Virilization: Causes & Reasons

Possible Causes for Virilization

21-hydroxylase deficiency in a newborn and a case of virilizing adrenal tumor in a four and half years old female child. [ncbi.nlm.nih.gov]

Occasionally, virilization occurs when a cancer outside the adrenal gland produces androgens. [msdmanuals.com]

Abstract After reviewing the causes of virilization in the newborn and grown female child, the Authors describe a case of congenital adrenal hyperplasia (S.A.G.C.) due to [ncbi.nlm.nih.gov]

Hilar Cell Tumor of the Ovary

Virilization secondary to an ovarian Leydig cell tumor. Management. [nature.com]

Summary A case of virilizing ovarian hilus cell tumor (Leydig-cell tumor) in a 37 year old female was studied by light and electron microscopy. [link.springer.com]

Print) eISSN: 1423-002X (Online) For additional information: https://www.karger.com/GOI Abstract A 58-year-old postmenopausal woman with high plasma testosterone levels and virilization [karger.com]

Polycystic Ovary Syndrome

Virilizing tumor: Women who present with symptoms of severe virilization or those who have a rapid onset of symptoms should have a thorough evaluation for a virilizing tumor [clinicaladvisor.com]

[…] grade of virilization. [ncbi.nlm.nih.gov]

[…] genitalia, although behavioural and ovulatory dysfunction can coexist without virilized genitalia based upon the timing of androgen excess. [ncbi.nlm.nih.gov]

Ovarian Androblastoma

The steroid profile of a virilizing ovarian tumor. Obstet. Gynecol. 52 : 73, 1978. PubMed Google Scholar 7. [link.springer.com]

Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. [finto.fi]

Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. [link.springer.com]

Adrenocortical Carcinoma

Report virilizing oncocytic adrenocortical carcinoma in a 50-year-old woman. [ncbi.nlm.nih.gov]

During follow-up, she gradually developed Cushingoid features and virilization. [ncbi.nlm.nih.gov]

A dramatic regression of virilization features occurred after adrenalectomy. [ncbi.nlm.nih.gov]

Achard Thiers Syndrome

congenital Adrenal hyperplasia, congenital, simple virilizing Adrenal hyperplasia, congenital, virilizing, non salt Adrenogenital disorder Congenital adrenal hyperplasia [icd9data.com]

- Adrenogenital disorders (& [feminisation] or [virilisation] or [Achard-Thiers syndrome]) (disorder) - Adrenogenital disorders (& [feminization] or [virilization] or [Achard-Thiers [snomedbrowser.com]

[…] female due to gestational hyperandrogenism Virilized XX, gestational hyperandrogenism 255.2 Excludes Applies To Adrenogenital syndromes, virilizing or feminizing, whether [icd9data.com]

Acquired Adrenogenital Syndrome

congenital Adrenal hyperplasia, congenital, simple virilizing Adrenal hyperplasia, congenital, virilizing, non salt Adrenogenital disorder Congenital adrenal hyperplasia [icd9data.com]

255.2 Hyperplasia, hyperplastic adrenal (capsule) (cortex) (gland) 255.8 with sexual precocity (male) 255.2 virilism, adrenal 255.2 virilization (female) 255.2 congenital [healthprovidersdata.com]

Adrenal virilism is rare and affects females twice as often as males. [family-health-information.com]

Neoplasm of the Ovary

Achard- Thiers syndrome 0 *Virilism *Ovarian Neoplasms *Diabetes Complications. TCEAL7 protein, human 0 *Nuclear Proteins Ovarian Neoplasms. [reference.md]

Sex cord-stromal tumor, including estrogen -producing granulosa cell tumor and virilizing Sertoli-Leydig cell tumor or arrhenoblastoma, accounts for 8% of ovarian cancers. [en.wikipedia.org]

Hirsutism, virilism and apparent virilism and their gonadal relationship. II. [sjmms.net]

Ovarian Dysgerminoma

Certain subtypes may occasionally be associated with isosexual precocity, dysgenetic gonads, virilization, hyperthyroidism or carcinoid syndrome. [orpha.net]

[…] producing : granulosa cell tumor and theca cell tumor Androgen producing: Sertoli-Leydig cell tumor Occurs very rarely; ∼ 20% malignant transformation Production of androgens → virilization [amboss.com]

