During childhood, those living with CGL have large appetites, accelerated growth in height, and advanced bone age. [psychneuro.wordpress.com]

During childhood, affected individuals are described as being voracious eaters and may experience accelerated growth. Affected individuals may also experience fatigue. [rarediseases.org]

Hepatosplenomegaly, umbilical prominence or hernia, acanthosis nigricans, voracious appetite and accelerated growth can occur. Female patients develop hirsutism, may have clitoromegaly, oligomenorrhea and polycystic ovaries. [intechopen.com]

She had coarse facial features with generalized loss of subcutaneous fat and prominent muscularity. Remarkable acanthosis nigricans was present over the neck, axilla, and umbilicus. [ncbi.nlm.nih.gov]

Increased fat cell size may represent the failure of the adipose tissue mass to expand and thus to accommodate an increased energy influx. [scienceopen.com]

We present the case of a 78-year-old woman who experienced almost complete loss of subcutaneous adipose tissue over 6 years. [ncbi.nlm.nih.gov]

Elsevier Health Sciences, ٢٥‏/٠٢‏/٢٠١٥ - 2700 من الصفحات Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology [books.google.com]

Hypermetabolism is an important feature and is associated with increased appetite; there is ingestion of large amounts of calories and profuse sweating. There may be hyperthermia. [ijdvl.com]

[…] of subcutaneous fat and the presence of muscle hypertrophy, hyperlipemia, diabetes mellitus, and hepatosplenomegaly with cirrhosis. [epathologies.com]

Case Reports Case 1 A 13-month-old female child, born out of nonconsanguineous marriage, was brought to our department with complaints of abnormal facial features, almost complete generalized absence of subcutaneous fat, muscular hypertrophy, generalized [ijpd.in]

The physical appearance of patients with familial and acquired PL may be more difficult to discern compared with generalized lipodystrophy (GL) where patients have a stark absence of subcutaneous fat (Figure 1) [ 2 ]. [omicsonline.org]

Therefore, novel CGL genes may be identified in the future. 23 The most striking clinical manifestations of CGL are abnormal appearance due to the absence of subcutaneous fat in the abdomen and thorax, which becomes evident within the first 2 years of [dovepress.com]

Case 3 is an 11-year-old boy with active autoimmune hepatitis and chronic urticaria, whose hyperphagia has resolved and his liver enzymes and hepatosplenomegaly have improved. [ncbi.nlm.nih.gov]

AGL case 3 (AGL-3) AGL-3 is an 11-year-old boy with AGL and autoimmune hepatitis, chronic urticaria, and IgA deficiency. [academic.oup.com]