Virilization: Causes & Reasons

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Possible Causes for Virilization

Polycystic Ovary Syndrome

[…] grade of virilization. [ncbi.nlm.nih.gov]

[…] genitalia, although behavioural and ovulatory dysfunction can coexist without virilized genitalia based upon the timing of androgen excess. [ncbi.nlm.nih.gov]

Diagnosis is by pregnancy testing, hormone measurement, and imaging to exclude a virilizing tumor. Treatment is symptomatic. [msdmanuals.com]

Adrenogenital Syndrome

21-hydroxylase deficiency in a newborn and a case of virilizing adrenal tumor in a four and half years old female child. [ncbi.nlm.nih.gov]

Persistent virilization and high testosterone levels led to right oophorectomy and completion left oophorectomy 6 months later. [ncbi.nlm.nih.gov]

The three basic clinical types are: (1) simple virilism, (2) virilism and adrenal insufficiency, and (3) virilism and hypertension. [ajronline.org]

Hilar Cell Tumor of the Ovary

Pre-operative retrograde venous catheterization and sampling were used to localize this virilizing tumor. [ncbi.nlm.nih.gov]

Virilization secondary to an ovarian Leydig cell tumor. Management. [nature.com]

Summary A case of virilizing ovarian hilus cell tumor (Leydig-cell tumor) in a 37 year old female was studied by light and electron microscopy. [link.springer.com]

Epithelial Ovarian Cancer

A common symptom is known as virilism, which can include: infrequent menstrual periods menstrual periods after menopause appearance of facial hair a hoarse voice [ovariancanada.org]

Consequently, depending on the specific histology produced, these tumours can cause virilization in women and feminization in men. [en.wikipedia.org]

Neoplasm of the Ovary

Achard- Thiers syndrome 0 *Virilism *Ovarian Neoplasms *Diabetes Complications. TCEAL7 protein, human 0 *Nuclear Proteins Ovarian Neoplasms. [reference.md]

Sex cord-stromal tumor, including estrogen -producing granulosa cell tumor and virilizing Sertoli-Leydig cell tumor or arrhenoblastoma, accounts for 8% of ovarian cancers. [en.wikipedia.org]

Hirsutism, virilism and apparent virilism and their gonadal relationship. II. [sjmms.net]

Androblastoma

We concluded that androblastomas, in spite of their low incidence, are a possibility that should always be considered in women of all ages presenting with signs of virilization [ncbi.nlm.nih.gov]

@article{WarenikSzymankiewicz2012BilateralA, title {Bilateral androblastoma (Sertoli-stromal cell tumor) of the ovary: a rare cause of virilization in a teenager.}, author [semanticscholar.org]

A case of androblastoma with not only signs of virilization but also manifestations of precocious puberty occurring in a five-year-old girl is presented. [ncbi.nlm.nih.gov]

Lipid Cell Tumor of the Ovary

Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. [ncbi.nlm.nih.gov]

Abstract Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. [ncbi.nlm.nih.gov]

Removal of the tumor completely reversed the virilization and the abnormal responses to ACTH and human chorionic gonadotropin. [ncbi.nlm.nih.gov]

Ovarian Androblastoma

The steroid profile of a virilizing ovarian tumor. Obstet. Gynecol. 52 : 73, 1978. PubMed Google Scholar 7. [link.springer.com]

These data suggest that 1) androgens from the androblastoma are responsible for virilization despite aromatizing enzyme activities within normal limits, and 2) both the delta [ncbi.nlm.nih.gov]

Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. [link.springer.com]

Adrenocortical Carcinoma

Report virilizing oncocytic adrenocortical carcinoma in a 50-year-old woman. [ncbi.nlm.nih.gov]

During follow-up, she gradually developed Cushingoid features and virilization. [ncbi.nlm.nih.gov]

A dramatic regression of virilization features occurred after adrenalectomy. [ncbi.nlm.nih.gov]

Achard Thiers Syndrome

- Adrenogenital disorders (& [feminisation] or [virilisation] or [Achard-Thiers syndrome]) (disorder) - Adrenogenital disorders (& [feminization] or [virilization] or [Achard-Thiers [snomedbrowser.com]

Achard-Thiers syndrome One form of a virilizing disorder of adrenocortical origin in women, characterised by masculinization and menstrual disorders in association with manifestations [encyclo.co.uk]

Achard-Thiers syndrome - one form of a virilizing disorder of adrenocortical origin in women. Thiers, Joseph, French physician, 1885–. [medical-dictionary.thefreedictionary.com]

