Virilization: Causes & Reasons

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Possible Causes for Virilization

Adrenogenital Syndrome

Persistent virilization and high testosterone levels led to right oophorectomy and completion left oophorectomy 6 months later. [ncbi.nlm.nih.gov]

Clinically, the children may present in two forms: “simple virilization” or “salt wasting.” [accessanesthesiology.mhmedical.com]

At the age of 35 years, she developed abrupt aggravation of her virilizing symptoms and underwent an adrenalectomy and partial left oophorectomy. [ncbi.nlm.nih.gov]

Hilar Cell Tumor of the Ovary

Synopsis virilization (virilizing ovarian Leydig cell tumor) hyperandrogenism Cushing syndrome ( 18463044 ) Variants bilateral ovarian Leydig cell tumor See also Leydig cell [humpath.com]

Aiman J (1991) Virilizing ovarian tumors. ClinObstetGynecol 34: 835-847. [omicsonline.org]

Adrenal tumors causing virilization are very rare. [edmcasereports.com]

Polycystic Ovary Syndrome

[…] grade of virilization. [ncbi.nlm.nih.gov]

[…] genitalia, although behavioural and ovulatory dysfunction can coexist without virilized genitalia based upon the timing of androgen excess. [ncbi.nlm.nih.gov]

Virilization, isosexual Clinical Information A complex disorder characterized by infertility, hirsutism; obesity; and various menstrual disturbances such as oligomenorrhea [icd9data.com]

Ovarian Androblastoma

The steroid profile of a virilizing ovarian tumor. Obstet. Gynecol. 52 : 73, 1978. PubMed Google Scholar 7. [link.springer.com]

Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. [finto.fi]

Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. [link.springer.com]

Adrenocortical Carcinoma

A dramatic regression of virilization features occurred after adrenalectomy. [ncbi.nlm.nih.gov]

Report virilizing oncocytic adrenocortical carcinoma in a 50-year-old woman. [ncbi.nlm.nih.gov]

We believe that the risk-benefit ratio favors abdominal ultrasound to rule out malignancy in all children presenting with virilization. [ncbi.nlm.nih.gov]

Achard Thiers Syndrome

- Adrenogenital disorders (& [feminisation] or [virilisation] or [Achard-Thiers syndrome]) (disorder) - Adrenogenital disorders (& [feminization] or [virilization] or [Achard-Thiers [snomedbrowser.com]

congenital Adrenal hyperplasia, congenital, simple virilizing Adrenal hyperplasia, congenital, virilizing, non salt Adrenogenital disorder Congenital adrenal hyperplasia [icd9data.com]

Achard-Thiers syndrome One form of a virilizing disorder of adrenocortical origin in women, characterised by masculinization and menstrual disorders in association with manifestations [encyclo.co.uk]

Acquired Adrenogenital Syndrome

255.2 Hyperplasia, hyperplastic adrenal (capsule) (cortex) (gland) 255.8 with sexual precocity (male) 255.2 virilism, adrenal 255.2 virilization (female) 255.2 congenital [healthprovidersdata.com]

congenital Adrenal hyperplasia, congenital, simple virilizing Adrenal hyperplasia, congenital, virilizing, non salt Adrenogenital disorder Congenital adrenal hyperplasia [icd9data.com]

Adrenal virilism is rare and affects females twice as often as males. [family-health-information.com]

Neoplasm of the Ovary

Achard- Thiers syndrome 0 *Virilism *Ovarian Neoplasms *Diabetes Complications. TCEAL7 protein, human 0 *Nuclear Proteins Ovarian Neoplasms. [reference.md]

Sex cord-stromal tumor, including estrogen -producing granulosa cell tumor and virilizing Sertoli-Leydig cell tumor or arrhenoblastoma, accounts for 8% of ovarian cancers. [en.wikipedia.org]

Hirsutism, virilism and apparent virilism and their gonadal relationship. II. [sjmms.net]

Androgen Therapy

Each of the subjects had male-gender behavior but incomplete virilization. [ncbi.nlm.nih.gov]

All had received long-term androgen therapy in fully virilizing doses, and two also received interval androgen therapy. [ncbi.nlm.nih.gov]

The subject who did not respond with clinical virilization nevertheless showed nitrogen retention in response to acute testosterone administration. [ncbi.nlm.nih.gov]

