Presents comprehensive coverage of valvular heart disease to provide you with a complete reference and one-stop shop for this specialty in cardiac medicine. [books.google.com]

We present a case of a 65-year-old woman, with a known history of breast carcinoma, status after wide excision (T1N0Mx) in 2010, who presented with a 0.6 × 0.5-cm, nontender pink nodule in the right inferior axilla of 1 week duration on the same side [ncbi.nlm.nih.gov]

We present a case of a 65-year-old woman, with a known history of breast carcinoma, status after wide excision (T1N0Mx) in 2010, who presented with a 0.6×0.5-cm, nontender pink nodule in the right inferior axilla of 1 week duration on the same side as [mdanderson.influuent.utsystem.edu]

[…] searches within MalaCards or GeneCards Suite gene sharing: MalaCards organs/tissues related to Acquired Pseudoxanthoma Elasticum: 42 Skin, Liver Articles related to Acquired Pseudoxanthoma Elasticum: # Title Authors Year 1 Acquired pseudoxanthoma elasticum presenting [malacards.org]

• Beta Thalassaemia Major

  Imaging manifestations of acquired elastopathy resembling pseudoxanthoma elasticum in patients with beta thalassaemia major and sickle cell disease. Journal of Medical Imaging and Radiation Oncology, Vol. 60, Issue. 1, p. 74. [cambridge.org]

• Papule

  Although skin laxity is present in cutis laxa and pseudoxanthoma elasticum, yellowish papules in a cobblestone pattern are not characteristic of cutis laxa. [aafp.org]

  This under-recognized presentation has previously ... more We report 2 women, aged 83 and 63 years, who presented with multiple asymptomatic, slowly progressive, coalescing, skin-colored papules affecting the sides of the neck and lower abdomen. [scinapse.io]

  Figure 3: Hyperkeratotic nonfollicular papules and atrophic scars arranged in a serpiginous seen on the sides of the neck Click here to view Histopathology of the biopsy specimen from a hyperkeratotic papule revealed hyperplastic epidermis. [idoj.in]

  Figure 1: Multiple brownish-black papules on the sides of the neck, with soft, lax, and wrinkled overlying skin Click here to view Figure 2: Multiple brownish-black papules with soft, lax, and wrinkled skin in the periumbilical area Click here to view [e-ijd.org]

  Skin-colored and yellowish papules and skin laxity of the neck. Figure 2. Skin-colored and yellowsh papules associated with skin laxity of the axilla. Figure 3. Yellowish papules on the mucosal aspect of the lower lip. [dermatologyadvisor.com]

• Cutaneous Manifestation

  An unusual cutaneous manifestation of pseudoxanthoma elasticum mimicking reticulate pigmentary disorders. Br J Dermatol 1996;134:1157-9. [ PUBMED ] 9. Sapadin AN, Lebwohl MG, Teich SA, Phelps RG, DiCostanzo D, Cohen SR. [e-ijd.org]

  Two are inherited as an autosomal dominant characteristic, three are autosomal recessive History PXE is slightly more prevalent in women, with no racial predilection The first manifestation is usually cutaneous, which is normally noticed around the teenage [pcds.org.uk]

  An unusual cutaneous manifestation of pseudoxanthoma elasticum mimicking reticulate pigmentary disorders. Br J Dermatol. 1996 Jun. 134(6):1157-9. [Medline]. McDonald HR, Schatz H, Aaberg TM. [emedicine.staging.medscape.com]

  manifestations have been identified in some patients with congenital anemias, such as beta-thalassemia, sickle cell disease, and spherocytosis. 5, 9 All of these situations associated with pseudoxanthoma elasticum-like syndrome have in common a disruption [ispub.com]

  An unusual cutaneous manifestation of pseudoxanthoma elasticum mimicking reticulate pigmentary disorders. Br J Dermatol 1996 ; 134 : 1157 –9. ↵ Uenishi T, Uchiyama M, Sugiura H, et al. Pseudoxanthoma elasticum with generalized cutaneous laxity. [adc.bmj.com]

• Skin Ulcer

  Kirsner, “Leg Ulcers in Sickle Cell Disease,” Advances in Skin & Wound Care, Vol. 17, No. 8, pp. 410-416. doi:10.1097/00129334-200410000-00010 [ 7 ] F. Wolfort and T. [scirp.org]

As a result, haemoglobin electrophoresis should be considered in the standard workup of every patient presenting with clinical and/or histological features resembling PXE (Figure 21). [cmgg.be]

