Edit concept Question Editor Create issue ticket

Acquired Megacolon

Megacolon Acquired Organic


Presentation

  • A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories.[books.google.com]
  • The aims of the present study were to assess the distribution of ICC and neuronal cells of ENS in patients with slow-transit constipation and acquired megacolon.[ncbi.nlm.nih.gov]
  • […] doi: 10.1007/BF02616842 Acquired megacolon in Chagas' disease: PDF Only Abstract Article Metrics Metrics Summary and Conclusions Summary and ConclusionsIn this excellent presentation, a report is made of the well-established role of T. cruzi in the etiology[journals.lww.com]
  • Superbly presented with line drawings, high quality radiographic images and colour photographs. Presented in similar form to its sister textbook Davidson’s Principles and Practice of Medicine.[books.google.de]
Gangrene
  • Bowel gangrene results following ischaemic tissue death of the strangulated bowel tissue if the condition is left untreated. This in turn results in peritonitis and possible generalised sepsis.[gpnotebook.co.uk]
Whipple Disease
  • Traveler s diarrhea Classification and external resources ICD 9 009.2 Traveler s diarrhea (TD), is the most common illness affecting travelers … Wikipedia Whipple's disease — Classification and external resources Low magnification micrograph of Whipple[medicine.academic.ru]
Constipation
  • CONCLUSIONS: Slow-transit constipation and acquired megacolon were associated with alteration of ICC and neuronal cells of ENS in the sigmoid colon.[ncbi.nlm.nih.gov]
  • Forty-eight patients treated for chronic incapacitating constipation by surgical resection were reviewed.[experts.umn.edu]
  • Extra-large enemas, rather than treating chronic constipation, can actually exacerbate chronic constipation as reported by this Doctor:- One of my cases was chronically constipated at the age of 38.[zity.biz]
  • Result from infection or chronic constipation. Infection with the protozoan Trypanosoma cruzi(Chagas' disease) destroys ganglion cells and produces both megacolon and megaesophagus. b.[gradestack.com]
Abdominal Distension
  • A 61-year-old male, with long-standing abdominal distension, presented with generalised abdominal pain, shortness of breath, and marked abdominal distension.[nzma.org.nz]
  • […] pass either flatus or stool. [ 4 ] It may present insidiously with chronic abdominal distension, constipation, vague and usually colicky lower abdominal discomfort and vomiting.[patient.info]
  • The abdominal distension soon after birth in cases of megacolon is a manifestation of a disease picture resembling ileus and does not prove the congenital dilatation of the colon b) The significance attributed to colonic redundancy is based on insufficient[onlinelibrary.wiley.com]
  • Case Report A 76-year-old woman admitted to surgery division of our hospital with chronic abdominal pain, abdominal distension, and constipation lasting for 10 days.[ispub.com]
Tenesmus
  • Signs : lethargy, anorexia, constipation, ptyalism, vomiting, tenesmus. Diagnosis : abdominal palpation, confirmed by abdominal radiographs.[vetstream.com]
Gastropathy
  • […] stricture · Megaesophagus Stomach Gastritis ( Atrophic, Ménétrier's disease, Gastroenteritis ) · Peptic (gastric) ulcer ( Cushing ulcer, Dieulafoy's lesion ) · Dyspepsia · Pyloric stenosis · Achlorhydria · Gastroparesis · Gastroptosis · Portal hypertensive gastropathy[dictionnaire.sensagent.leparisien.fr]
Suggestibility
  • The origin of altered neuropeptide levels is unknown, but recent work suggested that tissue antioxidants may function as neuroprotectants.[ncbi.nlm.nih.gov]
  • Evidence suggests that excessive production of nitric oxide may be the mechanism for toxic megacolon in ulcerative colitis; as yet, there is no evidence for a possible role of nitric oxide in chronic megacolon unrelated to inflammatory bowel disease.[emedicine.medscape.com]
  • […] who gave me a full physical, ordered more enemas, and sent me to another specialist, who after examining me and looking at some new X-rays, told me again of my long colon and very deep pockets, and told me I had to have a lot of very high enemas, and suggested[zity.biz]
Incontinence
  • Keywords Fecal Incontinence Internal Anal Sphincter Megacolon Peritoneal Reflection Rectal Stump These keywords were added by machine and not by the authors.[link.springer.com]
Lethargy
  • Signs : lethargy, anorexia, constipation, ptyalism, vomiting, tenesmus. Diagnosis : abdominal palpation, confirmed by abdominal radiographs.[vetstream.com]
Excitement
  • Pathogenesis Etiology Often idiopathic - dysfunction of colonic smooth muscle, progressive post-receptor defect in excitation-contraction coupling. Secondary to colonic obstruction: Extraluminal compression, eg pelvic fracture.[vetstream.com]

Treatment

  • In: Treatment of acquired megacolon in the dog and cat. JAVMA 188 , 1412-1416.[vetstream.com]
  • Simpson: Neonatal Hirschsprung’s disease: Treatment of complete anganglionosis of the colon by the Duhamel operation. Arch. Surg. 87 : 1019, 1963. PubMed Google Scholar 6.[link.springer.com]
  • Learn about this topic in these articles: causes, symptoms, and treatment In megacolon …megacolon, or Hirschsprung disease, and acquired megacolon.[britannica.com]
  • The actual aim of treatment is correction or palliation of obstipation and although results proved to be good in about 70 per cent of traced patients, the chances of recurrence cannot be predicted because neuronal destruction in the remainder of the intestine[journals.lww.com]
  • Most cases respond to medical treatment. Advanced cases of megacolon and megarectum can be treated surgically by Duhamel technique.[jcol.elsevier.es]

