Possible Causes for viral inclusion body Herpes Labialis bodies (non-specific) Results available within 1 hour Unable to differentiate between HSV-1 and HSV-2 Viral culture: gold standard for definitive diagnosis; results available [amboss.com] Finding specific giant cells with nuclei that carry the virus (inclusion bodies) suggests an HSV infection. [dentalresource.org] with confirmation through the following tests: Light microscopy findings on a Tzanck smear Multinucleated giant cells (non-specific) Eosinophilic intranuclear Cowdry A inclusion [amboss.com] Herpes Simplex Virus Type 1 bodies (non-specific) Results available within 1 hour Unable to differentiate between HSV-1 and HSV-2 Viral culture: gold standard for definitive diagnosis; results available [amboss.com] with confirmation through the following tests: Light microscopy findings on a Tzanck smear Multinucleated giant cells (non-specific) Eosinophilic intranuclear Cowdry A inclusion [amboss.com] Primary Herpes Simplex Infection General Pathology Corneal scrapings of HSV keratitis prepared with Giemsa stain may reveal the presence of intranuclear viral inclusion bodies. [eyewiki.aao.org] By electron microscopy the inclusion body consists of paracrystalline arrays of viral capsids and electron-dense glycoprotein. [histopathology-india.net] bodies (non-specific) Results available within 1 hour Unable to differentiate between HSV-1 and HSV-2 Viral culture: gold standard for definitive diagnosis; results available [amboss.com] Herpes Simplex Infection General Pathology Corneal scrapings of HSV keratitis prepared with Giemsa stain may reveal the presence of intranuclear viral inclusion bodies. [eyewiki.aao.org] By electron microscopy the inclusion body consists of paracrystalline arrays of viral capsids and electron-dense glycoprotein. [histopathology-india.net] bodies (non-specific) Results available within 1 hour Unable to differentiate between HSV-1 and HSV-2 Viral culture: gold standard for definitive diagnosis; results available [amboss.com] Cytomegalovirus Histological examination of the gallbladder wall was positive for multiple viral inclusion bodies. [ncbi.nlm.nih.gov] There was a significant association between the detection of owl's eye inclusion bodies and positive CMV PCR (p 0.001); the median CMV viral load was significantly higher [ncbi.nlm.nih.gov] Owl's eye inclusion bodies are not associated with HHV-6 or HHV-7 infection. polymerase chain reaction inclusion bodies viral load Statistics from Altmetric.com polymerase [doi.org] Cytomegalovirus Colitis During the second week, he underwent sigmoidoscopy for biopsy, which revealed viral inclusions of the Cowdry owl eye inclusion bodies characteristic of CMV. [ncbi.nlm.nih.gov] Light microscopy of selected viral diseases (morphology of viral inclusion bodies). Pathol Annu 1976;11:53-75. [ PUBMED ] 34. Schwartz DA, Wilcox CM. [jdeonline.in] Replication in the host cell typically manifests pathologically with large intranuclear inclusion bodies and smaller cytoplasmic inclusions, and is accompanied by the presence [emedicine.medscape.com] Cytomegalovirus Esophagitis Light microscopy of selected viral diseases (morphology of viral inclusion bodies). Pathol Annu 1976;11:53-75. [ PUBMED ] 34. Schwartz DA, Wilcox CM. [jdeonline.in] “Owl’s eye” appearance of nuclear inclusion bodies within infected endothelial cells. Reproduced from Boldogh I, Patel JA, Tyring SK, Chonmaitree T. Cytomegalovirus. [dermatologyadvisor.com] Mucocutaneous manifestations of viral diseases (2nd edition). United Kingdom: Informa; 2010. pp 145-164, with permission. [dermatologyadvisor.com] Herpes Simplex Esophagitis Diagnosis of herpes simplex esophagitis (HSE) was established through histological analysis showing squamous epithelial cells with viral-inclusion-bodies, immunohistochemically [acgcasereports.gi.org] inclusion bodies consistent with herpetic infection were present 68.4% of the time [3]. [ncbi.nlm.nih.gov] By electron microscopy the inclusion body consists of paracrystalline arrays of viral capsids and electron-dense glycoprotein. [histopathology-india.net] Inclusion Body Myositis The current status of treatment for inclusion-body myositis. Neurology. 