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Accelerated Atherosclerosis


Presentation

  • We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years.[ncbi.nlm.nih.gov]
Plethora
  • Monocytes and macrophages respond to and govern inflammation by producing a plethora of inflammatory modulators, including cytokines, chemokines, and arachidonic acid (C20:4)-derived lipid mediators.[ncbi.nlm.nih.gov]
  • There has been a plethora of studies conducted to determine role of risk factors in the acceleration of atherosclerosis in individuals with compromised renal function.[webmedcentral.com]
Intravenous Administration
  • Carotid ultrasonography (US), transcranial Doppler (TCD), brain magnetic resonance imaging (MRI), and SPECT after intravenous administration of tracer 99mTc-HMPAO (dose: 720MBq) were performed.[ncbi.nlm.nih.gov]
Recurrent Infection
  • Abstract Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, and an increased risk of autoimmune disease and malignancy, and so chronic inflammation.[ncbi.nlm.nih.gov]
Vascular Disease
  • Increased understanding of the role of ACSL1 and other culprits in monocytes/macrophages in inflammation and diabetes-accelerated atherosclerosis offers hope for new treatment strategies to combat diabetic vascular disease.[ncbi.nlm.nih.gov]
  • Abstract Vascular injury represents a critical initiating event in the pathogenesis of various vascular diseases, including atherosclerosis.[onlinejacc.org]
  • What is the evidence that patients with HIV have an increased incidence of coronary and vascular disease? Metabolic abnormalities have been associated with HAART drugs.[healio.com]
  • Abstract Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are[portal.research.lu.se]
Muscle Weakness
  • A 52-year-old Caucasian woman with end-stage renal disease was admitted to our hospital with progressive muscle weakness and skin induration resulting in growing immobility.[ncbi.nlm.nih.gov]

Workup

ST Elevation
  • METHODS: We studied 77 patients with CAD: 45 affected by unstable angina/non-ST elevation myocardial infarction [acute coronary syndrome (ACS)], and 32 by chronic coronary syndrome (CCS).[ncbi.nlm.nih.gov]
White Matter Lesions
  • Increasing internal carotid artery pulsatility index (PI-ICA) was associated with decreasing mean flow velocity (MFV)-MCA (P .038), increasing PI-MCA (P .008) and increasing white matter lesions on MRI (P .011).[ncbi.nlm.nih.gov]

Treatment

  • There is currently no known preventative treatment of premature atherosclerosis in SLE. Mycophenolate mofetil (MMF) is an immunosuppressive agent that is commonly used for treatment of patients with SLE.[ncbi.nlm.nih.gov]

Prognosis

  • Due to modern immunosuppressive therapy, prognosis in SLE patients has markedly improved.[intechopen.com]
  • It is therefore vital that primary and secondary prevention strategies are implemented early on in CKD, which would inevitably lead to a better prognosis for such patients.[webmedcentral.com]

Etiology

  • The syndromes of accelerated atherosclerosis (namely, heart transplant atherosclerosis, coronary vein graft disease and restenosis after percutaneous transluminal coronary angioplasty) appear to share etiologic mechanisms with spontaneous atherosclerosis[onlinejacc.org]
  • The multifactorial etiology of atherosclerosis makes it difficult to unambiguously determine why SLE patients develop atherosclerotic lesions earlier in life and more frequently than the general population.[intechopen.com]

Epidemiology

  • Although conflicting reports exist, these epidemiological studies support this connection. Paralleling these epidemiological studies, emerging basic scientific studies also support that infection may represent a risk factor for atherosclerosis.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • In this scientific statement, there is an integration of the various factors that putatively underlie the association of MDD and BD with CVD, including pathophysiological mechanisms, traditional CVD risk factors, behavioral and environmental factors,[ncbi.nlm.nih.gov]
  • Better understanding of the nature of vascular injury and its pathophysiologic responses in these clinical situations may aid in developing therapeutic strategies for preventing these vascular diseases. Received December 1, 1959.[onlinejacc.org]
  • The pathophysiology of acute coronary syndromes. Heart 2000; 83:361-366. Available on: . Accessed on: 7/3/13 22. Insull W.[webmedcentral.com]

Prevention

  • Furthermore, treatment of DMLDLR(-/-) mice with S17834 prevented the decrease in AMPK and ACC phosphorylation and the lipid accumulation in the liver, and it also inhibited hyperlipidemia and the acceleration of aortic lesion development.[ncbi.nlm.nih.gov]
  • New free-calcium and -aluminum phosphate binders, new vitamin D metabolites, and calcimimetics are examples of "second-generation" therapies that may prevent vascular calcification and possibly prevent some of the burden of cardiovascular disease in uremia[moh-it.pure.elsevier.com]

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