After a month she presented with grayish transverse melanonychia along and parallel to the lunula with some maceration of the periungal folds. [ncbi.nlm.nih.gov]

• Intravenous Administration

  In H22 tumor-bearing mice models, treatment with EMC-5-FU was more efficacious in tumor inhibition compared to 5-FU intravenous administration. [pubs.rsc.org]

  Intravenous administration of gastrointestinal toxicity is often limiting dose. On the contrary, huge doses of intravenous injection, white cell reduction is the dose limiting toxicity. [chemicalbook.com]

  Ninety percent of the dose is accounted for during the first 24 hours following intravenous administration. [web.archive.org]

• Soft Tissue Mass

  Lesions could not have been treated with radiotherapy and had to measure ≥ 10 mm (lung) or ≥ 20 mm (liver, soft tissue masses). Ascites and pleural effusions were not considered measurable. [doi.org]

• Diarrhea

  Catechols/therapeutic use Chemokine CXCL1/metabolism* Colon/drug effects Colon/pathology Diarrhea/chemically induced Diarrhea/pathology Diarrhea/prevention & control* Disease Models, Animal Drugs, Chinese Herbal/chemistry Drugs, Chinese Herbal/pharmacology [ncbi.nlm.nih.gov]

  There are insufficient data on the risks of resumption of fluorouracil in patients with neurologic toxicity that has resolved. 5.5 Diarrhea Fluorouracil can cause severe diarrhea. [dailymed.nlm.nih.gov]

  diarrhea lasting more than 48 hours [ 22, 23 ]. [bmccancer.biomedcentral.com]

  Follow regimen of anti-diarrhea medication as prescribed by your health care professional. Eat foods that may help reduce diarrhea (see managing side effects - diarrhea ). Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing. [chemocare.com]

• Strabismus

  [J Pediatr Ophthalmol Strabismus. 2016;53:e54-e57.]. Copyright 2016, SLACK Incorporated. [ncbi.nlm.nih.gov]

• Alopecia

  Revised SPC: Efudix Cream (fluorouracil) 10 January 2014 - Publisher: Glenmark Pharmaceuticals Europe Ltd Section 4.8 has been updated to include dysgeusia, conjunctival irritation, keratitis, increased lacrimation, urticarial and alopecia as undesirable [evidence.nhs.uk]

  Overdose and treatment Signs and symptoms of overdose include myelosuppression, diarrhea, alopecia, dermatitis, hyperpigmentation, nausea, and vomiting. [glowm.com]

  Alopecia and dermatitis commonly occur. [medical-dictionary.thefreedictionary.com]

  However, patients receiving capecitabine plus oxaliplatin experienced less all-grade diarrhea and alopecia, and more neurosensory toxicity, vomiting, and HFS than with 5-FU/LV. [link.springer.com]

  Alopecia and dermatitis may be seen in a substantial number of cases. The dermatitis most often seen is a pruritic maculopapular rash usually appearing on the extremities and less frequently on the trunk. [web.archive.org]

• Dermatitis

  Continue Related Articles Seborrheic Dermatitis in Skin of Color: Clinical Considerations.... [jddonline.com]

  Skin: reversible alopecia, dermatitis, erythema, scaling, pruritus, nail changes, pigmented palmar creases, erythematous contact dermatitis, desquamative rash of hands and feet with long-term use ("hand-foot syndrome"). [glowm.com]

  The treatment had to be discontinued because of toxicity in four patients; one case of contact dermatitis, one case of erosive pustular dermatosis, and two cases of Grade 2 irritations. [ncbi.nlm.nih.gov]

  Read More Original Research A Cohort Study on a Ceramide-Containing Cleanser and Moisturizer Used for Atopic Dermatitis Author: Charles W. [mdedge.com]

  Irritant contact dermatitis or allergic contact dermatitis may affect some or all treated areas, including skin that is not sun damaged. [dermnetnz.org]

• Skin Rash

  One patient developed grade 3 thrombocytopenia and grade 3 skin rash that resolved with discontinuation of 5-FU and supportive care, while second patient developed grade 4 thrombocytopenia, grade 3 coagulopathy and grade 3 neurological toxicity with a [ncbi.nlm.nih.gov]

  Rarely, patients can be allergic to 5-FU cream and develop a severe allergic skin rash. Where can I get more information about 5-FU cream? Links to patient support groups: www.patient.co.uk/medicine/Fluorouracil-Cream.htm [esms-mohs.eu]

  […] burning, itching, sensitivity, stinging, or watering Increased sensitivity of the skin to sun and ultraviolet light Pain and burning of the affected area Dryness, scaling or swelling of the affected area Skin rash, itching of the affected area Tenderness [verywellhealth.com]

  The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: severe stomach pain bloody diarrhea vomiting fever chills severe red skin rash Fluorouracil may cause other side effects. [nlm.nih.gov]

