This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. [doi.org]

Increased sympathetic tone is often initially present, and most patients present with a sinus tachycardia, with or without hypertension. [calpoison.org]

We present a retrospective observational study of severe anticholinesterase insecticide poisoning, with particular reference to mode of presentation and outcome, in children requiring intensive care over a 10 year period. [adc.bmj.com]

• Hypoxemia

  Paralysis of the respiratory muscles in combination with bronchorrhea, bronchoconstriction, and CNS depression leads to hypoxemia and respiratory arrest, which is the most common cause of death. [calpoison.org]

• Sputum

  His oxygenation continued to fall, and he began coughing up pink-tinged, frothy sputum. He continued to have large amounts of vomiting and diarrhea. [calpoison.org]

Although dementia remains incurable, early recognition presents the opportunity to start cholinesterase inhibitors before substantial neuronal loss occurs. 3, 4 Patient workup. [mdedge.com]

In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. [doi.org]

DISCUSSION: EEG spectral analysis could be shown to rapidly reflect the cerebral cholinergic action of short-term acetylcholinesterase inhibitor treatment. [ncbi.nlm.nih.gov]

However, information on the evolution of nutritional status and its impact on the prognosis of AD is still scarce. [ncbi.nlm.nih.gov]

QTC prolongation indicates a poor prognosis in patients with organophosphate poisoning. Am J Emerg Med1996;14:451–3. Read the full text or download the PDF: Log in using your username and password [adc.bmj.com]

Designed to serve as a trusted desktop reference on mental disorders seen across the lifespan for mental health professionals at all levels of experience, Diagnosis and Treatment of Mental Disorders Across the Lifespan, Second Edition expertly covers etiology [books.google.com]

Alzheimer’s disease (AD) is well-known as a severe neurodegeneration disease involving complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical intervention in AD management. [pubs.acs.org]

[…] now convincing evidence for a powerful interaction between these disease processes when coexistent 6,7 and further evidence that these conditions coexist more often than would be expected by chance as a result of shared risk factors and possibly patho-etiological [stroke.ahajournals.org]

Etiology of acute coronary syndrome after noncardiac surgery. Anesthesiology. 2018;128:1084–1091. 39. Behling A, Moraes RS, Rohde LE, Ferlin EL, Nóbrega AC, Ribeiro JP. [journals.lww.com]

Epidemiology In 2007, Californians reported over 700 exposures to OP and carbamate pesticides to the CPCS. Nationally, more than 15,000 poisonings with these chemicals are reported to poison control centers each year, with five or six fatalities. [calpoison.org]

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med. 2007;4:e297. Cited Here | PubMed 17. van Buuren S. [journals.lww.com]

Dr Gill is an assistant professor in the departments of Medicine and Community Health and Epidemiology at St Mary’s of the Lake Hospital in Kingston, Ontario. Dr Rochon is V.P. Research at Women’s College Research Institute in Toronto, Ontario. [bcmj.org]

Pesticide Unit, Epidemiological Studies Laboratory, California Department of Health, 2151 Berkeley Way, Berkeley, CA. 94704. Telephone: (415)-540-3063. [pmep.cce.cornell.edu]

Epidemiology of autistic disorder and other pervasive developmental disorders. J Clin Psychiatry. 2005; 10 :3–8. [ PubMed ] [ Google Scholar ] Handen BL. Johnson CR. McAuliffe-Bellin SJ. Hardan AO. [ncbi.nlm.nih.gov]

Abstract Several lines of evidence suggest that cholinergic deficits may contribute to the pathophysiology of psychiatric disorders as well as Alzheimer's disease. [ncbi.nlm.nih.gov]

[…] month after transplantation, the graft survival rate in Donepezil group was 46.7% than that in SHAM group (P Conclusions: Our results reveal that recipient treatment with Donepezil protects donor hearts through TNF inhibition and TNF related downstream pathophysiological [circ.ahajournals.org]

[…] odacheis Acetylcholinesterase inhibitor poisoning Organophosphate & Carbamate Insecticide Poisoning: Pathophysiology: Both organophosphate & carbamate insecticides are acetylcholinesterase inhibitors which are readily absorbed through intact skin or mucosa [ozemedicine.com]

Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology. Curr Pharm Des. 2010 Micheau J, Marighetto A. [nootriment.com]

Pathophysiology Acetylcholine (ACh) is a neurotransmitter found at both parasympathetic and sympathetic ganglia, skeletal neuromuscular junctions, terminal junctions of all postganglionic parasympathetic nerves, post-ganglionic sympathetic fibers to most [calpoison.org]

ACE inhibitor Any of a class of drugs that block the effects of angiotensin-converting enzyme, preventing the formation of angiotensin II and therefore preventing a rise in blood pressure. [medical-dictionary.thefreedictionary.com]

In contrast, ROS production and mitochondrial activity were totally prevented by addition of PMS777 but not galanthamine. PMS777 also inhibits butylcholinesterase and it shows selectivity for acetylcholinesterase. [ncbi.nlm.nih.gov]

These findings indicate that Lamiaceae species are a rich source of various natural AChE inhibitors and antioxidants that could be useful in the prevention and treatment of Alzheimer’s and other related diseases. [doi.org]