Anabolic Steroid

In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high risk of virilization despite the favourable myotrophic-androgenic [ncbi.nlm.nih.gov]

Oxandrolone does not virilize women in low to moderate doses and it has been used in children also. [thebody.com]

Adverse effects have been documented and include virilization, feminization, adverse lipid profile, psychiatric disorders, cardiac and liver disease. [ncbi.nlm.nih.gov]

Ovarian Dysgerminoma

Certain subtypes may occasionally be associated with isosexual precocity, dysgenetic gonads, virilization, hyperthyroidism or carcinoid syndrome (see this term). [orpha.net]

[…] producing : granulosa cell tumor and theca cell tumor Androgen producing: Sertoli-Leydig cell tumor Occurs very rarely; ∼ 20% malignant transformation Production of androgens → virilization [amboss.com]

These cells are known for their hormonal function which may lead to virilization or feminization of the opposite sex. [lecturio.com]

Epithelial Ovarian Cancer

A common symptom is known as virilism, which can include: infrequent menstrual periods menstrual periods after menopause appearance of facial hair a hoarse voice [ovariancanada.org]

Consequently, depending on the specific histology produced, these tumours can cause virilization in women and feminization in men. [en.wikipedia.org]

Androblastoma

Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. [connects.catalyst.harvard.edu]

This may cause virilization (the appearance of male physical characteristics in females). [dictionary.university]

Lipid Cell Tumor of the Ovary

Removal of the tumor completely reversed the virilization and the abnormal responses to ACTH and human chorionic gonadotropin. [ncbi.nlm.nih.gov]

Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. [ncbi.nlm.nih.gov]

Abstract Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. [ncbi.nlm.nih.gov]

Benign Ovarian Neoplasm

The female fetus had no signs of virilization. In mother all symptoms and effusions resolved. [ncbi.nlm.nih.gov]

[…] and virilization. [ijem.in]

[…] manifestations. 61 Lee MH...Hoh JK 19259367 2009 40 Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. [malacards.org]

Gynandroblastoma

The hormonal data obtained do not account for the marked virilization observed. [ncbi.nlm.nih.gov]

[…] ovarian tumor|Virilizing ovarian tumor (disorder) ICD 10 CM 2017, (Clinical Modification) for coding of death certificates and mortality data. [averbis.com]

Gynandroblastoma usually presents clinically as an abdominal mass, often associated with either virilizing or feminizing manifestations. [ncbi.nlm.nih.gov]

Leydig Cell Tumor of the Testis

LCTs of the testis are frequently hormonally active, leading to either feminizing or virilizing syndromes. The tumor is usually benign, but malignant variants can occur. [ncbi.nlm.nih.gov]

A normally-virilized 24-year-old white man who had gynecomastia was found to have a Leydig-cell tumor of the testis, without demonstrable metastases. [ncbi.nlm.nih.gov]

Virilization (including precocious puberty) may occur. Hyperestrogenism may also occur and patients may demonstrate gynaecomastia. [radiopaedia.org]

Central Precocious Puberty

During therapy, we observed a decline in the level of free testosterone (Table 1) with an arrest of further virilization. [cyberleninka.org]

During therapy, we observed a decline in the level of free testosterone (Table 1 ) with an arrest of further virilization. [jmedicalcasereports.biomedcentral.com]

BACKGROUND: Pediatric adrenocortical tumors are rare but significant causes of virilization and peripheral precocious puberty (PPP). [ncbi.nlm.nih.gov]

Congenital Isolated ACTH Deficiency

Vomiting Hyponatremia Hyperkalemia P450 oxidoreductase deficiency Severe virilization in females, severe under virilization in males No mineralocorticoid deficiency Craniofacial [arupconsult.com]

Classic 21-hydroxylase deficiency can be divided into 2 forms: Salt wasting Simple virilizing In both forms, adrenal androgen levels are elevated, causing virilization. [msdmanuals.com]

Typical findings of CAH Females with the salt wasting and simple virilizing forms of classical CAH present with ambiguous genitalia or virilization of a female genitalia in [clinicaladvisor.com]

X-Linked Hypogonadotropic Hypogonadism without Anosmia

Virilization and feminization according to age alleviate the psychological burden and allow for the development of age-appropriate sexual behavior. [symptoma.com]

Kallmann Syndrome Type 3

All 15 men had received previous hormonal therapy to induce virilization, fertility, or both. [f1000.com]

