A skin biopsy of the axillary lesion demonstrated fragmentation of elastic fibers, but with a negative von Kossa stain, consistent with cutis laxa. [ncbi.nlm.nih.gov]

The skin laxity was preceded by swelling of the fingers and toes and by the appearance of papular urticaria. Dapsone therapy was effective in controlling the swelling. [ncbi.nlm.nih.gov]

This case presents a plethora of cutaneous findings (primary systemic amyloidosis, acquired cutis laxa and mucinosis), all linked to MM. There is not, at present, another description of all these findings on the same patient. REFERENCES 1. [scielo.br]

There were no constitutional symptoms and the urticaria was not associated with any specific food or drug intake. [ijdvl.com]

Beyond its usefulness to general pathologists, dermatopathologists, and hematopathologists, this information is intended to be helpful for dermatologists, hematologists/oncologists, fellows, and residents. [books.google.com]

bites, or drug intake, such as penicillin or penicillamine. [jle.com]

bite, following drug intake or a malignancy. [e-ijd.org]

Type 1 acquired cutis laxa can be either generalized or localized may occur at any age, though the usual onset is in adulthood, usually follows episodes of inflammatory dermatosis, hypersensitivity reaction to insect bite or drugs such as penicillin, [ijpd.in]

bites and related to an underlying hematologic disorder (ie, multiple myeloma, lymphoma, immunoglobulin heavy-chain deposition disease, plasma cell dyscrasia). 1 - 4 Acquired cutis laxa has also been reported in patients following cutaneous mastocytosis [jamanetwork.com]

The primary clinical manifestation was an erythema of the chest. Gradually there developed persistent circumscribed lesions in other areas of the skin, spreading into large erythematous plaques with loose skin. [ncbi.nlm.nih.gov]

In the last four years, the patient reports pain and paresthesia in a stocking-like pattern affecting the lower limbs. The patient denied any familial history of cutaneous lesions. [scielo.br]