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12 Possible Causes for Widespread Atrophy of Retinal Pigment Epithelium

  • Central Serous Chorioretinopathy

    Abstract Background Central serous chorioretinopathy (CSC) is a widespread retinal disorder, and 30-50% of patients eventually result in retinal pigment epithelium atrophy[ncbi.nlm.nih.gov]

  • Leber Congenital Amaurosis

    […] centered about the fovea "Bone-spicule" intraretinal pigment migration Widespread subretinal flecks resembling retinitis punctata albescens "Marbled" fundus Discrete pigmented[ncbi.nlm.nih.gov] […] nummular lesions at the level of the retinal pigment epithelium (RPE) Optic disc abnormalities: swelling, drusen formation, and peripapillary neovascularization Oculo-digital[ncbi.nlm.nih.gov] […] variety of abnormalities may develop either in isolation or combination: "Macular coloboma"; not a true coloboma, but reflecting discrete chorioretinal degeneration and atrophy[ncbi.nlm.nih.gov]

  • Neuronal Ceroid Lipofuscinosis 2

    Posterior segment findings ranged from a completely unremarkable dilated exam, OCT, FA, and ICGA to a severe, widespread retinal atrophy with complete absence of the outer[journals.plos.org] […] retinal structures and the retinal pigment epithelium (RPE, Figures 1-5 ).[journals.plos.org]

  • Central Areolar Choroidal Dystrophy

    Three cases of one manifestation, geographic atrophy of the retinal pigment epithelium, are described with emphasis on differential diagnosis from a clinically similar disease[wikigenes.org] CACD produces a widespread photoreceptor dysfunction in its later stages [11].[wikigenes.org]

  • Ocular Siderosis

    All eyes had all the clinical features of siderosis both in the anterior and posterior segments with widespread retinal pigment epithelium atrophy and vitritis.[evrs.eu]

  • Chloroquine Retinopathy

    Advanced cases may demonstrate widespread retinal pigment epithelium atrophy, with a reduced visual field and decreased night vision. 3 Visual field.[retinalphysician.com] Early changes may include minimal pigment epithelial mottling or atrophy with loss of foveal reflex.[retinalphysician.com] Later, central pigmentation develops with a hollow of depigmentation, mainly inferior to the fovea, creating the “bull’s eye” pattern.[retinalphysician.com]

  • Late-Onset Retinal Degeneration

    Dilated fundus examination revealed scalloped areas of retinal pigment epithelium (RPE) atrophy in the mid-periphery and widespread atrophy in the posterior pole.[ncbi.nlm.nih.gov] Peripupillary iris atrophy and long anterior zonular insertions were present in three of four patients.[ncbi.nlm.nih.gov]

  • Bietti Crystalline Dystrophy

    Pigment Epithelium (RPE) Atrophy and Pigment Accumulation.[healio.com] pigment epithelium (RPE) atrophy and pigment accumulation (Fig. 1 ).[healio.com] Fundus autofluorescence (FAF) revealed widespread hypo-autofluorescence corresponding to diffuse RPE atrophy, and multiple hyper-autofluorescent areas in correspondence of[healio.com]

  • Phenothiazine

    Over time, the retinopathy evolves to widespread but patchy atrophy of the pigment epithelium and choriocapillaris, with a characteristic nummular pattern of involvement ([aao.org] Initially, patients complain of blurred vision, and the fundus shows coarse retinal pigment stippling in the posterior pole ( Fig 10-13A ).[aao.org]

  • Mazzotti Reaction

    Characteristic chorio-retinal lesions are atrophy or hyperplasia of the retinal pigment epithelium, chronic non-granulomatous chorioretinitis and chorioretinal atrophy.[vertigoexercises.us] These are typically widespread, unlike in toxoplasmosis, and usually are first seen temporal to the macula.[vertigoexercises.us]

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