2006;66:S30-S32. Dalakas MC. Inflammatory, immune, and viral aspects of inclusion-body myositis. [rarediseases.org] viral infection Symptoms of Inclusion Body Myositis There are several Inclusion Body Myositis symptoms that authorize the presence of this disease. [naturalherbsclinic.com] Inclusion-body myositis. Clinical, diagnostic, and pathologic aspects. Neurology. 2006;66:S20-S29. Griggs RC. [rarediseases.org] Hepatitis B Tenofovir disoproxil fumarate (TDF) is a potent nucleotide analogue that is recommended as first-line therapy for patients with chronic hepatitis B. The results of a longitudinal study of TDF treatment demonstrated no development of resistance. We observed one treatment-naïve chronic hepatitis B (CHB) patient[…] [ncbi.nlm.nih.gov] Cytomegalovirus Retinitis Cytomegalovirus (CMV) retinitis rarely occurs in patients with connective tissue disease. We present a rare case of CMV retinitis in a patient with dermatomyositis. A 38-year-old man was admitted due to blurred vision and floaters of right eye. He had been diagnosed with dermatomyositis and taken prednisolone and[…] [ncbi.nlm.nih.gov] Measles MeV causes immunosuppression, and severe sequelae of measles include pneumonia, gastroenteritis, blindness, measles inclusion body encephalitis and subacute sclerosing panencephalitis [ncbi.nlm.nih.gov] Case confirmation depends on clinical presentation and results of laboratory tests, including the detection of anti-MeV IgM antibodies and/or viral RNA. [ncbi.nlm.nih.gov] Brandt Syndrome From Wikidata Jump to navigation Jump to search Human disease Acrodermatitis enteropathica, zinc deficiency type Acrodermatitis enteropathica zinc deficiency type Inherited zinc deficiency Danbolt-Cross syndrome ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE; AEZ Brandt syndrome AE ACRODERMATITIS[…] [wikidata.org] Cytomegalovirus Pneumonia Some of the alveolar spaces were lined by large cells containing homogenous dark purple viral inclusion bodies, surrounded by a characteristic halo, suggestive of CMV infection [ijpmonline.org] The pathologic hallmark of CMV infection is an enlarged cell with viral inclusion bodies. [emedicine.medscape.com] Conventional BAL Cytology Nuclear and cytoplasmic inclusion bodies in conventional BAL cytology are the hallmark of CMV disease. [ispub.com] Genital Herpes in Women What is genital herpes? Genital herpes is a common infection caused by the herpes simplex virus, or HSV. It causes painful blisters that break open and form sores. There are 2 types of HSV. HSV-1 usually infects the lips and mouth. HSV-2 usually infects the genital area. However, you can have infections by either[…] [summitmedicalgroup.com] Cytomegalovirus Mononucleosis Cytomegalic cells and viral inclusion bodies are usually absent. [meddean.luc.edu] bodies is an easy technique, but viral inclusion bodies are not always demonstrable. [41] Location and morphology of cytomegalovirus infected cells In the esophageal biopsy [caijournal.com] “Owl’s eye” appearance of nuclear inclusion bodies within infected endothelial cells. Reproduced from Boldogh I, Patel JA, Tyring SK, Chonmaitree T. Cytomegalovirus. [dermatologyadvisor.com] Subacute Sclerosing Panencephalitis A brain biopsy is indicated only when CSF serology is negative or equivocal in a suspected case to assess the presence of inclusion bodies, measles virus antigens, or viral [ncbi.nlm.nih.gov] body encephalitis (MIBE), and subacute sclerosing panencephalitis (SSPE). [ncbi.nlm.nih.gov] Another Cowdry type-B inclusion bodies, small and multiple, are almost always present in the brainstem. [doi.org] Marburg Virus Disease Marburg virus belongs to the genus Marburgvirus in the family Filoviridae and causes a severe hemorrhagic fever, known as Marburg hemorrhagic fever (MHF), in both humans and nonhuman primates. Similar to the more widely known Ebola hemorrhagic fever, MHF is characterized by systemic viral replication,[…] [ncbi.nlm.nih.gov] Generalized Herpes Simplex Infection of the Newborn By electron microscopy the inclusion body consists of paracrystalline arrays of viral capsids and electron-dense glycoprotein. [histopathology-india.net] The diagnosis of generalized viral infection was established from virologic studies of liver and brain tissue and from the demonstration of intranuclear inclusion bodies in [onlinelibrary.wiley.com] The intranuclear inclusion is the characteristic cellular lesion, and it consists of a single, eosinophilic, well-demarcated inclusion body surrounded by a halo and marginated [histopathology-india.net] Ebola Virus Disease Several macrophages contained big acidophilic inclusion bodies. Inclusion bodies were compatible with viral inclusions. [doi.org] Congenital Cytomegalovirus Infection Cytomegalovirus (CMV) is the most common cause of congenital infection in humans. Some congenitally infected infants will develop sequelae later in life, especially sensorineural hearing loss (SNHL) and mental retardation. There is no generally accepted antiviral therapy for the treatment of symptomatic congenital CMV[…] [ncbi.nlm.nih.gov] Rabies inclusion bodies. [ncbi.nlm.nih.gov] Laboratory Investigation In all three patients, histopathologic examination of central nervous system (CNS) tissues at CDC revealed an encephalitis with viral inclusions suggestive [cdc.gov] Panel A shows multiple intracytoplasmic viral inclusions (Negri bodies, arrows) in neurons in the CNS of Patient 4, who received a kidney from the rabies-infected donor. [doi.org] Chlamydial Conjunctivitis Diagnosing adult inclusion and neonatal conjunctivitis can be challenging. They are sexually transmitted diseases that can easily be managed without any serious ocular or systemic sequelae if recognized and treated early on. A proper differential diagnosis and careful examination is essential in the management of[…] [ncbi.nlm.nih.gov] Yellow Fever The first case of yellow fever in French Guiana since 1902 was reported in March 1998. The yellow fever virus genome was detected in postmortem liver biopsies by seminested polymerase chain reaction. Sequence analysis showed that this strain was most closely related to strains from Brazil and Ecuador. [ncbi.nlm.nih.gov] Smallpox Guarnieri's bodies are composed of viral particles and proteins; each body is the locus of viral replication and assembly. [web.archive.org] The B-type inclusions, also known as Guarnieri bodies, were the sites of viral replication. They were found in virtually all poxvirus infections. [ncbi.nlm.nih.gov] Microscopically, poxviruses produce characteristic cytoplasmic inclusions, the most important of which are known as Guarnieri bodies, and are the sites of viral replication [en.wikipedia.org] Adenovirus Infection A renal transplant biopsy specimen showed granulomatous interstitial nephritis, tubular necrosis, and ground glass-like intranuclear viral inclusion bodies in tubular cells [ncbi.nlm.nih.gov] Urinary cytological examination showed viral inclusion-bearing epithelial cells. [ncbi.nlm.nih.gov] A reduction in baseline immunosuppressive therapy resulted in rapid normalization of allograft function and ultimately viral clearance. [ncbi.nlm.nih.gov] Sexually Transmitted Disease The vesicular fluid has many infectious virus particles and degenerating cells containing eosinophilic intranuclear inclusion bodies and multinucleated giant cells. [atsu.edu] Viral replication induces an erythematous papule that swells into a fluid-filled vesicle. [atsu.edu] Stomatitis bodies in case of herpetiform ulcers and similarity of RAU to viral ulcerative diseases in animals.[ 19 ] Virtanen et al .[ 17 ] in 1995 demonstrated the presence of human [ncbi.nlm.nih.gov] There have been several suggestive, but as yet there exists inconclusive evidence toward a viral etiology. [ncbi.nlm.nih.gov] […] of aphthous ulcers which are indicative of infectious etiology include recurrent ulceration, lymphocytic infiltration, perivascular cuffing, presence of auto-antibodies, inclusion [ncbi.nlm.nih.gov] Desquamative Interstitial Pneumonia It is postulated that the inclusion bodies are not specific for desquamative interstitial pneumonia and do not represent viral particles. [annals.org] In 4 of 12 control cases there were intranuclear inclusion bodies similar to those found in desquamative interstitial pneumonia. [annals.org] Pyoureter […] serous cyst adenoma of ovary 6/Aschoff body..........rheumatic myocrditis 7/Viral inclusion body.........viral pneumonia 8/Asbestos body......asbestos 9/Mickaeil-gottman body [1aim.net] […] of thyroid & serous cyst adenoma of ovary 6/Aschoff body..........rheumatic myocrditis 7/Viral inclusion body.........viral pneumonia 8/Asbestos body......asbestos 9/Mickaeil-gottman [shamsology.mygoo.org] […] rhinoscleroma 3/Schauumann body.......sarcoidosis 4/Asteroid body..........sarcoidosis 5/Psammoma body.............meningioma & papiilary carcinoma of thyroid & [1aim.net]
