In the present study, we assessed a young child presenting with ichthyosis and hepatomegaly, suggesting a diagnosis of CDS. We identified an intronic mutation, c.960 5G A, which was found to result in skipping of exon 6. [ncbi.nlm.nih.gov]

• Fatigue

  Body as a Whole: Hyperesthesia, paresthesias, arthralgia, progression of existing spinal hyperostosis, rigors, back pain, hypertonia, myalgia, fatigue, hot flashes, increased appetite. [robholland.com]

  Adverse reactions CNS: headache, depression, insomnia, drowsiness, fatigue, migraine, rigors, abnormal gait, nerve inflammation, hyperesthesia, paresthesia, pseudotumor cerebri EENT: abnormal or blurred vision, dry eyes, eye irritation, eyebrow and eyelash [medical-dictionary.thefreedictionary.com]

  Call your doctor immediately if you experience any of the following: Depression Suicidal thoughts Confusion Difficulty speaking Ear ringing Extreme fatigue Yellowing of the eyes or skin Vomiting Blurred vision Chest pains Slowed or irregular heartbeat [verywellhealth.com]

  Your pharmacist may be able to advise you on managing side effects. abdominal pain abnormal hair texture back pain change in appetite cold or clammy skin diarrhea dry eyes dry mouth, chapped lips (especially in the first few weeks) dry skin earache fatigue [uniprix.com]

• Turkish

  In this report, we describe the clinicopathological and genetic features of a Turkish LP family with four cases, and evaluate the response of acitretin therapy. [ncbi.nlm.nih.gov]

• Lymphedema

  Elephantiasis nostras verrucosa is a rare disorder characterized by dermal fibrosis, hyperkeratotic, verrucous, and papillomatous lesions that result from both chronic filarial and nonfilarial lymphedema. [ncbi.nlm.nih.gov]

• Inguinal Lesions

  The patient was treated with oral acitretin for 1 year (with a topical corticosteroid for the inguinal lesions), resulting in clearing of the cutaneous lesions. [ncbi.nlm.nih.gov]

• Arachnodactyly

  Here, we present two cases of same family with HMS having all the cardinal features of HMS which includes palmo plantar keratoderma and periodontitis along with arachnodactyly, acroosteolysis, onychogryphosis, and marked osteopenia on hand wrist radiographs [ncbi.nlm.nih.gov]

• Periodontitis

  Treatment with acitretin resulted in excellent improvement of periodontitis, increase in the alveolar bone height, and periodontal attachment. Improvement remained stable at the end of 1-year follow-up. [ncbi.nlm.nih.gov]

• Hepatomegaly

  The authors herein report an 18-month-old boy with ichthyosis and hepatomegaly diagnosed with CDS and confirmed to have a novel c.506-3C G mutation in the ABHD5/CGI-58 gene. [ncbi.nlm.nih.gov]

• Otalgia

  […] appetite stimulation / Delayed / 1.0-10.0 diarrhea / Early / 1.0-10.0 abdominal pain / Early / 1.0-10.0 dysgeusia / Early / 1.0-10.0 back pain / Delayed / 1.0-10.0 myalgia / Early / 1.0-10.0 arthropathy / Delayed / 1.0-10.0 headache / Early / 1.0-10.0 otalgia [pdr.net]

• Alopecia

  Here we report a case of full body acitretin-induced poliosis with concurrent alopecia in a patient with psoriasis. A proposed mechanism for the poliosis is also presented here. [ncbi.nlm.nih.gov]

  Five patients discontinued therapy because of adverse, generally mild events that included xerosis/skin peeling (22%), chelitis (13%), dyslipidemia (13%), alopecia (9%) and depression (9%). [healio.com]

• Eczema

  Alitretinoin and acitretin are effective treatment options for patients with hand eczema. However, both treatments were more effective in patients with hyperkeratotic hand eczema. [ncbi.nlm.nih.gov]

  Rosacea, Acne, Shingles: Common Adult Skin Diseases Learn to spot and treat skin conditions commonly found in adults such as acne, eczema, shingles, psoriasis, rosacea, hives, cold... [medicinenet.com]

  Alitretinoin used for hand eczema is classified in D11A. ATC code Name DDD U Adm.R Note D05BB02 acitretin 35 mg O List of abbreviations Last updated: 2018-12-13 [whocc.no]

