Whipple Disease: Causes & Reasons

Possible Causes for Whipple Disease

Short Bowel Syndrome National Institute of Diabetes and Digestive and Kidney Diseases Whipple’s Disease National Institute of Diabetes and Digestive and Kidney Diseases Clinical [chcrr.org]

Keywords Whipple disease; Malabsorption syndrome ; mucosa transplant; Infectious disease; Immunosuppressive therapy Introduction Whipple’s disease (WD) is a rare chronic and [omicsonline.org]

Whipples disease is a systemic bacterial illness usually affecting middle age men and presents diarrhea, arthritis, fever, weight loss, swollen lymph nodes and skin pigmentation [web.archive.org]

Neurologic Manifestation of Whipple Disease

This is a series of 12 patients with CNS Whipple’s disease, along with an analysis of 122 CNS Whipple’s disease cases reported in the literature. [link.springer.com]

Whipple in 1907, Whipple disease is a multisystem disorder that usually includes the intestinal tract. [neuropathologyblog.blogspot.com]

Epstein-Barr virus, histoplasmosis, Whipple’s disease, or syphilis. [shmabstracts.com]

Uveitis

[…] present with diarrhea and uveitis Crohn's dz Ulcerative colitis whipple disease what diseases present with jaundice and uveitis chronic, progressive inflammation of spine [studyblue.com]

[…] reactive arthritis sarcoidosis systemic lupus erythematosus Vogt–Koyanagi–Harada disease Whipple's disease [edit] Rifabutin, a derivative of Rifampin, has been shown to cause [en.wikipedia.org]

These included Behçet´s disease (n = 49), sarcoidosis (n = 64), Crohn´s disease (n = 30), multiple sclerosis (MS) (n = 25), ulcerative colitis (n = 14), Whipple´s disease [ojrd.biomedcentral.com]

Anemia

partial gastrectomy, systemic bacterial infection, Whipple’s disease Congenital abnormalities of folate metabolism Cyclohydrolase, methionine synthetase Combined deficit [dx.doi.org]

Disorders of terminal ileum: Tropical sprue, celiac disease, enteritis, exudative enteropathy, intestinal resection, Whipple disease, ileal tuberculosis, and cublin gene mutation [web.archive.org]

primary intestinal malabsorptive disorders, parasitic colonization, nutritional deficiencies Folate deficiency: diet poor in folates, regional enteritis, Whipple’s disease [dx.doi.org]

Dementia

Castle J, Sakonju A, Dalmau J, Newman-Toker DE: Anti-Ma2-associated encephalitis with normal FDG-PET: a case of pseudo-Whipple’s disease. [doi.org]

subacute sclerosing panencephalitis, syphilis, and Whipple's disease. [en.wikipedia.org]

Possible causes include brain infection (viral encephalitis, subacute sclerosing panencephalitis, Whipple's disease) or inflammation (limbic encephalitis, Hashimoto's encephalopathy [en.wikipedia.org]

Heart Valve Disease

disease, and Crohn disease.1 Diseases that primarily affect the annulus or aortic root include idiopathic aortic root dilatation, degeneration of the extracellular matrix [ncbi.nlm.nih.gov]

neoplasm, left atrial thrombus, infective endocarditis with large vegetations, certain inherited metabolic disorders such as Fabry’s disease, mucopolysaccharidosis, Whipple [textbookofcardiology.org]

Other systemic disorders that may affect the aortic valve include lupus erythematosus, giant cell arteritis, Takayasu arteritis, ankylosing spondylitis, Jaccoud arthropathy, Whipple [ncbi.nlm.nih.gov]

Intestinal Tuberculosis

MAC infection is also called pseudo-Whipple disease because of the diffuse mucosal fold thickening in the jejunum and histiocytic aggregates infected with MAC that stain positive [emedicine.medscape.com]

Cranial Neuropathy

Diabetes mellitus Hypothyroidism Acromegaly Nutritional diseases Alcoholism Vitamin B 12 deficiency Folate deficiency Whipple's disease Postgastrectomy syndrome Gastric restriction [aafp.org]

B 12 deficiency Folate deficiency Whipple's disease Postgastrectomy syndrome Gastric restriction surgery for obesity Thiamine deficiency Hypophosphatemia Critical illness [aafp.org]

View/Print Table TABLE 2 Distal Symmetric Sensorimotor Polyneuropathies Endocrine diseases Diabetes mellitus Hypothyroidism Acromegaly Nutritional diseases Alcoholism Vitamin [aafp.org]

Congestive Heart Failure

Severe congestive heart failure (CHF) patients are prone to hyponatremia. Peritoneal dialysis (PD) is increasingly used for long-term management of refractory CHF patients. The glucose polymer icodextrin was proposed to be a good option for fluid removal in such patients. A small, although statistically significant[…] [ncbi.nlm.nih.gov]