Gynandroblastoma

The hormonal data obtained do not account for the marked virilization observed. [ncbi.nlm.nih.gov]

[…] ovarian tumor Virilizing ovarian tumor (disorder) ICD 10 CM 2017, (Clinical Modification) for coding of death certificates and mortality data. [averbis.com]

Gynandroblastoma usually presents clinically as an abdominal mass, often associated with either virilizing or feminizing manifestations. [ncbi.nlm.nih.gov]

Ovarian Dysgerminoma

Certain subtypes may occasionally be associated with isosexual precocity, dysgenetic gonads, virilization, hyperthyroidism or carcinoid syndrome (see this term). [orpha.net]

These cells are known for their hormonal function which may lead to virilization or feminization of the opposite sex. [lecturio.com]

[…] producing : granulosa cell tumor and theca cell tumor Androgen producing: Sertoli-Leydig cell tumor Occurs very rarely; 20% malignant transformation Production of androgens virilization [amboss.com]

Placental Aromatase Deficiency

The mothers usually show the onset of progressive virilization during the third trimester. The male fetus has normal genitalia. See also disorders of sexual development [humpath.com]

Hirsutism Defined as excessive growth of androgen-responsive terminal hair in women excess hair growth in areas where hair growth is normally minimal Virilization Defined [medbullets.com]

Placental aromatase deficiency, which was characterized by maternal and fetal virilization and by a low level of estrogen excretion into urine during pregnancy, was studied [ncbi.nlm.nih.gov]

Central Precocious Puberty

Abstract We present a 6-year-old boy with a virilizing adrenocortical tumor who initially presented with peripheral precocious puberty. [ncbi.nlm.nih.gov]

During therapy, we observed a decline in the level of free testosterone (Table 1) with an arrest of further virilization. [cyberleninka.org]

During therapy, we observed a decline in the level of free testosterone (Table 1 ) with an arrest of further virilization. [jmedicalcasereports.biomedcentral.com]

Adrenal Cortical Adenoma

We recently experienced a 17-year-old pubertal girl who showed signs of virilization and a high serum level of testosterone. [ncbi.nlm.nih.gov]

A virilizing, gonadotrophin-responsive adrenal cortical adenoma was removed from a 54-year-old woman. [ncbi.nlm.nih.gov]

An ectopic adrenal cortical adenoma containing high levels of androstenedione but without clinically detectable virilizing effects was found in the spinal intradural space [ncbi.nlm.nih.gov]

Hypogonadism

These would allow optimal virilization and normal sexual function.  In late teenage male patients with delayed puberty, testicular size should be monitored for evidence of [slideshare.net]

[…] their length and width may be measured Examination of the genitalia for hypospadias Examination of the scrotum to see if it is completely fused Evaluation of the extent of virilization [emedicine.medscape.com]

[…] treatment with testosterone does not interfere with later therapy to induce fertility, most male patients with hypogonadotropic hypogonadism prefer to initiate and maintain virilization [emedicine.medscape.com]

Leydig Cell Tumor of the Testis

A normally-virilized 24-year-old white man who had gynecomastia was found to have a Leydig-cell tumor of the testis, without demonstrable metastases. [ncbi.nlm.nih.gov]

LCTs of the testis are frequently hormonally active, leading to either feminizing or virilizing syndromes. The tumor is usually benign, but malignant variants can occur. [ncbi.nlm.nih.gov]

Virilization (including precocious puberty) may occur. Hyperestrogenism may also occur and patients may demonstrate gynaecomastia. [radiopaedia.org]

Benign Ovarian Neoplasm

The female fetus had no signs of virilization. In mother all symptoms and effusions resolved. [ncbi.nlm.nih.gov]

Six patients, two of whom were virilized, were pregnant. Four tumors appeared malignant on histologic examination. [scienceopen.com]

virilization. [ijem.in]

Acquired Adrenogenital Syndrome

255.2 Hyperplasia, hyperplastic adrenal (capsule) (cortex) (gland) 255.8 with sexual precocity (male) 255.2 virilism, adrenal 255.2 virilization (female) 255.2 congenital [healthprovidersdata.com]

congenital Adrenal hyperplasia, congenital, simple virilizing Adrenal hyperplasia, congenital, virilizing, non salt Adrenogenital disorder Congenital adrenal hyperplasia [icd9data.com]

Adrenal virilism is rare and affects females twice as often as males. [family-health-information.com]

