Possible Causes for White Eyebrows Tietz Syndrome Clinical description Affected cases have a pale skin, blue eyes and light blond to white hair with white eyebrows and eyelashes. [orpha.net] eyebrow Pale eyebrow 0002226 Percent of people who have these symptoms is not available through HPO Autosomal dominant inheritance 0000006 Bilateral sensorineural hearing [rarediseases.info.nih.gov] Hearing impairment Deafness Hearing defect [ more ] 0000365 Hypopigmentation of hair Loss of hair color 0005599 Hypopigmentation of the skin Patchy lightened skin 0001010 White [rarediseases.info.nih.gov] Waardenburg Syndrome Type 4C eyebrow White eyelashes White forelock Abnormality of the nervous system Aganglionic megacolon Anosmia Ear malformation Sensorineural hearing loss disorder IMPORTANT NOTE [ncbi.nlm.nih.gov] White eyebrow MedGen UID: 373165 •Concept ID: C1836737 • Finding White color (lack of pigmentation) of the eyebrow. [ncbi.nlm.nih.gov] eyebrow White eyelashes White forelock Frequently present symptoms in 30-79% of the cases: Olfactory lobe agenesis Prominent nasal bridge Synophrys Underdeveloped nasal alae [dovemed.com] Waardenburg Syndrome Type 4A eyebrow White eyelashes White forelock Abnormality of the musculoskeletal system Hypotonia Abnormality of the nervous system Aganglionic megacolon Cerebellar ataxia Global [ncbi.nlm.nih.gov] White eyebrow MedGen UID: 373165 •Concept ID: C1836737 • Finding White color (lack of pigmentation) of the eyebrow. [ncbi.nlm.nih.gov] eyebrow White eyelashes White forelock Frequently present symptoms in 30-79% of the cases: Olfactory lobe agenesis Prominent nasal bridge Synophrys Underdeveloped nasal alae [dovemed.com] Waardenburg Syndrome Type 2E eyebrow White eyelashes White forelock Abnormality of the musculoskeletal system Axial hypotonia Hypertonia Pectus excavatum Abnormality of the nervous system Anosmia Cerebral [ncbi.nlm.nih.gov] eyebrow Abnormality of the integument Cafe-au-lait spot Hypopigmented skin patches Premature graying of hair White eyebrow White eyelashes White forelock Abnormality of the [familydiagnosis.com] eyebrow ; White eyelashes ; White forelock Associated Genes SOX10 (Withdrawn symbols: DOM, WS2E, WS4 ) Mouse Orthologs Sox10 (Withdrawn symbols: Dom, Sox21, gt ) Source OMIM [mousephenotype.org] Waardenburg Syndrome Type 4B Figure 1 Figure 2 Figure 3 Figure 4 Discussion Shah-Waardenburg syndrome is an unusual variant of Waardenburg syndrome that is associated with white forelock, white eyebrows [escholarship.org] eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [ more ] 0002227 White forelock White part of hair above forehead 0002211 Showing of 35 | Last [rarediseases.info.nih.gov] eyebrows and eyelashes as well, which is not seen in other types of Waardenburg Syndromes. [en.wikipedia.org] Klein-Waardenburg Syndrome […] skin Eyebrows extending toward middle of face Nose abnormalities Premature graying of the hair (by age 30) Waardenburg syndrome type 2 is defined as having all the features [verywell.com] Clinical description Patients usually present in the neonatal period with pigmentary anomalies (including white forelock, eyebrows and eyelashes, heterochromia of the irides [orpha.net] Furthermore, Piebaldism with white pigment-less hair strands on the forehead hairline in the area of the midline as well as medially localized white parts of the eyebrows [altmeyers.org] Piebaldism […] skin patches Patchy loss of skin color 0001053 Macule Flat, discolored area of skin 0012733 White eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [rarediseases.info.nih.gov] […] forelock unpigmented skin