Herein a clinical case of a localized acquired cutaneous pseudoxanthoma elasticum after treatment with Striadril complex-containing anti-wrinkle cream is described. [kosmetischemedizin-online.de]

diagnosis and treatment. [globenewswire.com]

Prognosis Life expectancy is usually normal, although sudden, unexpected death can occur involving accelerated atherosclerosis with acute myocardial ischaemia, hypertension, mitral valve prolapse, restrictive cardiomyopathy, GI haemorrhage and cerebral [patient.info]

Oxidative stress has also been reported to play an important role in the mechanism of the calcifications and hence in the pathogenesis of PXE. [10] The prognosis in PXE largely depends on the extent of extracutaneous organ involvement, and life expectancy [e-ijd.org]

TREATMENT AND PROGNOSIS CHARACTERIZATION PROGNOSIS PREGNANCY Pseudoxanthoma elasticum and pregnancy. Xiromeritis P, Valembois B. [thedoctorsdoctor.com]

[…] and Martinez-Hernandez proposed the term “localized acquired cutaneous pseudoxanthoma elasticum,” as they believed that the process was “acquired” and was lacking “systemic involvement.” [18] Differentiating the above conditions is important as the prognosis [idoj.in]

This leads to arterial stenosis and heart failure within the first months of life and is associated with a poor prognosis (Figure 20). Although survival to adulthood has been reported, GACI has been often lethal in the first six months of life. [cmgg.be]

These 2 cases represent pseudoxanthoma elasticum-like papillary dermal elastolysis, a recently described entity, the etiology of which remains unclear. [scinapse.io]

Etiology This is an autosomal recessive disorder of connective tissue caused by mutations in the ABCC6 gene. Rarely, it is caused by mutations in GGCX or by a combination of deleterious ABCC6 and GGCX mutations.. [dermatologyadvisor.com]

T hese 2 cases represent pseudoxanthoma elasticum-like papillary dermal elastolysis, a recently described entity, the etiology of which remains unclear. [thedoctorsdoctor.com]

Germany Epidemiology 7.5.2. France Epidemiology 7.5.3. Italy Epidemiology 7.5.4. Spain Epidemiology 7.5.5. United Kingdom Epidemiology 7.5.6. Japan Epidemiology 8. Treatment Algorithm, Current Treatment, and Medical Practices 8.1. [globenewswire.com]

This report defines the prevalence of genital colonization in a large population of women, characterizes the women with S. aureus, and describes epidemiologic features of genital carriage. ‎ Página 50 - Lautenschlager S, Eichmann A. [books.google.es]

Epidemiology Pseudoxanthoma elasticum (PXE) is a recessive disorder with a prevalence of between 1 in 25,000 and 1 in 100,000. [ 1 ] It is caused by mutations in the ABCC6 gene on chromosome 16p13.1. [patient.info]

Pathophysiology 5.4. Risk Factors 5.5. Diagnosis 6. Patient Journey 7. Pseudoxanthoma Elasticum Epidemiology and Patient Population 7.1. Epidemiology Key Findings 7.2. Assumptions and Rationale: 7MM 7.3. Epidemiology Scenario: 7MM 7.4. [globenewswire.com]

Despite growing insights in the clinical diversity and pathophysiological mechanisms of this disease spectrum, a significant number of questions remain. [frontiersin.org]

Causes 2.5.Pathophysiology 2.6. Pseudoxanthoma Elasticum Diagnosis 2.6.1. Diagnostic Guidelines 3. Pseudoxanthoma Elasticum Current Treatment Patterns 3.1. Pseudoxanthoma Elasticum Treatment Guidelines 4. [delveinsight.com]

These pathophysiological mechanisms are however not mutually exclusive and display significant crosstalk. Figure 1: Schematic representation of the pathophysiological mechanisms leading to ectopic mineralization. [cmgg.be]

Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet. 2005 Dec;42(12):881-92. Epub 2005 May 13. Review. Dabisch-Ruthe M, Kuzaj P, Götting C, Knabbe C, Hendig D. [ghr.nlm.nih.gov]

The most important aspect of treatment is to ensure that complications from blood vessel involvement are prevented or dealt with speedily by the appropriate specialist. [dermnetnz.org]

Alternatively, a lack of functioning MRP6 may impair the transport of a substance that would normally prevent mineralization, leading to the abnormal accumulation of calcium and other minerals characteristic of PXE. [ghr.nlm.nih.gov]

Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. ‎ Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. ‎ [books.google.es]

There is no means of prevention and there is no antenatal test for the condition. [patient.info]