Xerostomia: Causes & Reasons

Possible Causes for Xerostomia

Xerostomia was significantly more common and severe in patients (46.9%) than in healthy controls, whereas the saliva flow rates did not differ. [ncbi.nlm.nih.gov]

Xerostomia is the most consistent and bothersome side effect of radiation therapy. A preventive approach and early treatment are important. [ncbi.nlm.nih.gov]

Poor oral hygiene is commonplace among this group, as is smoking and xerostomia, which also contribute to the development of denture stomatitis. [ncbi.nlm.nih.gov]

Sjögren Syndrome

Xerostomia Other names Dry mouth,[1] dry mouth syndrome[2] Xerostomia, also known as dry mouth,[1] is dryness in the mouth, which may be associated with a change in the composition [en.wikipedia.org]

Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are [ncbi.nlm.nih.gov]

Eye dryness and xerostomia were assessed by the Schirmer's test, the Fox test and the visual analogue scale (VAS). [ncbi.nlm.nih.gov]

Radiation Stomatitis

Glycerol Spray for Management of Psychotropic Drug-Induced Xerostomia Xerostomia (mouth dryness) often occurs as an unwanted effect of psychotropic drugs. [medlife.pharmacy]

Pilocarpine Troches for Xerostomia Pilocarpine is indicated for the treatment of xerostomia secondary to radiation therapy of the head and neck. [pottershouserx.com]

Archives of Oral Biology. 2011 April; 56(4): 395-400 Pilocarpine Troches for Xerostomia Pilocarpine is indicated for the treatment of xerostomia secondary to radiation therapy [medlife.pharmacy]

Triple A Syndrome

Conclusion We recommend the investigation of salivation in all patients with triple A syndrome and treatment of xerostomia in order to ease swallowing. [ncbi.nlm.nih.gov]

The importance of this case report is to highlight the necessity of referring the young patients with xerostomia from dental to medical specialists. [ncbi.nlm.nih.gov]

Xerostomia in patients with triple A syndrome–a newly recognised finding. Eur J Pediatr. 2000;159(12):885–888. 65. [dovepress.com]

Primary Biliary Cirrhosis

She was 38 years old and was admitted to our hospital for generalized pruritus, xerostomia, xerophthalmia, fatigue, and reticulonodular changes on her chest X-ray. [ncbi.nlm.nih.gov]

Pinto A: Management of xerostomia and other complications of Sjögren's syndrome. Oral Maxillofac Surg Clin North Am 2014;26:63-73. [karger.com]

(25%) Hyperpigmentation (25%) Splenomegaly (15%) Jaundice (10%) Xanthelasma (10%) - In late stages of the disease Sicca syndrome (50-75%) - Xerophthalmia (ie, dry eyes), xerostomia [emedicine.medscape.com]

Systemic Scleroderma

(SSc) is an autoimmune disease that affects connective tissue, resulting in hardening skin, reduced vascular perfusion, gingival fibrosis, enlarged periodontal ligament, xerostomia [ncbi.nlm.nih.gov]

Abstract Scleroderma is a disorder involving oral and facial tissues, with skin hardening, thin lips, deep wrinkles, xerostomia, tongue rigidity, and microstomia. [ncbi.nlm.nih.gov]

Muscle weakness Muscular weakness 0001324 Osteolysis Breakdown of bone 0002797 Pulmonary fibrosis 0002206 Skin ulcer Open skin sore 0200042 Telangiectasia of the skin 0100585 Xerostomia [rarediseases.info.nih.gov]

Amantadine Toxicity

[…] capsules Treatment of dyskinesia or “off” episodes in patients with Parkinson disease receiving concomitant levodopa-based therapy 100 98 Gastrointestinal: Constipation (13%), xerostomia [5minuteconsult.com]

Lambert-Eaton Syndrome

 She also described intense muscular pain, a loss of 10 kg in 10 months, xerostomia, and reduction of the libido. 3. ??What are the signs and symptoms??? [slideshare.net]