Alcohol-induced pseudo-Cushing's syndrome E24.8 Other Cushing's syndrome E24.9 Cushing's syndrome, unspecified E25 Adrenogenital disorders Includes: adrenogenital syndromes, virilizing [apps.who.int]

The choice for particular hormone replacement therapy protocol aimed at virilizing the patient will depend on age at diagnosis and local practices [ 4 ]. [omicsonline.org]

Adrenal Cortical Adenoma

Patients with virilization or feminization should be tested for androgens and estrogens respectively. [symptoma.com]

We recently experienced a 17-year-old pubertal girl who showed signs of virilization and a high serum level of testosterone. [ncbi.nlm.nih.gov]

A virilizing, gonadotrophin-responsive adrenal cortical adenoma was removed from a 54-year-old woman. [ncbi.nlm.nih.gov]

Placental Aromatase Deficiency

The mothers usually show the onset of progressive virilization during the third trimester. The male fetus has normal genitalia. See also disorders of sexual development [humpath.com]

A 24-yr-old primigravida showed progressive virilization during the third trimester. [ncbi.nlm.nih.gov]

Placental aromatase deficiency, which was characterized by maternal and fetal virilization and by a low level of estrogen excretion into urine during pregnancy, was studied [ncbi.nlm.nih.gov]

Adrenal Gland Neoplasm

Adrenal virilism is confirmed by the finding of an excess of serum androstenedione and dehydroepiandrosterone. [en.wikipedia.org]

Adrenocortical Hyperfunction: • Cushing Syndrome (ZF) • Hyperaldosteronism (ZG) • Virilizing syndromes (ZR) 2. [slideshare.net]

[…] remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization [icd.codes]

Hypogonadotropic Hypogonadism Type 18

[…] fertility rather than maximize adult height. promote more virilization than occur spontaneouspuberty. control menwere50normalvolunteers [age,21.5 2.3 (SD) yr; range, 19-291who [factpub.org]

The degree of virilization is commensurate with the residual steroidogenic activity of the gonads. [frontiersin.org]

Hawrami, and Mahde Assafi pp. 290–293 https://doi.org/10.5144/0256-4947.2013.290 Abstract Full text PDF Abstract case report Heterosexual precocity: rare manifestation of virilizing [annsaudimed.net]

Ovarian Adenoma

We present a case of virilization due to a Leydig cell adenoma, a rare ovarian tumor representing 0.1% of ovarian tumors. [elsevier.es]

arising from the ovarian stroma, mimicking to a greater or lesser extent derivatives of the sex cord mesenchyme of the testis, and sometimes causing defeminization and virilization [kmle.co.kr]

Leydig Cell Tumor

More than 75% of patients show signs of virilization due to overproduction of testosterone. [ncbi.nlm.nih.gov]

Virilization in childhood results from an adrenal and/or ovarian disorder. [ncbi.nlm.nih.gov]

Virilization secondary to an ovarian Leydig cell tumor. [ncbi.nlm.nih.gov]

Anorchia

In fact they should be suspected for virilized congenital hyperplasia. [ijem.in]

Androgen replacement therapy induces pubertal virilization (changes that make a male body different from a female body) and maintains in adult life. [fertilitypedia.org]

Several conditions may mimic congenital anorchia, the most common being virilization of a female fetus as a result of congenital adrenal hyperplasia, meternal androgen ingestion [onlinelibrary.wiley.com]

Thecoma

Keywords Thecoma, pregnancy, hirsutism, Virilism About this article Keywords Thecoma pregnancy hirsutism Virilism Authors Małgorzata Kogut Jarosław Janeczko Małgorzata Trzcińska [journals.viamedica.pl]

Although laser treatment helped with her hirsutism, her other virilizing symptoms (deepening of voice, clitoromegaly) did not improve postoperatively. [ncbi.nlm.nih.gov]

virilizing tumor at her left ovary. [synapse.koreamed.org]

Gonadoblastoma

The four patients with Y chromosome material had non-virilized female genitalia. [ncbi.nlm.nih.gov]

virilization. [ncbi.nlm.nih.gov]

She demonstrated some of the features of Turner's syndrome, as well as virilization. On laparotomy, she was found to have bilateral gonadoblastomas. [ncbi.nlm.nih.gov]