Weight loss will also occur with hypopituitarism which also presents with secondary amenorrhoea. [endobible.com]

Presentation The most common presentations are primary or secondary amenorrhoea [ 2 ]. However, abnormal bleeding patterns also include oligomenorrhoea. [patient.info]

Antenatal diagnosis Not relevant at present. Management Patients with POF have infertility and hormone deficits. At present, fertility cannot be restored if the diagnosis is made after complete follicular depletion. [ojrd.biomedcentral.com]

The clinical presentation of POI can be variable, but the most common presenting symptom is menstrual disturbance, particularly oligomenorrhoea or amenorrhoea. [racgp.org.au]

The last two markers tested, DXS1073 and DXS1108 were both present in heterozygote state in the three women. The deletion is therefore interstitial and the last 3 Mb of Xq28 are present in the three patients. [nature.com]

S. married, but after a complicated and frustrating infertility workup and treatment regimen, including fertility drugs and varying procedures without a successful pregnancy, she now age 32 divorced her husband. [fertilitysolution.com]

A review of the literature of 33 cytogenetic studies composed of 1,757 phenotypic females with primary amenorrhea revealed a 32% incidence of chromosome abnormalities. 22 Figure 1 gives a schematic outline of the laboratory workup. Fig. 1. [glowm.com]

Treatments for early menopause The main treatment for early menopause is either the combined contraceptive pill or HRT to make up for your missing hormones. [nhs.uk]

Treatment of Premature Ovarian Failure Treatment addresses the issues that premature ovarian failure caused. Treatment is to replace the hormone estrogen, restore fertility and to take care of the psychological well-being of the patient. [medthical.com]

Regardless of the etiology, there currently is no effective treatment that will be likely to result in a pregnancy (with her own eggs) for premature ovarian failure. Egg donation is a highly successful treatment (see below). [advancedfertility.com]

Currently there is no treatment for premature ovarian insufficiency. [fertility-texas.com]

[…] reach the average age of menopause (about age 51), when treatment may be reassessed. [merckmanuals.com]

Prognosis Sex steroid replacement for women with POI up to the normal age of natural menopause will not only improve symptoms but also reduce the risk of osteoporosis and cardiovascular disease. [patient.info]

However, it has some practical clinical value in that it may give a clue to etiology and prognosis. [glowm.com]

We present a case of premature ovarian failure in a 16 year-old girl and discuss the possible etiology, treatment and follow-up in these cases. [ispub.com]

These patients exhibit amenorrhoea, elevated gonadotropin levels and subnormal estrogen levels with or without typical menopausal symptoms. 1 Etiology The exact etiology of this disease entity is unknown, but it is suggested that some patients might be [fertilitysolution.com]

Regardless of the etiology, patients with primary ovarian insufficiency are estrogen deficient. [acog.org]

Etiology Because multiple factors may play a role in the development of secondary amenorrhea, it is difficult to construct a complete etiologic classification. [glowm.com]

Relevant External Links for POF1B Genetic Association Database (GAD) POF1B Human Genome Epidemiology (HuGE) Navigator POF1B Atlas of Genetics and Cytogenetics in Oncology and Haematology: POF1B No data available for Genatlas for POF1B Gene Mutation analysis [genecards.org]

Epidemiology At least 1% of women under the age of 40 are affected. [patient.info]

Little and Ward even suggest an epidemiological study of young women vaccinated with quadrivalent HPV vaccine versus those not vaccinated against HPV with long term followup of ovarian function. This is a ridiculous suggestion. [scienceblogs.com]

Epidemiology POF affects approximately: one in 10,000 women by age 20; one in 1,000 women by age 30; one in 100 women by age 40 [ 3 ]. The familial form of POF is rare, representing 4 to 31% of all cases of POF [ 4 – 6 ]. [ojrd.biomedcentral.com]

It also avoids the first-pass effect in the liver. [34] Epidemiology [ edit ] It has been estimated that POF affects 1% of the female population. [35] History [ edit ] Fuller Albright et al. in 1942 first reported a syndrome in young women characterized [en.wikipedia.org]

This distinction is descriptive and artificial, because the underlying pathophysiologic conditions responsible for primary or secondary amenorrhea may be similar. [glowm.com]

Pathophysiology POI is, in reality, a continuum of disorders. Dividing the continuum of ovarian insufficiency into 4 clinical states is the authors' preferred method to facilitate explanation. These states are not permanent. [emedicine.medscape.com]

Estrogen can be given orally or transdermally either continuously or cyclically (21 days on then 7 days off).Estrogen therapy does not prevent pregnancy and ovulation. [medthical.com]

The authors report a case of ovarian failure in a 16 year old girl, most likely due to Savage Syndrome, who started hormonal replacement for normal development of sexual characteres and for osteoporosis prevention. [ispub.com]

Doctors usually prescribe calcium and vitamin D supplements to prevent bone loss, which can happen when estrogen levels drop. [webmd.com]

To help prevent osteoporosis, women with primary ovarian insufficiency should consume an adequate amount of calcium and vitamin D (in the diet and/or as supplements). [merckmanuals.com]

 Mx of female hypogonadism: o In ovarian failure oestrogens (alleviate deficiency syndromes and prevent long-term complications), such as osteoporosis o Progesterones are added for women with an intact uterus to avoid endometrial hyperplasia and subsequent [mymedicalstudentnotes.com]