Cerebral palsy. As the neurologic symptoms of OPA3-related methylglutaconic aciduria are relatively slow to progress, especially if the optic atrophy is not recognized, the disorder may be misdiagnosed as cerebral palsy [Straussberg et al 1998]. [ncbi.nlm.nih.gov]

Some children with 3MGA have developmental delays. If you think that your baby is not meeting their developmental milestones, ask your child's health care provider about the next steps in accessing a developmental evaluation and care. [babysfirsttest.org]

Failure to thrive and psychomotor retardation are common. Microcephaly and progressive neurologic impairment with spastic quadriplegia, seizures, and dystonia have been reported. [Sweetman & Williams 2001, Ijlst et al 2002, Illsinger et al 2004]. [ncbi.nlm.nih.gov]

The mode of inheritance and the lack of skeletal myopathy and neutropenia distinguish DCMA syndrome from Barth syndrome. [ncbi.nlm.nih.gov]

spasms and weakness in the arms and legs (called spastic quadriparesis) 3MGA type II (Barth syndrome) signs include: Frequent infections Weak muscles Delayed growth 3MGA type III (Costeff optic atrophy syndrome) signs include: Vision loss Trouble with [babysfirsttest.org]

Most individuals in this group present early in life with nonspecific neurologic findings including psychomotor retardation and muscle tone abnormalities. Cardiomyopathy is common. [ncbi.nlm.nih.gov]

Some of the reported patients also displayed hypoglycaemia, spastic quadriparesis, microcephaly, progressive neurological deficit, seizures, vomiting, atrophy of the basal ganglia, severe hypotonia and hepatomegly. [orpha.net]

Seizures are not typical in OPA3-related 3-methylglutaconic aciduria. Partial seizures were reported in one individual. Individuals with OPA3-related 3-methylglutaconic aciduria have no cardiac or structural brain abnormalities. [ncbi.nlm.nih.gov]

Although most develop spastic paraparesis, mild ataxia, and occasional mild cognitive deficit in their second decade, the course of the disease is relatively stable. [ncbi.nlm.nih.gov]

Type IV has signs similar to types I, II, and III. 3MGA type V (dilated cardiomyopathy with ataxia) signs include: Difficulty coordinating voluntary muscle movements (called ataxia) Delayed growth Undescended testes or an opening in the urethra on the [babysfirsttest.org]

Sometimes other nervous system problems occur, such as an inability to maintain posture, poor muscle tone, the development of certain involuntary movements (extrapyramidal dysfunction), and a general decrease in brain function (cognitive deficit). [en.wikipedia.org]