In the present study, we assessed a young child presenting with ichthyosis and hepatomegaly, suggesting a diagnosis of CDS. We identified an intronic mutation, c.960 + 5G>A, which was found to result in skipping of exon 6. [ncbi.nlm.nih.gov]

• Fatigue

  Body as a Whole: Hyperesthesia, paresthesias, arthralgia, progression of existing spinal hyperostosis, rigors, back pain, hypertonia, myalgia, fatigue, hot flashes, increased appetite. [robholland.com]

  Call your doctor immediately if you experience any of the following: Depression Suicidal thoughts Confusion Difficulty speaking Ear ringing Extreme fatigue Yellowing of the eyes or skin Vomiting Blurred vision Chest pains Slowed or irregular heartbeat [verywellhealth.com]

  Your pharmacist may be able to advise you on managing side effects. abdominal pain abnormal hair texture back pain change in appetite cold or clammy skin diarrhea dry eyes dry mouth, chapped lips (especially in the first few weeks) dry skin earache fatigue [uniprix.com]

  Adverse reactions CNS: headache, depression, insomnia, drowsiness, fatigue, migraine, rigors, abnormal gait, nerve inflammation, hyperesthesia, paresthesia, pseudotumor cerebri EENT: abnormal or blurred vision, dry eyes, eye irritation, eyebrow and eyelash [medical-dictionary.thefreedictionary.com]

• Asymptomatic

  These abnormalities were detected during routine screening for possible liver injury in an asymptomatic patient on acitretin. [livertox.nih.gov]

  The lesion was asymptomatic. Clinical examination revealed classic lacy white lesion involving lower lip. There were no skin lesions and systemic examination was within normal limit. [ijdd.in]

• Loss of Appetite

  Less frequent, but potentially serious side effects include: bad headaches, nausea, vomiting, blurred vision; decreased vision in the dark; depression; yellowing of your skin or the whites of your eyes, nausea and vomiting, loss of appetite or dark urine [tevagenerics.com]

  Tell your doctor immediately if you develop symptoms of liver problems, which may include: Nausea Vomiting Loss of appetite Pain in the upper right part of the stomach Yellowing of the skin or eyes Dark-colored urine Before taking acitretin, tell your [everydayhealth.com]

• Dysgeusia

  […] common (10% or more): Hyperesthesia (up to 25%), paresthesia (up to 25%) Common (1% to 10%): Headache, taste perversion Uncommon (0.1% to 1%): Dizziness, abnormal gait, migraine, neuritis, pseudotumor cerebri ( intracranial hypertension ), taste loss, dysgeusia [drugs.com]

  […] anorexia / Delayed / 1.0-10.0 infection / Delayed / 1.0-10.0 nausea / Early / 1.0-10.0 ocular pain / Early / 1.0-10.0 fatigue / Early / 1.0-10.0 appetite stimulation / Delayed / 1.0-10.0 diarrhea / Early / 1.0-10.0 abdominal pain / Early / 1.0-10.0 dysgeusia [pdr.net]

• Heart Disease

  RESULTS: A chart review of these patients revealed no X-ray-confirmed cases of DISH syndrome, minimal changes in coronary heart disease risk indicators, and extremely rare significant elevation of liver enzymes. [ncbi.nlm.nih.gov]

  Diabetes or high blood sugar Heart disease Spinal problems Liver disease Depression A stroke or mini-stroke Joint or bone disease Allergies to any medication Acitretin may affect your ability to see at night, and may also make your eyes dry. [everydayhealth.com]

  These tend to be more common in people with pre-existing illnesses such as heart disease, liver disease, kidney failure, diabetes, or psychiatric disorders. [verywellhealth.com]

  Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease liver disease heart disease diabetes personal or family history of mental/mood problems (such as depression) receive phototherapy Do not donate [myhealth.alberta.ca]

