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148 Possible Causes for White Matter Vacuolization

  • Vitamin B12 Deficiency

    […] and demyelinating lesions in the white matter and in the posterior and lateral columns.[ispub.com] […] the pathological process seen in vitamin B12 deficiency; macroscopically the cord is shrunken in the anteroposterior diameter while microscopically there are multifocal vacuolated[ispub.com]

  • Anemia

    Microscopic: Multifocal vacuolated and demyelinated lesions exist in the white matter of the posterior and lateral columns.[web.archive.org] The posterior and lateral columns may be gray-white in color.[web.archive.org]

  • Stroke

    Microscopic evaluation during the first 24 to 48 hours discloses anoxic neurons, vacuolization of the white matter due to disentanglement of swellings of myelin and axon.[symptoma.com]

  • Brain Stem Infarction

    Microscopical examination in the first 24 to 48 hours reveals anoxic neurons , pallor of staining and vacuolization of the white matter due to unraveling of myelin, and axonal[neuropathology-web.org]

  • Parkinson's Disease

    White matter changes in patients with CTX suggest the coexistence of demyelinating and axonopathic lesions in CTX [ 45 ].[doi.org] Cerebral WM lesions and cerebellar vacuolation have been described in a patient with CTX with progressive ataxia [ 49 ],[ 75 ].[doi.org]

  • Propionic Acidemia

    Neuropathologic changes previously reported in infants have been white-matter vacuolization or spongiosis.[ncbi.nlm.nih.gov] […] different pathology, namely, spongy degeneration of the white matter of Van Bogaert and Bertrand's type.[ncbi.nlm.nih.gov] Although previous pathologic reports of this disorder describe either no involvement of the central nervous system or focal myelin sheath vacuolization, the present case exhibited[ncbi.nlm.nih.gov]

  • CNS Metastasis

    Review of serial brain MRIs showed development of multifocal T2/FLAIR hyperintensities in cerebral hemisphere white matter, basal ganglia and cerebellum, mild contrast enhancement[neurology.org] Cerebellar lesion biopsy revealed vacuolization and sparse axonal swelling, consistent with myelinolysis, and lipid-laden macrophages.[neurology.org]

  • Meningoencephalitis

    […] and gray matter and leptomeninges.[onlinelibrary.wiley.com] Ultrastructurally, these macrophages contained typical lentiviral particles within membrane‐bound intracytoplasmic vacuoles.[onlinelibrary.wiley.com] […] approximately 60% of the experimentally inoculated animals had a meningoencephalitis characterized by perivascular infiltrates of macrophages and multinucleate giant cells in the white[onlinelibrary.wiley.com]

  • Vascular Dementia

    Haltia Diffuse vacuolization (spongiosis) and arteriolosclerosis in the frontal white matter occurs in vascular dementia Arch Neurol, 53 (1996), pp. 325-332 [33.] G.[elsevier.es]

  • Cerebral Embolism

    Microscopical examination in the first 24 to 48 hours reveals anoxic neurons , pallor of staining and vacuolization of the white matter due to unraveling of myelin, and axonal[neuropathology-web.org]

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