beneath the forelock white eyebrows and eyelashes symmetrical non pigmented patches on the face and body narrow border of hyperpigmented skin surrounding [dynamicnaturesite.blogspot.com] He also had loss of pigment of the medial eyebrows and a white forelock. [escholarship.org] Peripheral Demyelinating Neuropathy - Central Dysmyelination - Waardenburg Syndrome - Hirschsprung Disease Waardenburg Syndrome Type 2A eyebrow White eyelashes White forelock Ear malformation Sensorineural hearing loss disorder IMPORTANT NOTE: NIH does not independently verify information submitted to the [ncbi.nlm.nih.gov] White eyebrow MedGen UID: 373165 •Concept ID: C1836737 • Finding White color (lack of pigmentation) of the eyebrow. [www-ncbi-nlm-nih-gov.ezproxy.u-pec.fr] […] in the midline) White skin patches (leukoderma) and white forelock of hair (poliosis) Pigmentary abnormalities of the eyes are less common than the skin and hair changes; [dermnetnz.org] Waardenburg Syndrome Type 2D eyebrow (白色眉毛) [HP:0002226] [1726] White eyelashes (白色睫毛) [HP:0002227] [1734] Wide nasal bridge (幅広い鼻梁) [HP:0000431] [0703] (UR-DBMS) 【眼】内眼角外方偏位なし 虹彩異色症 【耳】先天性両側性感音難聴 [syndromefinder.ncchd.go.jp] […] in the midline) White skin patches (leukoderma) and white forelock of hair (poliosis) Pigmentary abnormalities of the eyes are less common than the skin and hair changes; [dermnetnz.org] eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [ more ] 0002227 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal bridge [rarediseases.info.nih.gov] Autism with Facial Nevus Flammeus This elder is standing and he is a tall and thin bearded man with long white hair without eyebrows. [m.webnovel.com] Waardenburg Syndrome Type 2C White eyebrow MedGen UID: 373165 •Concept ID: C1836737 • Finding White color (lack of pigmentation) of the eyebrow. [www-ncbi-nlm-nih-gov.ezproxy.u-pec.fr] eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [ more ] 0002227 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal bridge [rarediseases.info.nih.gov] […] forelock, eyebrows, or eyelashes Dystopia canthorum – lateral displacement of inner canthi First degree relative with Waardenburg syndrome Minor criteria Hypopigmented patches [dermnetnz.org] Deoxyribose-5-Phosphate Aldolase Deficiency White eyebrow, White eyelashes, Synophrys, Heterochromia... [mousephenotype.org] eyebrow, White eyelashes, Heterochromia iridis, White forelock, Premature gray... [mousephenotype.org] OMIM:300908 Piebaldism Heterochromia iridis, Hypopigmentation of hair, White eyebrow, White eyelashes, Synophrys, Piebal... [mousephenotype.org] Familial Transverse Nasal Hyperpigmentation ORPHA:2251 Waardenburg Syndrome, Type 4B Sensorineural hearing impairment, Blue irides, White eyebrow, White eyelashes, Heterochromia irid... [mousephenotype.org] ORPHA:158681 Oculocutaneous Albinism Type 3 Blue irides, Hypopigmentation of the skin, Iris hypopigmentation, White eyebrow, White eyelashes,... [mousephenotype.org] eyebrow, A... [mousephenotype.org] Waardenburg Syndrome Type 2 Note the bit of white hair and bit of white eyebrow. Waardenburg Syndrome Type 2 is caused by a MITF Gene mutation. [colorgenetics.info] eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [ more ] 0002227 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal bridge [rarediseases.info.nih.gov] […] skin Eyebrows extending toward middle of face Nose abnormalities Premature graying of the hair (by age 30) Waardenburg syndrome type 2 is defined as having all the features [verywell.com] Waardenburg Syndrome Type 2B eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [ more ] 0002227 