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7 Possible Causes for Xanthine Dehydrogenase Activity Decreased

  • Molybdenum Cofactor Deficiency Complementation Group B

    Molybdenum cofactor deficiency also causes loss of activity of xanthine dehydrogenase, which functions in purine degradation (converting hypoxanthine to xanthine and then[clinicaladvisor.com] This leads to decreased levels of both serum and urinary uric acid. Elevated excretion of xanthine may ultimately lead to renal stones in survivors of MCD.[clinicaladvisor.com]

  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    Molybdenum cofactor deficiency also causes loss of activity of xanthine dehydrogenase, which functions in purine degradation (converting hypoxanthine to xanthine and then[clinicaladvisor.com] This leads to decreased levels of both serum and urinary uric acid. Elevated excretion of xanthine may ultimately lead to renal stones in survivors of MCD.[clinicaladvisor.com]

  • Xanthinuria

    Dysfunction of this variant was confirmed by significantly decreased xanthine dehydrogenase/oxidase activity in the patient's plasma ( 2% of control mean activity).[ncbi.nlm.nih.gov] dehydrogenase activity in the duodenal mucosa below the limits of detection.[ncbi.nlm.nih.gov] Routine laboratory data showed hypouricemia, a high level of plasma oxypurines, decreased urinary uric acid excretion, and increased urinary oxypurine excretion, with xanthine[ncbi.nlm.nih.gov]

  • Deficiency of Sulfite Oxidase

    Liver sulfite oxidase activity was not detectable but xanthine dehydrogenase activity was normal. The boy died of respiratory failure at 32 months.[ncbi.nlm.nih.gov] Molybdenum cofactor deficiency also causes loss of activity of xanthine dehydrogenase, which functions in purine degradation (converting hypoxanthine to xanthine and then[cancertherapyadvisor.com] There was increased urine excretion of sulfite and S-sulfocysteine and a decreased concentration of plasma cystine. A lactic acidemia was present for 6 months.[ncbi.nlm.nih.gov]

  • Disulfiram

    Disulfiram competes with nicotinamide adenine dinucleotide for the active centers of the enzyme aldehyde dehydrogenase, and also decreases the oxygen consumption and the xanthine[jamanetwork.com] Disulfiram competes with nadide (nicotinamide adenine dinucleotide) for the active centers of the enzyme, aldehyde dehydrogenase, and also decreases the oxygen consumption[jamanetwork.com] […] oxidase, succinoxidase, and catalase activity of liver homogenates. 1 Warfarin inhibits enzyme systems in the liver cell which synthesize prothrombin. 1 No reports were found[jamanetwork.com]

  • Xanthinuria Type 1

    Xanthinuria is a rare autosomal recessive disorder caused by mutations in the xanthine dehydrogenase (XDH) gene leading to a deficiency or decreased activity of this enzyme[docksci.com] See also OMIM:278300 Mutagenesis Feature key Position(s) Description Actions Graphical view Length Mutagenesis i 803 E V: Strongly decreased activity towards xanthine and[uniprot.org] It is characterized by hypouricemia, reductions in urinary UA excretion, and increases in the plasma and urinary levels of xanthine and hypoxanthine [5].[docksci.com]

  • Allopurinol

    Hypoxia regulates xanthine dehydrogenase activity at pre- and posttranslational levels.[ncbi.nlm.nih.gov] Xanthine oxidase decreases production of gut wall nitric oxide.[ncbi.nlm.nih.gov]

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