Both patients in this report presented xerostomia and reduction of the libido. [scielo.br]

A 68‑year‑old male patient presented with a 6‑month history of progressive weakness of the proximal limbs and a 2‑month history of xerostomia. [spandidos-publications.com]

Diffuse Cutaneous Systemic Scleroderma

Rheumatoid Arthritis

Sjogren’s syndrome is an autoimmune condition that affects exocrine gland function, leading to a reduction in tear production (keratoconjunctivitis sicca), oral dryness (xerostomia [hopkinsarthritis.org]

Sjögren’s syndrome used in this and other studies, 36, 37 the frequency of the diagnosis depends heavily on the availability of specific tests for the evaluation of possible xerostomia [doi.org]

Amyloidosis

Areas of swelling, hemorrhages under the skin (purpura), hair loss (alopecia), inflammation of the tongue (glossitis) and a dry mouth (xerostomia) may also be present. [rarediseases.org]

Multicentric Castleman's Disease

Additional complaints consistent with MCD are xerostomia, rash and neurological deficits. [symptoma.com]

Radiotherapy

Intensity-modulated radiation therapy (IMRT) is an increasingly available approach to the prevention of xerostomia. [emedicine.medscape.com]

Xerostomia (dry mouth) Radiation therapy that is delivered to the head and neck area may also result in xerostomia. [web.archive.org]

Given in a daily dose, amifostine is to be used in the prevention of radiation-induced xerostomia in the postoperative setting. [emedicine.medscape.com]

Anticholinergic

OBJECTIVE: The aim was to study whether the anticholinergic burden of drugs is related to xerostomia and salivary secretion among community-dwelling elderly people. [ncbi.nlm.nih.gov]

The frequency of patients with a high AIS score, greater than 5, was significantly higher in patients who received laxatives and treatments of xerostomia. [ncbi.nlm.nih.gov]

‘The administration of antihypertensive and anticholinergic medications also impairs salivary functions and promotes xerostomia.’ [en.oxforddictionaries.com]

Belladonna Tincture

Side effects include xerostomia, hoarseness, visual disorders. [tankonyvtar.hu]

[…] extract as a flavouring Hyperthyroidism Ephedra sinica Ephedra, Ma Huang Ephedrae herba Ephedra Ephedra intermedia Zhong Ma Huang Ephedra equisetina Muzei Ma Huang Dry mouth (xerostomia [tankonyvtar.hu]

Diphenhydramine

While xerostomia can be a mild aggravation for the patient and may not appear to be clinically relevant, chronic xerostomia can increase the risk for dental caries as well [ebmconsult.com]

Closely All Interactions Sort By: Adverse Effects Frequency Not Defined Sedation Confusion Anticholinergic effects May decrease cognitive function in geriatric patients Xerostomia [reference.medscape.com]

Incidence not known Mild drowsiness / Early / 22.1-22.1 restlessness / Early / 1.0-10.0 asthenia / Delayed / 4.4-4.4 headache / Early / 2.5-2.5 dizziness / Early / 2.5-2.5 xerostomia [pdr.net]

Oral Candidiasis

In patients with T1D and neuropathy, more cases of xerostomia and decreased salivary flow were reported. [dentalcare.com]

It is generally associated with predisposing factors such as the use of immunosuppressive agents, antibiotics, prostheses, and xerostomia. [ncbi.nlm.nih.gov]

Similarly, the occurrence of xerostomia during RT was significantly higher in the OIRR group (86.2%) than in the ONIRR group (52.9%). [ncbi.nlm.nih.gov]

Acute Amphetamine Intoxication

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TTR Amyloidosis with Polyneuropathy

[…] autonomic disturbances were not present in most patients when seen the first time, orthostatic hypotension, diarrhea/stypsis, erectile dysfunction, urinary incontinence, xerostomia [content.iospress.com]

