Presentation
In the present study, we assessed a young child presenting with ichthyosis and hepatomegaly, suggesting a diagnosis of CDS. We identified an intronic mutation, c.960 + 5G>A, which was found to result in skipping of exon 6. [ncbi.nlm.nih.gov]
Entire Body System
- Fatigue
Body as a Whole: Hyperesthesia, paresthesias, arthralgia, progression of existing spinal hyperostosis, rigors, back pain, hypertonia, myalgia, fatigue, hot flashes, increased appetite. [robholland.com]
Call your doctor immediately if you experience any of the following: Depression Suicidal thoughts Confusion Difficulty speaking Ear ringing Extreme fatigue Yellowing of the eyes or skin Vomiting Blurred vision Chest pains Slowed or irregular heartbeat [verywellhealth.com]
Your pharmacist may be able to advise you on managing side effects. abdominal pain abnormal hair texture back pain change in appetite cold or clammy skin diarrhea dry eyes dry mouth, chapped lips (especially in the first few weeks) dry skin earache fatigue [uniprix.com]
Adverse reactions CNS: headache, depression, insomnia, drowsiness, fatigue, migraine, rigors, abnormal gait, nerve inflammation, hyperesthesia, paresthesia, pseudotumor cerebri EENT: abnormal or blurred vision, dry eyes, eye irritation, eyebrow and eyelash [medical-dictionary.thefreedictionary.com]
Respiratoric
- Cough
coughing up blood darkened urine diarrhea difficulty in breathing or swallowing double vision or other problems in seeing, including decreased night vision after sunset and before sunrise hoarseness increased menstrual flow or vaginal bleeding itchy [mayoclinic.org]
coughing up blood, sweating, or passing out) signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating) signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing [uniprix.com]
abnormal hepatic function, jaundice, hepatitis Metabolic: poor blood glucose control Musculoskeletal: joint, muscle, back, and bone pain; arthritis; bone disorders; spinal bone overgrowth; increased muscle tone or rigidity; tendinitis Respiratory: coughing [medical-dictionary.thefreedictionary.com]
Gastrointestinal
- Nausea
Clinically pseudotumor cerebri presents with headache, diplopia, nausea, vomiting, papilloedema and if treatment is delayed, may lead to blindness. [ncbi.nlm.nih.gov]
Stop taking SORIATANE and call your prescriber if you develop any vision problems or eye pain. abdominal pain, nausea, vomiting. These may be signs of pancreatitis (inflammation of the pancreas). bad headaches, nausea, vomiting, blurred vision. [soriatane.com]
Contact your doctor if you experience headaches, nausea and vomiting, or changes in vision. [uniprix.com]
Less frequent, but potentially serious side effects include: bad headaches, nausea, vomiting, blurred vision; decreased vision in the dark; depression; yellowing of your skin or the whites of your eyes, nausea and vomiting, loss of appetite or dark urine [tevagenerics.com]
Call your doctor right away if you have a fever, cloudy urine, decrease or increase in the amount of urine, fainting or lightheadedness, nausea, stomach pain, or swelling of hands, ankles, feet, or lower legs. [mayoclinic.org]
- Vomiting
Vomiting (throwing up) Blurry vision Decreased night vision Depression Liver damage (which can cause yellow skin, yellow eyes, vomiting, dark urine (pee), and light stools) Bone formation within tendons Stop the medicine and call your doctor if you [uihc.org]
Clinically pseudotumor cerebri presents with headache, diplopia, nausea, vomiting, papilloedema and if treatment is delayed, may lead to blindness. [ncbi.nlm.nih.gov]
Less frequent, but potentially serious side effects include: bad headaches, nausea, vomiting, blurred vision; decreased vision in the dark; depression; yellowing of your skin or the whites of your eyes, nausea and vomiting, loss of appetite or dark urine [tevagenerics.com]
Stop taking SORIATANE and call your prescriber if you develop any vision problems or eye pain. abdominal pain, nausea, vomiting. These may be signs of pancreatitis (inflammation of the pancreas). bad headaches, nausea, vomiting, blurred vision. [soriatane.com]
Dry nose and nose bleeds Nausea, vomiting, abdominal pain and heartburn. [dermcoll.edu.au]
Liver, Gall & Pancreas
- Jaundice
Physical examination was unrevealing and he had no apparent jaundice, rash, fever or signs of chronic liver disease. [livertox.nih.gov]
[…] eyes or mouth Itching, scaling or sticky feeling on skin Diarrhea Headaches Nausea Dizziness Weak or broken nails Hairloss Contact a doctor immediately should side effects persist or encounter more serious side effects such as: Mental or mood changes Jaundice [pharmacygeoff.md]