These cells are known for their hormonal function which may lead to virilization or feminization of the opposite sex. [lecturio.com]

Epithelial Ovarian Cancer

A common symptom is known as virilism, which can include: infrequent menstrual periods menstrual periods after menopause appearance of facial hair a hoarse voice [ovariancanada.org]

Consequently, depending on the specific histology produced, these tumours can cause virilization in women and feminization in men. [en.wikipedia.org]

Androgen Therapy

Each of the subjects had male-gender behavior but incomplete virilization. [ncbi.nlm.nih.gov]

All had received long-term androgen therapy in fully virilizing doses, and two also received interval androgen therapy. [ncbi.nlm.nih.gov]

The subject who did not respond with clinical virilization nevertheless showed nitrogen retention in response to acute testosterone administration. [ncbi.nlm.nih.gov]

Anabolic Steroid

Oxandrolone does not virilize women in low to moderate doses and it has been used in children also. [thebody.com]

It also leads to virilization—the development of masculine traits, including increased libido and deepening of the voice. [britannica.com]

In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high risk of virilization despite the favourable myotrophic-androgenic [ncbi.nlm.nih.gov]

Androblastoma

We concluded that androblastomas, in spite of their low incidence, are a possibility that should always be considered in women of all ages presenting with signs of virilization [ncbi.nlm.nih.gov]

@article{WarenikSzymankiewicz2012BilateralA, title={Bilateral androblastoma (Sertoli-stromal cell tumor) of the ovary: a rare cause of virilization in a teenager.}, author [semanticscholar.org]

Lipid Cell Tumor of the Ovary

Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. [ncbi.nlm.nih.gov]

Abstract Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. [ncbi.nlm.nih.gov]

[…] of an ovarian virilizing tumor or ovarian hyperthecosis. [ncbi.nlm.nih.gov]

Gynandroblastoma

[…] ovarian tumor|Virilizing ovarian tumor (disorder) ICD 10 CM 2017, (Clinical Modification) for coding of death certificates and mortality data. [averbis.com]

The hormonal data obtained do not account for the marked virilization observed. [ncbi.nlm.nih.gov]

Gynandroblastoma usually presents clinically as an abdominal mass, often associated with either virilizing or feminizing manifestations. [ncbi.nlm.nih.gov]

Benign Ovarian Neoplasm

The female fetus had no signs of virilization. In mother all symptoms and effusions resolved. [ncbi.nlm.nih.gov]

[…] and virilization. [ijem.in]

Six patients, two of whom were virilized, were pregnant. Four tumors appeared malignant on histologic examination. [scienceopen.com]

Leydig Cell Tumor of the Testis

LCTs of the testis are frequently hormonally active, leading to either feminizing or virilizing syndromes. The tumor is usually benign, but malignant variants can occur. [ncbi.nlm.nih.gov]

A normally-virilized 24-year-old white man who had gynecomastia was found to have a Leydig-cell tumor of the testis, without demonstrable metastases. [ncbi.nlm.nih.gov]

Virilization (including precocious puberty) may occur. Hyperestrogenism may also occur and patients may demonstrate gynaecomastia. [radiopaedia.org]

Gonadoblastoma

The four patients with Y chromosome material had non-virilized female genitalia. [ncbi.nlm.nih.gov]

They can be distinguished from other tumoral causes of virilization by the presence of genital ambiguity since birth, presence of associated findings (maternal virilization [hindawi.com]

virilization. [ncbi.nlm.nih.gov]

Central Precocious Puberty

Abstract We present a 6-year-old boy with a virilizing adrenocortical tumor who initially presented with peripheral precocious puberty. [ncbi.nlm.nih.gov]

Pubertal outcome in a female with virilizing adrenocortical carcinoma. [ec.bioscientifica.com]

During therapy, we observed a decline in the level of free testosterone (Table 1 ) with an arrest of further virilization. [jmedicalcasereports.biomedcentral.com]

X-Linked Hypogonadotropic Hypogonadism without Anosmia

Virilization and feminization according to age alleviate the psychological burden and allow for the development of age-appropriate sexual behavior. [symptoma.com]