• Jaundice

  Physical examination was unrevealing and he had no apparent jaundice, rash, fever or signs of chronic liver disease. [livertox.nih.gov]

  […] eyes or mouth Itching, scaling or sticky feeling on skin Diarrhea Headaches Nausea Dizziness Weak or broken nails Hairloss Contact a doctor immediately should side effects persist or encounter more serious side effects such as: Mental or mood changes Jaundice [pharmacygeoff.md]

• Blurred Vision

  Blurred vision and decreased night vision may occur during treatment with this medicine. For this reason you are advised to be cautious when driving or operating any vehicle at night. [netdoctor.co.uk]

  Special Senses: Blurred vision, blepharitis, conjunctivitis, decreased night vision/night blindness, eye pain, photophobia; earache, tinnitus; taste perversion. Respiratory: Sinusitis. [robholland.com]

  Less frequent, but potentially serious side effects include: bad headaches, nausea, vomiting, blurred vision; decreased vision in the dark; depression; yellowing of your skin or the whites of your eyes, nausea and vomiting, loss of appetite or dark urine [tevagenerics.com]

  Other possible side effects include: Blurred vision and/or decreased night vision Muscle aches and joint pains or stiffness Hair loss – usually temporary and reversible when the medication is stopped Headaches. [dermcoll.edu.au]

• Eye Pain

  Special Senses: Blurred vision, blepharitis, conjunctivitis, decreased night vision/night blindness, eye pain, photophobia; earache, tinnitus; taste perversion. Respiratory: Sinusitis. [robholland.com]

  […] eyelid sensitivity of the eyes to light sore mouth or tongue thick, white vaginal discharge with no odor or with a mild odor watery eyes white patches in the mouth or on the tongue Rare Bleeding gums bleeding time increased chest pain coughing coughing [mayoclinic.org]

  eye irritation, intolerance of contact lenses Common (1% to 10%): Abnormal/ blurred vision, blepharitis, irritation, corneal epithelial abnormality, decreased night vision/night blindness, eye abnormality, eye pain, photophobia Uncommon (0.1% to 1%) [drugs.com]

  Stop taking SORIATANE and call your prescriber if you develop any vision problems or eye pain. abdominal pain, nausea, vomiting. These may be signs of pancreatitis (inflammation of the pancreas). bad headaches, nausea, vomiting, blurred vision. [soriatane.com]

• Arthralgia

  One patient discontinued treatment because of arthralgia. The remaining nine patients (50%) discontinued treatment because it was ineffective. Mucocutaneous adverse effects occurred in all patients, but did not affect therapy maintenance. [ncbi.nlm.nih.gov]

  […] plaque 57.79 38.09 13 748 1685 3383413 Cushing's syndrome 57.08 38.09 12 749 1134 3383964 Exposure via body fluid 55.33 38.09 10 751 428 3384670 Skin exfoliation 53.93 38.09 17 744 8020 3377078 Drug-induced liver injury 52.41 38.09 15 746 5098 3380000 Arthralgia [drugcentral.org]

  […] sticky skin, nail disorder, pruritus, dry mouth, rhinitis, hypervitaminosis A syndrome, epistaxis, rash, hyperesthesia, paresthesia, xerophthalmia, dry or irritated eye, loss of eye brow or lashes, decreased night vision, intolerance to contact lenses, arthralgia [empr.com]

  Body as a Whole: Hyperesthesia, paresthesias, arthralgia, progression of existing spinal hyperostosis, rigors, back pain, hypertonia, myalgia, fatigue, hot flashes, increased appetite. [robholland.com]

  Common side effects include: cheilitis, rhinitis, dry mouth, arthralgia, spinal hyperostosis, alopecia, skin peeling, dry skin, nail disorder, pruritus, erythematous rash, hyperesthesia, paresthesia, paronychia, skin atrophy, sticky skin, alteration in [tevagenerics.com]