• Skin Rash

  Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives. Neotigason is not always suitable for all patients. [pharmacygeoff.md]

  Check with your doctor right away if you are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash [mayoclinic.org]

• Arthralgia

  One patient discontinued treatment because of arthralgia. The remaining nine patients (50%) discontinued treatment because it was ineffective. Mucocutaneous adverse effects occurred in all patients, but did not affect therapy maintenance. [ncbi.nlm.nih.gov]

  Body as a Whole: Hyperesthesia, paresthesias, arthralgia, progression of existing spinal hyperostosis, rigors, back pain, hypertonia, myalgia, fatigue, hot flashes, increased appetite. [robholland.com]

  Common side effects include: cheilitis, rhinitis, dry mouth, arthralgia, spinal hyperostosis, alopecia, skin peeling, dry skin, nail disorder, pruritus, erythematous rash, hyperesthesia, paresthesia, paronychia, skin atrophy, sticky skin, alteration in [tevagenerics.com]

  […] plaque 57.79 38.09 13 748 1685 3383413 Cushing's syndrome 57.08 38.09 12 749 1134 3383964 Exposure via body fluid 55.33 38.09 10 751 428 3384670 Skin exfoliation 53.93 38.09 17 744 8020 3377078 Drug-induced liver injury 52.41 38.09 15 746 5098 3380000 Arthralgia [drugcentral.org]

  Musculo-skeletal system: Myalgia and arthralgia may occur and be associated with reduced tolerance to exercise. Bone pain has also been reported. [papaa.org]

• Sexual Dysfunction

  When LP involves the genitalia it may present as painful, pruritic erosions that can be exquisitely tender, causing distress and genitourinary and sexual dysfunction. Management of erosive genital LP is often suboptimal. [ncbi.nlm.nih.gov]

• Headache

  Clinically pseudotumor cerebri presents with headache, diplopia, nausea, vomiting, papilloedema and if treatment is delayed, may lead to blindness. [ncbi.nlm.nih.gov]

  In addition, it may cause nausea, headache, itching, dry, red or flaky skin, dry or red eyes, dry or chapped lips, swollen lips, dry mouth, thirst, cystic acne or hair loss. [2] [3] [4] Pharmacokinetics [ edit ] It is a metabolite of etretinate, which [en.wikipedia.org]

  problems with speech or balance, swelling or warmth in one or both legs; high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision; increased pressure inside the skull --severe headaches, ringing [emedicinehealth.com]

  Alcohol use: interference with acitretin elimination, possible drug toxicity Patient monitoring • Monitor patient who has early signs or symptoms of pseudotumor cerebri, such as headache, nausea, vomiting, and visual disturbances. [medical-dictionary.thefreedictionary.com]

• Responsiveness Decreasing

  decreases polymorphonuclear leukocyte migration/accumulation; and increases the number of Langerhans cells in normal and psoriatic skin. 4 6 8 9 17 19 Exhibits antineoplastic activity in vitro. 17 Has teratogenic effects. 1 (See Boxed Warning.) [drugs.com]

Monitoring Prior to starting a patient on acitretin, obtain a medical history and perform a baseline workup, including baseline liver function tests and lipid panel ( Table 2 ). [the-dermatologist.com]

OBJECTIVE: To evaluate the efficacy of NB-UVB, Goeckerman therapy and the effect of addition of retinoid to the treatment regimen in the treatment of psoriasis,. [ncbi.nlm.nih.gov]

The exact etiology of PPPK has not been fully understood. Furthermore, no standardized treatment for PPPK has been established and treatment options are limited. [ncbi.nlm.nih.gov]

Evaluate human papillomavirus (HPV) as a possible etiologic cofactor in the development of cutaneous epidermal dysplasia/carcinoma from skin tissues of these patients. [clinicaltrials.gov]

Among the many etiologic mechanisms proposed dermal T-lymphocyte mediated autoimmunity is considered most likely. These cells after activation produce cytokines such as interferon-α. [ijdd.in]

If hepatotoxicity is suspected, discontinue acitretin and investigate the etiology. [pdr.net]

ABSTRACT:Background: Studies have identified numerous genetic polymorphisms associat... more Skin Cancer Epidemiology and Sun Protection Behaviors Among Native American.... [jddonline.com]

Strict pregnancy prevention is required in women of childbearing potential who use acitretin. [ncbi.nlm.nih.gov]