Create issue ticket

12 Possible Causes for Widespread Atrophy of Retinal Pigment Epithelium

  • Central Serous Chorioretinopathy

    Abstract Background Central serous chorioretinopathy (CSC) is a widespread retinal disorder, and 30-50% of patients eventually result in retinal pigment epithelium atrophy[]

  • Leber Congenital Amaurosis

    […] centered about the fovea "Bone-spicule" intraretinal pigment migration Widespread subretinal flecks resembling retinitis punctata albescens "Marbled" fundus Discrete pigmented[] […] nummular lesions at the level of the retinal pigment epithelium (RPE) Optic disc abnormalities: swelling, drusen formation, and peripapillary neovascularization Oculo-digital[] […] variety of abnormalities may develop either in isolation or combination: "Macular coloboma"; not a true coloboma, but reflecting discrete chorioretinal degeneration and atrophy[]

  • Neuronal Ceroid Lipofuscinosis 2

    Posterior segment findings ranged from a completely unremarkable dilated exam, OCT, FA, and ICGA to a severe, widespread retinal atrophy with complete absence of the outer[] […] retinal structures and the retinal pigment epithelium (RPE, Figures 1-5 ).[]

  • Central Areolar Choroidal Dystrophy

    Three cases of one manifestation, geographic atrophy of the retinal pigment epithelium, are described with emphasis on differential diagnosis from a clinically similar disease[] CACD produces a widespread photoreceptor dysfunction in its later stages [11].[]

  • Ocular Siderosis

    All eyes had all the clinical features of siderosis both in the anterior and posterior segments with widespread retinal pigment epithelium atrophy and vitritis.[]

  • Chloroquine Retinopathy

    Advanced cases may demonstrate widespread retinal pigment epithelium atrophy, with a reduced visual field and decreased night vision. 3 Visual field.[] Early changes may include minimal pigment epithelial mottling or atrophy with loss of foveal reflex.[] Later, central pigmentation develops with a hollow of depigmentation, mainly inferior to the fovea, creating the “bull’s eye” pattern.[]

  • Late-Onset Retinal Degeneration

    Dilated fundus examination revealed scalloped areas of retinal pigment epithelium (RPE) atrophy in the mid-periphery and widespread atrophy in the posterior pole.[] Peripupillary iris atrophy and long anterior zonular insertions were present in three of four patients.[]

  • Bietti Crystalline Dystrophy

    Pigment Epithelium (RPE) Atrophy and Pigment Accumulation.[] pigment epithelium (RPE) atrophy and pigment accumulation (Fig. 1 ).[] Fundus autofluorescence (FAF) revealed widespread hypo-autofluorescence corresponding to diffuse RPE atrophy, and multiple hyper-autofluorescent areas in correspondence of[]

  • Phenothiazine

    Over time, the retinopathy evolves to widespread but patchy atrophy of the pigment epithelium and choriocapillaris, with a characteristic nummular pattern of involvement ([] Initially, patients complain of blurred vision, and the fundus shows coarse retinal pigment stippling in the posterior pole ( Fig 10-13A ).[]

  • Mazzotti Reaction

    Characteristic chorio-retinal lesions are atrophy or hyperplasia of the retinal pigment epithelium, chronic non-granulomatous chorioretinitis and chorioretinal atrophy.[] These are typically widespread, unlike in toxoplasmosis, and usually are first seen temporal to the macula.[]

Further symptoms