Stop taking this medicine and call your doctor right away if you have symptoms such as nausea, vomiting, loss of appetite, dark urine, or jaundice (yellowing of your skin or eyes). [drugs.com]
Cardiovascular
- Hypertension
Its mucocutaneous and ocular adverse reactions are common or relatively common, whereas systemic side effects are either uncommon or rare and include teratogenesis, hyperlipidemia, hepatotoxicity, intracranial hypertension, myopathy, and peripheral neuropathy [ncbi.nlm.nih.gov]
Combination of acitretin with potentially hepatotoxic molecules (methotrexate) is contraindicated, as is combination with cyclines (risk of intracranial hypertension). Similar articles Acitretin : A Review of its Pharmacology and Therapeutic Use. [pubmed.ncbi.nlm.nih.gov]
Hypercholesterolemia contraindication 13644009 Depressive disorder contraindication 35489007 DOID:2848 Acute nephropathy contraindication 58574008 Hepatic failure contraindication 59927004 Night blindness contraindication 65194006 DOID:8499 Benign intracranial hypertension [drugcentral.org]
Raised pressure inside the skull (benign intracranial hypertension). [netdoctor.co.uk]
Jaw & Teeth
- Cheilitis
Several side effects of acitretin have been reported such as teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity. Many drugs, mainly antibiotics and nonsteroidal anti-inflammatory drugs, can cause angioedema-urticaria. [ncbi.nlm.nih.gov]
Several side effects of acitretin have been reported such as teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity. Many drugs, mainly antibiotics and nonsteroidal anti-inflammatory drugs, can cause angioedema – urticaria. [journals.lww.com]
- Cracked Lips
What to expect when using acitretin and potential side effects Acitretin commonly causes dry, cracked lips and skin. A lip balm and moisturiser is recommended during treatment. Peeling and redness of the skin is common. Acitretin may cause dry eyes. [dermcoll.edu.au]
Dry or cracked lips. Hair thinning and hair loss (alopecia). If this occurs it will usually happen four to eight weeks after starting treatment, and is reversible after the medicine is stopped. [netdoctor.co.uk]
Musculoskeletal
- Arthralgia
One patient discontinued treatment because of arthralgia. The remaining nine patients (50%) discontinued treatment because it was ineffective. Mucocutaneous adverse effects occurred in all patients, but did not affect therapy maintenance. [ncbi.nlm.nih.gov]
[…] plaque 57.79 38.09 13 748 1685 3383413 Cushing's syndrome 57.08 38.09 12 749 1134 3383964 Exposure via body fluid 55.33 38.09 10 751 428 3384670 Skin exfoliation 53.93 38.09 17 744 8020 3377078 Drug-induced liver injury 52.41 38.09 15 746 5098 3380000 Arthralgia [drugcentral.org]
[…] sticky skin, nail disorder, pruritus, dry mouth, rhinitis, hypervitaminosis A syndrome, epistaxis, rash, hyperesthesia, paresthesia, xerophthalmia, dry or irritated eye, loss of eye brow or lashes, decreased night vision, intolerance to contact lenses, arthralgia [empr.com]
Body as a Whole: Hyperesthesia, paresthesias, arthralgia, progression of existing spinal hyperostosis, rigors, back pain, hypertonia, myalgia, fatigue, hot flashes, increased appetite. [robholland.com]
Common side effects include: cheilitis, rhinitis, dry mouth, arthralgia, spinal hyperostosis, alopecia, skin peeling, dry skin, nail disorder, pruritus, erythematous rash, hyperesthesia, paresthesia, paronychia, skin atrophy, sticky skin, alteration in [tevagenerics.com]
- Osteoporosis
Bony changes (ligament calcifications, osteoporosis) have been reported with various incidence. In children, growth and development have to be monitored. [pubmed.ncbi.nlm.nih.gov]
Parkinson) contraindication to acitretin such as osteoporosis, hypoalbuminaemia Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided [clinicaltrials.gov]
Hyperlipidemia, diabetes mellitus and osteoporosis are relative contraindications. [scielo.br]
Ears
Skin
- Alopecia
Here we report a case of full body acitretin-induced poliosis with concurrent alopecia in a patient with psoriasis. A proposed mechanism for the poliosis is also presented here. [ncbi.nlm.nih.gov]
A diagnosis of acitretin-induced alopecia with poliosis was made and acitretin was discontinued. [jddonline.com]
- Hyperkeratosis
Spiny follicular hyperkeratosis (SFH) is follicular flesh-colored hyperkeratotic spicules that are linked to different situations including drug reactions. Previously suspected drugs are BRAF inhibitors and cyclosporine. [ncbi.nlm.nih.gov]