Epilepsy

Seizures, abnormal movements or behavior due to unusual electrical activity in the brain, are a symptom of epilepsy. But not all people who appear to have seizures have epilepsy, a group of related disorders characterized by a tendency for recurrent seizures. Non-epileptic seizures (called pseudoseizures) are not[…] [webmd.com]

Reiter Syndrome

See: Spondyloarthropathies - Discussion: - involves arthritis of large joints (knees & ankles), uveitis, skin lesions, & urethritis, however only a minority will have classic triad of symptoms; - conjunctivitis is observed early, usually before or at the onset of arthritis; - urethritis is usually mild and painless with[…] [wheelessonline.com]

Vitamin Deficiency

Micronutrient deficiencies, including vitamins and mineral deficiencies, are one of the major contributors to the global disease burden. Vitamin deficiencies increase the risk of infections and also cause premature death, poor health, blindness, stunted growth, mental retardation, learning disability and low work[…] [symptoma.com]

Intestinal Lymphangiectasia

Differential diagnosis includes constrictive pericarditis, intestinal lymphoma, Whipple's disease, Crohn's disease, intestinal tuberculosis, sarcoidosis or systemic sclerosis [ncbi.nlm.nih.gov]

Differential diagnosis The differential diagnosis includes enteropathy-associated T-cell lymphoma, Whipple disease, Crohn disease, sarcoidosis, tuberculosis (with extrapulmonary [orpha.net]

Congenital Malabsorption of Folic Acid

Dobbins WO: Whipple’s Disease. Springfield, Thomas, 1987. Wilson KH, Blitchington R, Frothingham R, Wilson JAP: Phylogeny of the Whipple disease-associated bacterium. [karger.com]

Diarrhea Lesions seen – classifid in to three Diffuse,specific e.g. whippl’s Disease Patchy, specific – crohn’s D., lymphoma infectious causes Diffuse,non-specific – celiac [slideplayer.com]

Whipple's disease also may require long-term use of antibiotics, such as tetracycline. [steadyhealth.com]

Carcinomatous Polyarthritis

’s disease Wilson’s disease Yersinial arthritis Sources: http://www.arthritis.org/types-arthritis.php, http://www.glucosamine-arthritis.org/arthritis/types-of-arthritis.html [buyprovailencheap.org]

disease Wilson's disease Yersinial arthritis [americanimagingpr.com]

’s disease Myofascial pain syndrome Wilson’s disease Enteropathic arthritis Yersinial arthritis Neonatal lupus Fabry’s disease Ochronosis Familial Mediterranean fever Olecranon [erheumatoidarthritissymptoms.com]

Classic Progressive Supranuclear Palsy Syndrome

Similar eye movement abnormalities can occur in Niemann-Pick disease type C and Whipple's disease (see these terms). [orpha.net]

Differential diagnosis Differential diagnosis includes Parkinson disease and other atypical parkinsonian disorders (APD) such as multiple system atrophy and corticobasal degeneration [orpha.net]

Congenital Enteropathy due to Enteropeptidase Deficiency

disease Wilson disease Zollinger-Ellison syndrome [se-atlas.de]

INTERVENTIONAL STUDIES OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, abetalipoproteinaemia etc.) [parasitetesting.com]

OGD to reveal duodenal lesion also for D2 biopsy (for celiac disease, tropical sprue, Whipple disease, A-b-lipoproteinemia etc.) [bionity.com]

Neurological Disorder

There is ample evidence that pinpoints neurological disorders as one of the greatest threats to public health. There are several gaps in understanding the many issues related to neurological disorders, but we already know enough about their nature and treatment to be able to shape effective policy responses to[…] [who.int]

Whipple Disease

A639 3 Antibiotic treatment and relapse in Whipple's disease. [jac.oxfordjournals.org]

Whipple disease is a progressively fatal disease, but once diagnosed correctly and treated promptly, it is completely cured. [symptoma.com]

Whipple first described the disease in 1907. [ncbi.nlm.nih.gov]

Gastrointestinal Sarcoidosis

Stains for Whipple’s disease and Mycobacterium were negative. [acgcasereports.gi.org]

disease (such as tuberculosis, syphilis, inflammatory bowel disease, Whipple’s disease), fungal infections (such as Histoplasma ), and H. pylori. 1, 4, 5 Gastric sarcoidosis [ncbi.nlm.nih.gov]

Primary Intestinal Lymphangiectasia

lymphoma, celiac disease, or Whipple disease. [ncbi.nlm.nih.gov]

Differential diagnosis includes constrictive pericarditis, intestinal lymphoma, Whipple's disease, Crohn's disease, intestinal tuberculosis, sarcoidosis or systemic sclerosis [ncbi.nlm.nih.gov]

Secondary intestinal lymphangiectasia usually develops as a consequence of lymph drainage obstruction that results from various conditions, including Whipple disease, mesenteric [consultant360.com]

Hereditary Orotic Aciduria without Megaloblastic Anemia

[…] vasculitides portal hypertension hypoproteinemia sprue scleroderma systemic lupus erythematosus: lupus enteritis Whipple disease amyloidosis drugs chemotherapy-induced The [radiopaedia.org]