• Otalgia

  […] appetite stimulation / Delayed / 1.0-10.0 diarrhea / Early / 1.0-10.0 abdominal pain / Early / 1.0-10.0 dysgeusia / Early / 1.0-10.0 back pain / Delayed / 1.0-10.0 myalgia / Early / 1.0-10.0 arthropathy / Delayed / 1.0-10.0 headache / Early / 1.0-10.0 otalgia [pdr.net]

• Alopecia

  Here we report a case of full body acitretin-induced poliosis with concurrent alopecia in a patient with psoriasis. A proposed mechanism for the poliosis is also presented here. [ncbi.nlm.nih.gov]

  A diagnosis of acitretin-induced alopecia with poliosis was made and acitretin was discontinued. [jddonline.com]

• Pruritus

  Lichen amyloidosus is a cutaneous dermatosis clinically characterized by an hyperkeratotic brownish-grey papular eruption located on trunk and extremities, associated to severe pruritus. [ncbi.nlm.nih.gov]

  In analysis 2, all adverse events were dose dependent except for pruritus, which occurred more frequently in the 25-mg group ( Figure 2 ); this apparent lack of dose dependency for pruritus was not seen in analysis 1. [jamanetwork.com]

• Dermatitis

  The safety and efficacy of acitretin in severe chronic hand dermatitis (CHD) is unknown. [ncbi.nlm.nih.gov]

  […] pain; arthritis; bone disorders; spinal bone overgrowth; increased muscle tone or rigidity; tendinitis Respiratory: coughing, increased sputum, laryngitis Skin: dry skin, pruritus, skin atrophy, skin peeling, abnormal skin odor, sticky skin, seborrhea, dermatitis [medical-dictionary.thefreedictionary.com]

• Skin Disease

  Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases. [ebi.ac.uk]

  He had no family history of skin disease. On physical examination, we observed circumscribed, reddish-orange, scaling plaques affecting the elbows and knees and a waxy palmoplantar keratoderma. [ncbi.nlm.nih.gov]

  Because of the long-term storage of etretinate, a known teratogen, fertile women who may be treated in this protocol, must have skin disease that is severe and recalcitrant to all other standard modalities. [clinicaltrials.gov]

• Skin Patch

  The first birth control method should include one of the following forms: birth control pills (but not the "mini-pill"); an intrauterine device (IUD); birth control shots, inserts, skin patches, or implants; a tubal ligation; or your male partner's vasectomy [uofmhealth.org]

  The first birth control method should include one of the following forms: birth control pills (but not the "mini-pill"), an intrauterine device (IUD), birth control shots, inserts, skin patches, or implants, a tubal ligation, or your male partner's vasectomy [cardiosmart.org]

• Withdrawn

  Description Synonyms all- trans Acitretin Ro 10-1670 Ro 10-1670/000 Acitretin is a second-generation retinoid that was introduced when etretinate (Item No. 19878 ) was withdrawn due to teratogenicity. [caymanchem.com]

  It is an active metabolite of the precursor drug, etretinate (Tegison, Hoffmann-La Roche, Nutley, NJ), which was widely used in the United States (U.S.) as a systemic psoriasis therapy until 1998 when it was withdrawn from the market and replaced by acitretin [jddonline.com]

  Of them, 25 patients (89.2%) finished the protocol and 3 patients (10.7%) were withdrawn before completion. Patients were administered 10 mg acitretin twice daily for 8 weeks. [ncbi.nlm.nih.gov]

  A similar pattern of acute liver injury was reported with etretinate, a related retinoid that was previously used for psoriasis and acne, but was withdrawn from use in the United States in 1998. [livertox.nih.gov]

  Affected organisms Humans and other mammals Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Drug Interactions All Drugs Approved Vet approved Nutraceutical Illicit Withdrawn Investigational Experimental Drug Interaction Unlock Additional [drugbank.ca]