Congenital Isolated ACTH Deficiency

Vomiting Hyponatremia Hyperkalemia P450 oxidoreductase deficiency Severe virilization in females, severe under virilization in males No mineralocorticoid deficiency Craniofacial [arupconsult.com]

Classic 21-hydroxylase deficiency can be divided into 2 forms: Salt wasting Simple virilizing In both forms, adrenal androgen levels are elevated, causing virilization. [msdmanuals.com]

Typical findings of CAH Females with the salt wasting and simple virilizing forms of classical CAH present with ambiguous genitalia or virilization of a female genitalia in [clinicaladvisor.com]

Adrenal Cortical Adenoma

A virilizing, gonadotrophin-responsive adrenal cortical adenoma was removed from a 54-year-old woman. [ncbi.nlm.nih.gov]

Patients with virilization or feminization should be tested for androgens and estrogens respectively. [symptoma.com]

We recently experienced a 17-year-old pubertal girl who showed signs of virilization and a high serum level of testosterone. [ncbi.nlm.nih.gov]

Placental Aromatase Deficiency

Hirsutism Defined as excessive growth of androgen-responsive terminal hair in women excess hair growth in areas where hair growth is normally minimal Virilization Defined [medbullets.com]

Juli 2012 Publikationsdatum: 23.Oktober 2012 (eFirst) Conclusions AD is a cause of virilization in female fetus. [thieme-connect.com]

The mothers usually show the onset of progressive virilization during the third trimester. The male fetus has normal genitalia. See also disorders of sexual development [humpath.com]

Kallmann Syndrome Type 3

All 15 men had received previous hormonal therapy to induce virilization, fertility, or both. [f1000.com]

Alcohol-induced pseudo-Cushing's syndrome E24.8 Other Cushing's syndrome E24.9 Cushing's syndrome, unspecified E25 Adrenogenital disorders Includes: adrenogenital syndromes, virilizing [apps.who.int]

The choice for particular hormone replacement therapy protocol aimed at virilizing the patient will depend on age at diagnosis and local practices [ 4 ]. [omicsonline.org]

Adrenal Gland Neoplasm

Adrenal virilism is confirmed by the finding of an excess of serum androstenedione and dehydroepiandrosterone. [en.wikipedia.org]

Adrenocortical Hyperfunction: • Cushing Syndrome (ZF) • Hyperaldosteronism (ZG) • Virilizing syndromes (ZR) 2. [slideshare.net]

[…] remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization [icd.codes]

Leydig Cell Tumor

Virilization secondary to an ovarian Leydig cell tumor. [ncbi.nlm.nih.gov]

Virilization in childhood results from an adrenal and/or ovarian disorder. [ncbi.nlm.nih.gov]

Ovarian hilus or Leydig cell tumor and ovarian hilus cell hyperplasia are rare clinical entities, causing virilization in both pre- and postmenopausal women. [ncbi.nlm.nih.gov]

Sertoli Leydig Cell Tumor

After tumor ablation, a regular menstrual cycle followed and progressive reduction of virilism was noted. [ncbi.nlm.nih.gov]

Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. [connects.catalyst.harvard.edu]

Although they are the most common virilizing tumor of the ovary, about 60% are endocrine-inactive tumors. [ncbi.nlm.nih.gov]

Thecoma

virilizing tumor at her left ovary. [synapse.koreamed.org]

The virilizing manifestations were progressive from June 2003. She had no special past medical history and family history. [eymj.org]

A 29-year-old woman presented with secondary amenorrhea, primary infertility, and virilization, which had developed over the past 2 years was suspected to have a virilizing [ncbi.nlm.nih.gov]

Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

The extent of virilization may be the same in simple virilizing and salt-wasting CAH. [glowm.com]

High levels of androgens in women may cause virilization of the larynx and a masculine voice. [ncbi.nlm.nih.gov]

Also identifies the completely virilized girls with ambiguous genitalia who may be mistaken for boys with cryptorchidism how is CAH diagnosed prenatally? [quizlet.com]

Virilization

Most cases of virilization are due to congenital adrenal hyperplasia (CAH). [symptoma.com]

[…] hypertestosteronemia and virilization. [ncbi.nlm.nih.gov]

Virilization occurring in the postmenopausal woman may be either adrenal or ovarian in origin. [ncbi.nlm.nih.gov]