Most commonly the acanthoma presents as a small, very slow-growing, firm, solitary nodule on the lower limb in late middle-aged persons. [jamanetwork.com]

Tennstedt, Dominique [UCL] Lachapelle, Jean-Marie [UCL] Five cases of spectacle-frame acanthoma are reported; four were retro-auricular (three unilateral; one bilateral) and one was present on the left side of the nose. [dial.uclouvain.be]

• Sweating

  In addition our ninth patient showed hyperplasia of sweat ducts beneath the acanthoma. In three cases we were able to make certain histochemical observations on unfixed frozen sections. [jamanetwork.com]