Areas of swelling, hemorrhages under the skin (purpura), hair loss (alopecia), inflammation of the tongue (glossitis) and a dry mouth (xerostomia) may also be present. [rarediseases.org]

At last follow-up, autonomic involvement (orthostatic hypotension, diarrhea/stypsis, erectile dysfunction, urinary incontinence, xerostomia) paralleled sensory and motor dysfunction [content.iospress.com]

Acute Kidney Injury

Swiss Med Wkly. 2012 Aug 14;142:w13662. doi: 10.4414/smw.2012.13662. eCollection 2012. Author information 1 Pediatric Cardiac Anesthesia/Intensive Care Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, Rome, Italy. accaria.ricci@gmail.com Abstract The term acute kidney injury (AKI)[…] [ncbi.nlm.nih.gov]

Radiation Exposure

It prevents xerostomia in patients undergoing radiation therapy. [merckmanuals.com]

It is used clinically to prevent xerostomia in patients undergoing radiation therapy. [msdmanuals.com]

Hemochromatosis

Hemochromatosis is the abnormal accumulation of iron in parenchymal organs and the most common form of iron overload disease. It may be inherited or acquired. The patients suffering from hemochromatosis have the following clinical picture. The skin of these patients acquires a bronze pigmentation due to the[…] [symptoma.com]

Tricyclic Antidepressant

The blockade of these receptors gives as a result: Anticholinergic (atropine-like) effects: blurred vision, xerostomia, urinary retention, constipation and narrow angle glaucoma [pharmacologycorner.com]

Dehydration

Abstract This hospital-record review describes the clinical profile of hypernatremic dehydration in neonates. 49 neonates (3.4% of the total admitted newborns) developed hypernatremic dehydration between January 2014 and August 2015. The major presenting complaints were fever (34.6%), poor feeding (42.8%), loose[…] [ncbi.nlm.nih.gov]

Panic Disorder

Abstract Numerous studies have provided evidence for the effectiveness of cognitive behavioral therapy (CBT) on panic disorders (PDs). There has also been growing attention on brief CBT with regard to delivering intensive treatment efficiently. This study investigated the essential parts of mindfulness-based[…] [ncbi.nlm.nih.gov]

Salivary Gland Disorder

Causes severe xerostomia. 12. [slideshare.net]

Individuals with xerostomia complain of dry mouth and throat and associated difficulty with mastication and swallowing. [asams.org]

Other supposed symptom complexes have been identified (sialadenitis, nodal osteoarthritis and xerostomia, SOX). [pocketdentistry.com]

Sialadenitis

Xerostomia-related symptom scores post-sialendoscopy did not differ significantly from the pre-sialendoscopy scores. [ncbi.nlm.nih.gov]

The aim of this study is to clarify the therapeutic effects of LIPUS on xerostomia in SS. [ncbi.nlm.nih.gov]

Commonly Associated Conditions Postoperative dehydration Radiation-induced xerostomia Drug-induced xerostomia Sjögren syndrome Hypercalcemia -- To view the remaining sections [unboundmedicine.com]

Antidepressant

antipsychotics, dopamine antagonists, and nonpsychiatric MAOIs (eg, linezolid, IV methylene blue) May cause anticholinergic effects; use with caution in patients with xerostomia [reference.medscape.com]

Temporal Arteritis

References: Giant cell arteritis and polymyalgia rheumatica. Family Doctor—American Academy of Family Physicians website. Available at: http://familydoctor.org/familydoctor/en/diseases-conditions/giant-cell-arteritis-and-polymyalgia-rheumatica.html. Updated March 2014. Accessed June 30, 2015. Giant cell arteritis (including[…] [wnyurology.com]

Hepatopathy

Abstract The increase of the prevalence of nonalcoholic fatty liver disease in the context of the explosive epidemy of obesity worldwide over the last decades and the emergence of new effective therapies for viral hepatitis has brought this entity to the forefront of hepatologist concerns. Today is a certainty[…] [ncbi.nlm.nih.gov]