Pretreatment skin punch biopsy revealed a moderate degree of hyperkeratosis with complete absence of granular cell layer in the epidermis. Hyperkeratosis extended into the hair follicles forming keratotic follicular plugs. [ispub.com]
Severe forms of disorders of keratinisation such as: hyperkeratosis palmaris et plantaris; pustulosis palmaris et plantaris; ichthyosis; keratosis follicularis (Darier's disease); lichen planus affecting the skin or the mucosae; pityriasis rubra pilaris [healthdirect.gov.au]
- Keratosis
There are fewer than 20 reported cases of pediatric-onset keratosis lichenoides chronica in the current literature, with occurrence of pseudoepitheliomatous hyperplasia of primary keratosis lichenoides chronica lesions being even rarer. [ncbi.nlm.nih.gov]
Severe forms of disorders of keratinisation such as: hyperkeratosis palmaris et plantaris; pustulosis palmaris et plantaris; ichthyosis; keratosis follicularis (Darier's disease); lichen planus affecting the skin or the mucosae; pityriasis rubra pilaris [healthdirect.gov.au]
Off-label uses • Darier's disease (keratosis follicularis) • Lamellar ichthyosis (in children) • Lichen planus • Nonbullous and bullous ichthyosiform erythroderma • Palmoplantar pustulosis • Sjögren-Larsson syndrome Contraindications • Hypersensitivity [medical-dictionary.thefreedictionary.com]
- Eczema
Alitretinoin and acitretin are effective treatment options for patients with hand eczema. However, both treatments were more effective in patients with hyperkeratotic hand eczema. [ncbi.nlm.nih.gov]
Alitretinoin used for hand eczema is classified in D11A. ATC code Name DDD U Adm.R Note D05BB02 acitretin 35 mg O List of abbreviations Last updated: 2018-12-13 [whocc.no]
Rosacea, Acne, Shingles: Common Adult Skin Diseases Learn to spot and treat skin conditions commonly found in adults such as acne, eczema, shingles, psoriasis, rosacea, hives, cold... [medicinenet.com]
- Skin Rash
Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives. Neotigason is not always suitable for all patients. [pharmacygeoff.md]
Check with your doctor right away if you are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash [mayoclinic.org]
Neurologic
- Headache
Clinically pseudotumor cerebri presents with headache, diplopia, nausea, vomiting, papilloedema and if treatment is delayed, may lead to blindness. [ncbi.nlm.nih.gov]
Other possible side effects include: Blurred vision and/or decreased night vision Muscle aches and joint pains or stiffness Hair loss – usually temporary and reversible when the medication is stopped Headaches. [dermcoll.edu.au]
problems with speech or balance, swelling or warmth in one or both legs; high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision; increased pressure inside the skull --severe headaches, ringing [mottchildren.org]
Workup
Monitoring Prior to starting a patient on acitretin, obtain a medical history and perform a baseline workup, including baseline liver function tests and lipid panel ( Table 2 ). [the-dermatologist.com]
Treatment
The oral acitretin treatment is efficient in severe congenital ichthyosis. [ncbi.nlm.nih.gov]
Acitretin Chemical Properties,Uses,Production Description Acitretin is the free acid form of etretinate useful in the treatment of severe psoriasis and other disorders of keratinization. [chemicalbook.com]
Etiology
The exact etiology of PPPK has not been fully understood. Furthermore, no standardized treatment for PPPK has been established and treatment options are limited. [ncbi.nlm.nih.gov]
Evaluate human papillomavirus (HPV) as a possible etiologic cofactor in the development of cutaneous epidermal dysplasia/carcinoma from skin tissues of these patients. [clinicaltrials.gov]
Among the many etiologic mechanisms proposed dermal T-lymphocyte mediated autoimmunity is considered most likely. These cells after activation produce cytokines such as interferon-α. [ijdd.in]
If hepatotoxicity is suspected, discontinue acitretin and investigate the etiology. [pdr.net]
Epidemiology
ABSTRACT:Background: Studies have identified numerous genetic polymorphisms associat... more Skin Cancer Epidemiology and Sun Protection Behaviors Among Native American.... [jddonline.com]
Prevention
Strict pregnancy prevention is required in women of childbearing potential who use acitretin. [ncbi.nlm.nih.gov]
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of acitretin may be an effective way to prevent the recurrence or further development of skin cancer. [clinicaltrials.gov]
It is recommended that the patient either abstain from sexual intercourse or use 2 reliable kinds of birth control at the same time to prevent unwanted pregnancy. [pdr.net]