[…] from radiation therapy Celiac disease Tropical sprue Whipple disease The inflammation can also involve the stomach (gastritis) and large intestine (colitis). [medlineplus.gov]

Etiology infection infective enteritis eosinophilic enteritis ischemia inflammatory bowel disease radiation radiation enteritis lymphoma intramural hemorrhage shocked bowel [radiopaedia.org]

Bladder Malakoplakia

Malakoplakia is morphologically very similar to Mycobacterium avium complex infection in AIDS patients and to Whipples disease and lepromatous leprosy. [pathpedia.com]

[2] In Whipple disease, the cytoplasmic granules are Sudan black positive whereas they are negative in malakoplakia. [jemds.com]

Radiation Enteritis and Colitis Pseudomelanosis Intestinalis Melanosis Coli Infectious Enteritis and Colitis -Bacteria Whipple Disease Mycobacterial Infections Bacterial [eneabrivio.com]

Palindromic Rheumatism

Palindromic rheumatism is the paradigm of this type of condition, but other diseases such as systemic autoinflammatory disorders (periodic fever syndromes), Whipple's disease [ncbi.nlm.nih.gov]

disease which is caused by the infectious agent Tropheryma whipplei (formerly T. whippelii ). [ citation needed ] Anti-citrullinated protein antibody is frequently associated [en.wikipedia.org]

Besides crystal arthritis, the most frequent cause of recurrent arthritis, there are several diseases that may present clinically as intermittent mono- or polyarthritis. [ncbi.nlm.nih.gov]

Seronegative Arthritis

They include: psoriatic arthritis reactive arthritis ankylosing spondylitis enteropathic arthritis Whipple’s disease non-radiographic axial spondyloarthritis Each of these [healthline.com]

"Fever of unknown origin with seronegative spondyloarthropathy: an atypical manifestation of Whipple's disease". Ann. Rheum. [en.wikipedia.org]

[…] needed ] and Whipple's disease. [7] Common characteristics [ edit ] These diseases have the following conditions in common: Seronegative (i.e. rheumatoid factor is not present [en.wikipedia.org]

Juvenile Seronegative Polyarthritis

[…] classified elsewhere [See site code at the beginning of this chapter ] Excludes: arthropathy in Whipple's disease ( M14.8* ) M09.0* Juvenile arthritis in psoriasis ( L40.5 [apps.who.int]

’s Disease, and various types of arthritis caused by bacteria (Lyme arthritis, Gonococcal arthritis, Rheumatic fever, tuberculous arthritis). [rheumatoid-arthritis-decisions.com]

[…] classified elsewhere Arthropathy in: · erythema: · multiforme ( L51.-+ ) · nodosum ( L52+ ) · sarcoidosis ( D86.8+ ) · Whipple's disease ( K90.8+ ) Processed on 11/12/2006 [apps.who.int]

Arthritis due to Ulcerative Colitis

Pathology While EA has been classically described with ulcerative colitis and Crohn disease, other gastrointestinal diseases, such as Whipple disease, celiac disease, and [radiopaedia.org]

Other gastrointestinal conditions that affect bones and muscles include intestinal bypass (jejunoileal) arthritis, celiac disease, Whipple disease, and collagenous colitis [arthritis.org]

Whipple's disease arthritis : This occurs most commonly in middle-aged men. [patient.info]

Syphilitic Arthritis

disease Wilson's disease Yersinial arthritis [americanimagingpr.com]

Whipple’s disease, Behçet’s disease Arthritis and urethritis – disseminated gonococcal infection What tests to perform? [rheumatologyadvisor.com]

disease – a rare infection with Tropheryma whipplei that affects multiple organs such as the heart and the lungs, with joint pain as well Further Reading What is Arthritis [news-medical.net]

Protein-Losing Enteropathy

eosinophilic gastroentropathy, sarcoidosis, Whipple's disease, infections–giardiasis, bacterial overgrowth, viral enteritis, schistosomiasis, C difficile, pulmonary artery [medical-dictionary.thefreedictionary.com]

Increased interstitial pressure or lymphatic obstruction due to : Tuberculosis Sarcoidosis Retroperitoneal fibrosis Lymphoma Intestinal endometriosis Lymphoenteric fistula Whipple [healthhype.com]

[…] carcinoid tumor, melanoma, nontropical sprue, ulcerative colitis, intestinal lymphangiectasia, CHF, constrictive pericarditis, superior vena cava thrombosis, Ménétrier's disease [medical-dictionary.thefreedictionary.com]

Celiac Disease with Diffuse Intestinal Ulceration

’s Disease • Glycoprotein in the lamina propria of the small bowel is Sudan-negative, PAS-positive • Clinically: arthralgia, abdominal pain, diarrhea and weight loss • Treated [learningradiology.com]

[…] approximation of the valvulae (hide-bound appearance) (stack-of-coins) • Does not have increased secretions as does sprue • May be associated with pneumatosis intestinalis Whipple [learningradiology.com]