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal bridge [rarediseases.info.nih.gov] […] congenital deafness, pigmentation of the iris and skin, and white forelock. [semanticscholar.org] The eyebrows, eyelashes, and scalp hair may become prematurely gray or white (beginning as early as mid-childhood, adolescence, or early adulthood). [rarediseases.org] Waardenburg Syndrome Type 1 Underdeveloped nasal alae ; White eyebrow ; White eyelashes ; White forelock ; Wide nasal bridge Associated Genes PAX3 (Withdrawn symbols: HUP2, WS1 ) Mouse Orthologs Pax3 [mousephenotype.org] Bushy eyebrows Dense eyebrow Heavy eyebrows Prominent eyebrows Thick eyebrows [ more ] 0000574 White eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [rarediseases.info.nih.gov] […] skin Eyebrows extending toward middle of face Nose abnormalities Premature graying of the hair (by age 30) Waardenburg syndrome type 2 is defined as having all the features [verywell.com] Waardenburg Syndrome […] irides in the left eye and a broad nasal root (d) Click here to view Figure 2: Clinical photographs showing white forelock, blue eyes, white eyebrows and eyelashes, broad [e-fjs.org] white forelock, and deaf-mutism. [pubmed.ncbi.nlm.nih.gov] […] forelock, eyebrows, or eyelashes Dystopia canthorum – lateral displacement of inner canthi First degree relative with Waardenburg syndrome Minor criteria Hypopigmented patches [dermnetnz.org] Piebald Trait - Neurologic Defects Syndrome […] forelock White eyelashes White eyebrow Piebaldism Abnormal bleeding Ocular albinism Cirrhosis Diplopia Spastic paraparesis Blue irides Abnormality of movement Retinopathy [mendelian.co] In some patients, white macules also manifest on eyebrow and eyelash hair either continuously or discontinuously with the white forelock. [clinicaladvisor.com] 60 Frequent (79-30%) 18 white forelock 33 HP:0002211 19 absent pigmentation of the ventral chest 33 HP:0007542 [malacards.org] White Lock of Occipital Hair /hypopigmented area of hairs of head, moustache, eyelashes, eyebrows, beard or another place. [medigoo.com] but it can involve any hairy area of the body, including the eyebrows, eyelashes, and beard [2]. [ncbi.nlm.nih.gov] Poliosis has also been described as "white forelock" when its location involves the frontal scalp, however, poliosis can involve various body areas including the eyebrows, [scholars.direct] Ermine Phenotype eyebrow Pale eyebrow 0002226 White eyelashes Blonde eyelashes Pale eyelashes [ more ] 0002227 White hair 0011364 Showing of 22 | Last updated: 5/1/2019 If you need medical [rarediseases.info.nih.gov] […] through HPO Albinism 0001022 Autosomal recessive inheritance 0000007 Spotty hyperpigmentation Spotty increased pigmentation 0005585 Vitiligo Blotchy loss of skin color 0001045 White [rarediseases.info.nih.gov] Usher Syndrome Type 1H White eyebrow MedGen UID: 373165 •Concept ID: C1836737 • Finding White color (lack of pigmentation) of the eyebrow. [www-ncbi-nlm-nih-gov.ezproxy.u-pec.fr] Abnormality of head or neck Blepharophimosis Mandibular prognathia Oral cleft Smooth philtrum Synophrys Telecanthus Thick eyebrow Underdeveloped nasal alae White eyebrow White [www-ncbi-nlm-nih-gov.ezproxy.u-pec.fr] White eyebrow White eyelashes White forelock Abnormality of the musculoskeletal system Congenital elevation of scapula Mandibular prognathia Supernumerary ribs Supernumerary [www-ncbi-nlm-nih-gov.ezproxy.u-pec.fr] Gupta Patton Syndrome […] irides in the left eye and a broad nasal root (d) Click here to view Figure 2: Clinical photographs showing white forelock, blue eyes, white eyebrows and eyelashes, broad [e-fjs.org] Figure 1: Clinical photographs showing white forelock and partial albinism in the patient, (a and b) blue eyes and white eyebrows and eyelashes, (c) while his father has heterochromia [e-fjs.org] We identified three male patients fulfilling the diagnostic criteria for WS (white forelock with the involvement of eyebrows and eyelashes, pigmentary disturbances of the [e-fjs.org] ABCD Syndrome White eyebrow MedGen UID: 373165 •Concept ID: C1836737 • Finding White color (lack of pigmentation) of the eyebrow. [ncbi.nlm.nih.gov] […] forelock, eyebrows, or eyelashes Dystopia canthorum – lateral displacement of inner canthi First degree relative with Waardenburg syndrome Minor criteria Hypopigmented patches [dermnetnz.org] Thirdly, "hypertrichosis of the medial part of the eyebrows" is present, meaning excessive hair growth in the patients’ eyebrow region, most likely leading to a unibrow. [en.wikipedia.org] ATP7A-Related Copper Transport Disorders Shortly thereafter, hair changes become manifest: the scalp and (usually) eyebrow hair is short, sparse, coarse, twisted, and often lightly pigmented (white, silver, or gray [ncbi.nlm.nih.gov] Hirschsprung Disease - Deafness - Polydactyly Syndrome eyebrow Sprengel anomaly Myelomeningocele Lacrimation abnormality White forelock White hair Hypopigmentation of the fundus Supernumerary ribs White eyelashes Partial albinism [mendelian.co] (synophyrys), white forelock, heterchromia iridis, and deafness. [neoreviews.aappublications.org] (50%) Partial or total heterochromia irides (25%) Circumscribed albinism of the frontal head hair or white forelock (20%) Sensorineural deafness, unilateral or bilateral [emedicine.medscape.com] OPHN1 Syndrome eyebrow, White eyelashes,... [mousephenotype.org] ORPHA:96369 Ermine Phenotype Spotty hyperpigmentation, Albinism, White eyelashes, Vitiligo, White eyebrow, White hair OMIM:227010 Spastic Paraplegia, Intellectual Disability [mousephenotype.org] Brittle hair, Sparse eyelashes, Coarse hair OMIM:234030 Tietz Syndrome Hypopigmentation of the skin, White eyebrow, Hypopigmentation of hair, Abnormality of skin pigmen. [mousephenotype.org] Eyebrow Duplication - Syndactyly Syndrome The medial eyebrows and the eyelashes may be involved. [pediatricsconsultant360.com] eyebrow Anteriorly placed anus Abnormality of the face Underdeveloped supraorbital ridges Limited elbow extension Gingival overgrowth Palmoplantar keratoderma Small nail [mendelian.co] About 90% of patients with classic piebaldism have a white forelock that emanates from a midline, symmetrical, triangular, elongated or diamond-shaped white macule. [pediatricsconsultant360.com] Facial Seborrhea […] or yellowish scales that may feel oily or dry and are located on the scalp, eyelids, eyebrows, or lips. [medical-dictionary.thefreedictionary.com] The signs and symptoms include: White flakes on shoulders of dark clothing Itchy scalp Scaly facial skin Recurrent ear " eczema " Facial rash over eyebrows, nose, and ears [emedicinehealth.com] It can affect the scalp, eyebrows, forehead, face, folds around the nose and ears, the chest, armpits, and groin. [encyclopedia.com] Vitiligo Other symptoms of vitiligo can include: white skin hairs where your skin is white early onset of gray or white hair on your head (less than 35 years of age) white eyebrows [familydoctor.org] Often, a patch of hair on the head, an eyelash or eyebrow turns white. Color loss often occurs for a year or two, and then stops. [apderm.com] eyelashes, or beard white patches in your mouth (mainly in people who have a darker skin color to begin). [familydoctor.org]