenous sprue (CS) is a pattern of small-bowel injury characterized histologically by marked villous blunting, intraepithelial lymphocytes, and thickened sub-epithelial[ncbi.nlm.nih.gov] blunting is a consistent observation.[medical-dictionary.thefreedictionary.com] (a) Small intestinal mucosa shows villous blunting and increase in intraepithelial lymphocytes and surface epithelial inj demonstrates collagenous sprue-like changes.[documents.tips]

  • HIV Enteropathy

    As indicated by villous blunting and inflammation on duodenal histology, those with diarrhea and parasites showed the most severe damage.[ajtmh.org] blunting and atrophy, crypt hypertrophy, increased intraepithelial lymphocytes, variably increased mononuclear cell in lamina propria.[pathologyoutlines.com] […] edematous edges Histologically show granulation tissue with mixed acute and chronic inflammatory infiltrate often with eosinophils AIDS enteropathy HIV enteropathy causes villous[pathologyoutlines.com]

  • Isospora Belli

    Other histologic changes include villous blunting, crypt hyperplasia, and mixed inflammatory cell infiltration often associated with many eosinophils .[humpath.com] The small bowel showed increased eosinophils, plasma cells, and lymphocytes in the lamina propria with some blunting of the villous architecture without increase in intraepithelial[ispub.com]

  • Enteropathy, Familial with Villous Edema and IgG2 Deficiency

    Villous blunting was graded based on the villous height-to-crypt length ratio. A normal ratio was defined as between 3:1 and 5:1.[nature.com] Mild, moderate and severe villous blunting were defined by a villous-to-crypt ratio between 2:1 and 3:1, 1:1 and 2:1, and 8 , 9 When available, immunohistochemical stains[nature.com] blunting, prominence of apoptosis, small intestinal villous and crypt architecture, cryptitis and crypt abscesses.[nature.com]

  • Intestinal Lymphoid Hyperplasia

    Path showed total villous blunting with atrophy in the second and third portion of the duodenum. The stomach antrum biopsy revealed lymphocytic gastritis without H.[healio.com] In small bowel mild villous blunting and atrophy without crypt hyperplasia was seen. The number of intraepithelial lymphocytes was within normal range.[ijpmonline.org]

  • Common Variable Immunodeficiency

    Duodenal villous blunting with ecchymotic areas.[acgcasereports.gi.org] blunting in most small intestinal specimens that have increased intraepithelial lymphocytes Variable crypt distortion in 47% of colon specimens Non-caseating granulomas in[surgpathcriteria.stanford.edu] The duodenum exhibited villous blunting, swollen and granular appearance, micronodular pattern, and exuberant ecchymotic areas (Figure 1). Figure 1.[acgcasereports.gi.org]

  • Intestinal Microsporidiosis

    Histopathological changes consisted of villous atrophy, blunting of mucosa and flattening of individual epithelial cells in the large intestine.[folia.paru.cas.cz] The small intestinal mucosa may be normal appearing, but typically shows mild villous blunting, focally increased intraepithelial lymphocytes, crypt hyperplasia and some surface[histopathology-india.net] Histological abnormalities may be absent, but usually there is evidence of an acute enteritis and there may be villous blunting.[nursinglink.monster.com]

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