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Abnormal Gastrointestinal Motility


Presentation

  • Symptoms suggestive of esophageal, small bowel, or colonic involvement were present from 1 1/2 to 40 years. All patients had elevated antinuclear antibody (ANA) titers.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Abnormalities in GI motility may be an early presenting sign of disorders of OXPHOS in children.[ncbi.nlm.nih.gov]
  • CONCLUSION: Abnormalities in GI motility may be an early presenting sign of disorders of OXPHOS in children.[nature.com]
  • Gastrointestinal abnormalities may be an early presenting sign of mitochondrial disease (Chitkara, 2003).[mitoaction.org]
  • The presenting faculty reported the following: Dr.[consultant360.com]

Workup

Treatment

  • Hyman Abstract Background In chronically ill children who refuse to eat, surgery to correct anatomic problems and behavioral treatments to overcome oral aversion often succeed. A few patients fail with standard treatments.[doi.org]
  • If these treatments don't relieve pain, surgery might be needed to repair the sphincter muscle.[my.clevelandclinic.org]
  • This must be done because treatment of pseudo-obstruction and true obstruction are very different.[ddc.musc.edu]
  • At California Pacific Medical Center, more than 45 gastroenterology doctors provide personalized patient care using the most advanced diagnostic and treatment options available.[cpmc.org]
  • In most cases treatment does not cure gastroparesis – it is usually a chronic condition. However, in most people treatment does help manage the condition. Learn More about Gastroparesis Achalasia Achalasia is an esophageal motility disorder.[iffgd.org]

Prognosis

  • Ultrasonography or computed tomography showing characteristic changes in a patient who uses little or no alcohol confirms the diagnosis. 24 CLINICAL FEATURES, COURSE, AND PROGNOSIS Most patients with nonalcoholic fatty liver disease are asymptomatic.[aafp.org]

Etiology

  • But the etiology of the intestinal motility disorders cannot be fully explained by physiological causes alone.[pennmedicine.org]
  • Gastric Emptying Study Center Medically Reviewed on 6/14/2018 References Medically reviewed by Venkatachala Mohan, MD; Board Certified Internal Medicine with subspecialty in Gastroenterology REFERENCE: "Gastroparesis: Etiology, clinical manifestations[medicinenet.com]
  • Hyperglycemia and poor glycemic control play a substantial role in gastroparesis, both as an etiologic factor and a clinical manifestation.[consultant360.com]
  • Sometimes an empiric trial of antibiotics and/or pancreatic enzymes is warranted because pancreatic exocrine insufficiency and bacterial overgrowth may be the etiology.[journal.diabetes.org]
  • The etiology is unknown, but the disease is often associated with type 2 diabetes and obesity. In some cases, nonalcoholic fatty liver disease may progress to nonalcoholic steato-hepatitis with varying degrees of inflammation and fibrosis.[aafp.org]

Epidemiology

  • EPIDEMIOLOGY A constellation of GI symptoms occurs commonly in persons with diabetes and may be caused by autonomic dysfunction, as well as by other factors.[consultant360.com]
Sex distribution
Age distribution

Pathophysiology

  • The aims of the study were to: 1) investigate motility and gastric sensory abnormalities and 2) describe treatment that was individualized based on pathophysiology in children who failed surgery and behavioral treatments.[doi.org]
  • Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease . Cell 1988; 55 :601–610. 11. Zheng, X , Shoffner, JM , Lott, MT , et al.[nature.com]
  • The pathophysiology of these gastrointestinal symptoms, clarified in recent studies, and the clinical features and treatment of these problems in diabetic patients are reviewed. FULL TEXT[annals.org]
  • Despite the important consequences that malfunction of the GI tract has for PD patients, there is a dearth of information concerning the pathophysiology and treatment of GI symptoms in PD because there is no laboratory model known to mimic the GI symptoms[michaeljfox.org]
  • PATHOPHYSIOLOGY There are a number of different causes of gastroparesis ( Table I3 ), yet the underlying pathophysiology remains unclear.[consultant360.com]

Prevention

  • Achalasia – prevents the sphincter from opening and allowing food to enter the stomach. Gastro-esophageal reflux disease (GERD) – caused by the stomach’s acidic contents leaking backwards up into the esophagus.[winthrop.org]
  • Learn More about Constipation Outlet obstruction type constipation (pelvic floor dyssynergia) The external anal sphincter, which is part of the pelvic floor normally stays tightly closed to prevent leakage.[iffgd.org]
  • Can gastrointestinal disease be prevented? Many diseases of the colon and rectum can be prevented or minimized by maintaining a healthy lifestyle, practicing good bowel habits, and submitting to cancer screening.[my.clevelandclinic.org]
  • This sensation of rectal filling enables us to consciously or unconsciously squeeze the external anal sphincter to prevent incontinence until we can reach a toilet.[drossmangastroenterology.com]
  • The muscles located here open up to allow food to pass into the stomach but quickly close down thereafter in order to prevent any stomach contents from going back up into the esophagus.[study.com]

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