• Aggressive Behavior

  Depression: This drug may cause depression or aggressive behavior, including self-harming urges. Call a doctor right away if these urges occur. The doctor may recommend a medication change. [medicalnewstoday.com]

  Depression and/or other psychiatric symptoms such as aggressive behavior or thoughts of self-harm have been reported during acitretin therapy. [pdr.net]

• Dark Urine

  urine (pee), and light stools) Bone formation within tendons Stop the medicine and call your doctor if you have any of the above symptoms. [uihc.org]

  Less frequent, but potentially serious side effects include: bad headaches, nausea, vomiting, blurred vision; decreased vision in the dark; depression; yellowing of your skin or the whites of your eyes, nausea and vomiting, loss of appetite or dark urine [tevagenerics.com]

• Headache

  Clinically pseudotumor cerebri presents with headache, diplopia, nausea, vomiting, papilloedema and if treatment is delayed, may lead to blindness. [ncbi.nlm.nih.gov]

  Other possible side effects include: Blurred vision and/or decreased night vision Muscle aches and joint pains or stiffness Hair loss – usually temporary and reversible when the medication is stopped Headaches. [dermcoll.edu.au]

  problems with speech or balance, swelling or warmth in one or both legs; high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision; increased pressure inside the skull --severe headaches, ringing [uofmhealth.org]

• Seizure

  Call your doctor right away if you have a bad headache, dizziness, upset stomach or throwing up, or seizures. [drugs.com]

  If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. [medlineplus.gov]

• Asthenia

  […] cutaneous fragility and more alopecia. 23 Non-randomized studies have suggested that vitamin E supplementation, at a daily dose of 800 IU, can relieve some of the mucocutaneous effects of the retinoids. 10 Other effects that have been reported are: asthenia [scielo.br]

Monitoring Prior to starting a patient on acitretin, obtain a medical history and perform a baseline workup, including baseline liver function tests and lipid panel ( Table 2 ). [the-dermatologist.com]

• Glucose Increased

  […] risk of hypertriglyceridemia in patients with diabetes mellitus, obesity, increased alcohol intake, lipid metabolism disorder, or familial history of these conditions. 1 6 7 8 9 19 Close monitoring of serum lipid and/or glucose in these patients and [drugs.com]

• Staphylococcus Aureus

  Skin infections, especially with Staphylococcus aureus ( impetigo, boils or nail fold paronychia ). [dermnetnz.org]

The oral acitretin treatment is efficient in severe congenital ichthyosis. [ncbi.nlm.nih.gov]

Acitretin Chemical Properties,Uses,Production Description Acitretin is the free acid form of etretinate useful in the treatment of severe psoriasis and other disorders of keratinization. [chemicalbook.com]

The exact etiology of PPPK has not been fully understood. Furthermore, no standardized treatment for PPPK has been established and treatment options are limited. [ncbi.nlm.nih.gov]

Evaluate human papillomavirus (HPV) as a possible etiologic cofactor in the development of cutaneous epidermal dysplasia/carcinoma from skin tissues of these patients. [clinicaltrials.gov]

Among the many etiologic mechanisms proposed dermal T-lymphocyte mediated autoimmunity is considered most likely. These cells after activation produce cytokines such as interferon-α. [ijdd.in]

If hepatotoxicity is suspected, discontinue acitretin and investigate the etiology. [pdr.net]

ABSTRACT:Background: Studies have identified numerous genetic polymorphisms associat... more Skin Cancer Epidemiology and Sun Protection Behaviors Among Native American.... [jddonline.com]

Strict pregnancy prevention is required in women of childbearing potential who use acitretin. [ncbi.nlm.nih.gov]

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of acitretin may be an effective way to prevent the recurrence or further development of skin cancer. [clinicaltrials.gov]

It is recommended that the patient either abstain from sexual intercourse or use 2 reliable kinds of birth control at the same time to prevent unwanted pregnancy. [pdr.net]