  Published studies have shown that workplace exposures to hazardous drugs can cause both acute and chronic health effects such as skin rashes, adverse reproductive outcomes (including infertility, spontaneous abortions, and congenital malformations), and [healthycanadians.gc.ca]

• Eczema

  How often or for how long you should use 5-FU cream will depend on your skin condition and other factors, for example which part of your skin is affected or if you also have another skin complaint such as eczema. 5-FU cream can for example be applied [esms-mohs.eu]

  […] evidence of severe, uncontrolled auto-immune, cardiovascular, gastrointestinal, hematological, hepatic, neurological, pancreatic, pulmonary or renal disease Dermatologic conditions if present on the face such as: atopic dermatitis, basal cell carcinoma, eczema [clinicaltrials.gov]

  Do not put on cuts, scrapes, eczema, or damaged skin. Do not put on healthy skin. Do not let the skin where fluorouracil (topical) was used touch anyone else's skin after you have used fluorouracil (topical). [drugs.com]

  Do not put on cuts, scrapes, eczema, or damaged skin. Do not put on healthy skin. Do not let the skin where this drug was used touch anyone else’s skin after you have used this drug. [mskcc.org]

• Facial Papule

  papules developed within a week of starting topical treatment of his actinic keratoses with 5-FU. [ncbi.nlm.nih.gov]

• Ataxia

  Neurologic symptoms included confusion, disorientation, ataxia, or visual disturbances. Withhold fluorouracil for neurologic toxicity. [dailymed.nlm.nih.gov]

  The generally described syndrome is central, with an acute brain disorder, characterized by ataxia, which can be accompanied by muscle weakness, bilateral paralysis of the oculomotor nerve and signs of involvement of the first motor neuron. [scielo.br]

  Reversible cerebellar ataxia occurs in 1% of patients, possibly is related to the dose, occur at any time of the treatment process (often a few months later). After Cerebellar signs in the withdrawal can be last for a few of weeks. [chemicalbook.com]

  Symptoms include ataxia (trouble walking), intellectual impairment, and changes in behavior. Call your provider immediately if you notice any of these symptoms. [oncolink.org]

Treatment efficacy assessment was based on a comparison of tumor measurements before and after 3 months of treatment. Treatment continued until progressive disease, or intolerable toxicity, or the patient declined treatment. [doi.org]

Albeit rarely, exacerbation of rosacea by topical 5-FU treatment has been described when 5-FU was introduced as a topical treatment for actinic keratosis.Conclusion Topical 5-FU has been associated with several adverse cutaneous events, including accentuation [ncbi.nlm.nih.gov]

Owing to metastasis and resistance, the prognosis of colorectal cancerCRC patients remains extremely poor with chemotherapy. [ncbi.nlm.nih.gov]

Gorham disease (GD) is a rare osteolytic condition of unknown etiology that causes spontaneous, progressive bone resorption. The maxillofacial area is one of the regions most frequently involved in this disease. [ncbi.nlm.nih.gov]

The etiology of dysgeusia from chemotherapeutic agents and systemic absorption of fluorouracil is discussed. [jddonline.com]

Its etiology is unknown, and currently there is no cure... Read More [mdedge.com]

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, and the Obstetrics–Gynecology Epidemiology Center, Brigham and Women’s Hospital, Boston, Massachusetts. [journals.lww.com]

Epidemiology of solar keratoses. Br J Dermatol. 1994;131:455–464. 7. Berman B, Bienstock L, Kuritzky L, et al. Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel. J Fam Pract. 2006;55(Suppl):1–8. 8. [jcadonline.com]

Author information 1 Department of Analytical Pathophysiology, Division of Pharmacy Professional Development and Research, Hoshi University. 2 Division of Cancer Pathophysiology, National Cancer Center Research Institute. 3 Department of Pharmacology, [ncbi.nlm.nih.gov]

There is an unmet need for management of cardio-oncology conditions, which is predicted to reach epidemic proportions, and better understanding of their pathophysiology and treatment is urgently required. [icrjournal.com]

This association allows for a comparison between the pathophysiologies responsible for each of the clinical contexts and the use of similar therapeutic schemes. [scielo.br]

Stein A, Voigt W, Jordan K: Chemotherapy-induced diarrhea: Pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol 2:51-63, 2010. 52. Adrucil (fluorouracil injection) Prescribing Information. [ascopost.com]

We found that rebamipide prevented 5-fluorouracil (5-FU)-induced cell death in NHOK cells. [ncbi.nlm.nih.gov]

[…] or reduces its normal utilization. radiosensitizing agent A drug that makes increases the sensitivity of tumour cells to radiation therapy. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent [ebi.ac.uk]

Fluorouracil prevents the formation of RNA which, in turn, prevents the formation of DNA. As a result, cells cannot multiply. With continued treatment, the remaining cells also die. The FDA approved fluorouracil in July 1970. [medicinenet.com]