Leydig Cell Tumor

Virilization secondary to an ovarian Leydig cell tumor. [ncbi.nlm.nih.gov]

Virilization in childhood results from an adrenal and/or ovarian disorder. [ncbi.nlm.nih.gov]

Virilization is caused by less than 0.5% of all ovarian tumors. Here we report a case of virilizing Leydig cell tumor of the left ovary in a 36 year old woman. [ncbi.nlm.nih.gov]

Adrenal Gland Neoplasm

[…] remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization [icd.codes]

Adrenal virilism is confirmed by the finding of an excess of serum androstenedione and dehydroepiandrosterone. [en.wikipedia.org]

Adrenocortical Hyperfunction: • Cushing Syndrome (ZF) • Hyperaldosteronism (ZG) • Virilizing syndromes (ZR) 2. [slideshare.net]

Sertoli Leydig Cell Tumor

After tumor ablation, a regular menstrual cycle followed and progressive reduction of virilism was noted. [ncbi.nlm.nih.gov]

A 21-year-old white woman presented with virilization, hirsutism, and acne of 1.5 years' duration. [ncbi.nlm.nih.gov]

Five patients presented with feminization, two with accompanying virilization. One presented with amenorrhea alone. [ncbi.nlm.nih.gov]

X-Linked Hypogonadotropic Hypogonadism without Anosmia

Virilization and feminization according to age alleviate the psychological burden and allow for the development of age-appropriate sexual behavior. [symptoma.com]

Thecoma

The patient did not have regression of virilism soon. [ncbi.nlm.nih.gov]

Although laser treatment helped with her hirsutism, her other virilizing symptoms (deepening of voice, clitoromegaly) did not improve postoperatively. [ncbi.nlm.nih.gov]

Surgery is the primary treatment of virilizing thecoma. [eymj.org]

Granulosa Cell Tumor

Virilization has persisted for 8 years after surgery. Adult-type GC tumor is an extremely rare cause of virilization. [ncbi.nlm.nih.gov]

We report a case of a GCT presenting with virilization and initially characterized on 3-dimensional (3-D) ultrasound. [ncbi.nlm.nih.gov]

Our patient had primary amenorrhea with virilization that developed gradually over a period of three years. [ijem.in]

Virilization

[…] hypertestosteronemia and virilization. [ncbi.nlm.nih.gov]

Postmenopausal virilization may be associated with adrenal or ovarian androgen-secreting tumors or with benign conditions. [ncbi.nlm.nih.gov]

0 references Encyclopædia Britannica Online ID science/virilization 0 references Sitelinks Wikipedia (14 entries) edit arwiki تذكير dewiki Virilisierung enwiki Virilization [wikidata.org]

Classic Congenital Adrenal Hyperplasia

High levels of androgens in women may cause virilization of the larynx and a masculine voice. [ncbi.nlm.nih.gov]

Virilization of female infants [ edit ] Virilization of genetically female (XX) infants usually produces obvious genital ambiguity. [en.wikipedia.org]

Affected females experience virilization both physically and psychologically. Steroid 21-OHD can be diagnosed in utero through molecular genetic analysis of fetal DNA. [ncbi.nlm.nih.gov]

Kallmann Syndrome Type 3

The choice for particular hormone replacement therapy protocol aimed at virilizing the patient will depend on age at diagnosis and local practices [ 4 ]. [omicsonline.org]

All 15 men had received previous hormonal therapy to induce virilization, fertility, or both. [f1000.com]

Alcohol-induced pseudo-Cushing's syndrome E24.8 Other Cushing's syndrome E24.9 Cushing's syndrome, unspecified E25 Adrenogenital disorders Includes: adrenogenital syndromes, virilizing [apps.who.int]

Launois Syndrome

We report the first description of a Launois-Bensaude syndrome involving the orbit. Launois-Bensaude syndrome was diagnosed in a 70-year-old-man who presented with severe bilateral proptosis (Hertel value 26mm). We performed a bilateral transpalpebral orbital decompression by resection of intraorbital fat without[…] [ncbi.nlm.nih.gov]

Ovarian Cyst

Case 1 demonstrates the ovarian origin of this transient virilization. [ncbi.nlm.nih.gov]

This leads to an ovarian hyperandrogenaemia which disrupts the menstrual cycle and has the effect of virilization. [flexikon.doccheck.com]

Maternal virilization can occur in up to 30% of cases, with a 50% risk of virilization of the female fetus; male fetuses are unaffected. [web.archive.org]