Prognosis

  • Links: pathophysiology clinical features investigation management prognosis[gpnotebook.co.uk]
  • Prognosis : guarded depending on stage of disease and choice of treatment. Pathogenesis Etiology Often idiopathic - dysfunction of colonic smooth muscle, progressive post-receptor defect in excitation-contraction coupling.[vetstream.com]
  • Definitive pathophysiology, prognosis, treatment and management of both conditions remain largely unknown; hence, further research is necessary. This study will investigate these conditions during colonoscopy to identify disease specific features.[researchweb.org]
  • Prognosis The overall mortality in recent studies is less than 5%. [ 1 ] However, the reported mortality rates in some studies are as high as 20-25%, depending on the interval between diagnosis and treatment.[patient.info]
  • Further prognosis determined by the form and causes of megacolon, the correctness of the amount and method of operation.[medicalformat.com]

Etiology

  • […] doi: 10.1007/BF02616842 Acquired megacolon in Chagas' disease: PDF Only Abstract Article Metrics Metrics Summary and Conclusions Summary and ConclusionsIn this excellent presentation, a report is made of the well-established role of T. cruzi in the etiology[journals.lww.com]
  • Pathogenesis Etiology Often idiopathic - dysfunction of colonic smooth muscle, progressive post-receptor defect in excitation-contraction coupling. Secondary to colonic obstruction: Extraluminal compression, eg pelvic fracture.[vetstream.com]
  • There are three etiological types of megacolon: acute, chronic, and toxic megacolon.[amboss.com]
  • It can also be classified according to etiology. [4] Signs and symptoms External signs and symptoms are constipation of very long duration, abdominal bloating, abdominal tenderness and tympany, abdominal pain, palpation of hard fecal masses and, in toxic[ipfs.io]
  • It can also be classified according to etiology. [ 4 ] Signs and symptoms External signs and symptoms are constipation of very long duration, abdominal bloating, abdominal tenderness and tympany, abdominal pain, palpation of hard fecal masses and, in[dictionnaire.sensagent.leparisien.fr]

Epidemiology

  • Epidemiology Frequency United StatesNo large-scale studies have been conducted to determine prevalence/incidence of acquired megacolon. InternationalThe most common cause of megacolon worldwide is infection with Trypanosoma cruzi (Chagas disease).[thehealthscience.com]
  • Chagas megacolon. [3] Of the 34% of asymptomatic patients who demonstrated similar patterns of autoantibodies, 84% of these individuals also had levels of beta1 autoantibody that are typical for Chags cardiomyopathy, which the authors stated mirrored the epidemiologic[emedicine.medscape.com]
  • Epidemiology Sigmoid volvulus is a leading cause of acute colonic obstruction in South America, Africa, Eastern Europe and Asia but is rare in developed countries such as the USA, UK, Japan and Australia. [ 1 ] Sigmoid volvulus is the third leading cause[patient.info]
  • Epidemiology of congenital innervation defects of the distal colon.[jcol.elsevier.es]
Sex distribution
Age distribution

Pathophysiology

  • BACKGROUND: The pathophysiology of constipation is not clearly identified as yet, and the interstital cells of Cajal (ICC), known to generate the slow wave activity and to be involved in intestinal neurotransmission and the enteric nervous system (ENS[ncbi.nlm.nih.gov]
  • Links: pathophysiology clinical features investigation management prognosis[gpnotebook.co.uk]
  • Pathophysiology Failure of motor function or obstruction to passage of feces loss of colonic motor activity normal defecation prevented over prolonged period colon distends further muscle degeneration colon flaccid and filled with dry, hard fecal material[vetstream.com]
  • The pathophysiology of chronic megacolon is incompletely understood.[thehealthscience.com]
  • ., anticholinergic drugs, opioid analgesics, antipsychotics, calcium channel blockers ) Pathophysiology Etiological factors impairment/destruction of the autonomic nervous system imbalance between sympathetic and parasympathetic control of intestinal[amboss.com]

Prevention

  • Pathophysiology Failure of motor function or obstruction to passage of feces loss of colonic motor activity normal defecation prevented over prolonged period colon distends further muscle degeneration colon flaccid and filled with dry, hard fecal material[vetstream.com]
  • To prevent leakage of the rectal-stump suture, the section and suture must be 3 to 6 cm above the peritoneal reflection.[link.springer.com]
  • Children will also receive fluids to prevent dehydration and shock.[livestrong.com]
  • Prevention of colon enlargement may be achieved by consumption of food rich in fibers and specific measures against constipation. And timely treatment of inflammatory bowel disease may be another form of prevention against colon enlargement.[ic.steadyhealth.com]
  • Surgery After conservative treatment, further episodes of volvulus often occur and elective surgery is then frequently required to prevent further recurrence.[patient.info]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!