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Acquired Spherocytosis


  • The Peripheral Blood Film, Second Edition presents the various concepts of the origin, development, and functions of blood cells.[books.google.de]
  • The purpose of the present article was to review the neonatal presentation of HS and to provide practical and up-to-date means of diagnosing and treating HS in neonates.[pediatrics.aappublications.org]
  • Most often, it presents in middle-aged and older individuals. Presentation Symptoms Symptoms are due to both anaemia and the underlying disorder. Patients with minimal or long-standing haemolytic anaemia can be asymptomatic.[patient.info]
  • This patient’s case demonstrates the clinical utility of high-density array karyotyping to define atypical clinical presentations and highlights the variable natural history of myelodysplastic syndromes.[bloodjournal.org]
  • If agglutination occurs, IgG antibodies (autoantibodies or alloantibodies) against RBCs are present. This test is also used to determine the specificity of an alloantibody.[msdmanuals.com]
Hemophilia A
  • GIST) 消化管間質腫瘍 gene遺伝子 gene rearrangement遺伝子再編成 gene therapy遺伝子治療 granulocyte colony stimulating factor (G-CSF)顆粒球増殖因子 h hematopoietic organ 造血器 hematopoietic stem cell造血幹細胞 hemolytic uremic syndrome (HUS)溶血性尿毒性症候群 hemophagocytic syndrome (HPS)血球貪食症候群 hemophilia[tokyo-med.ac.jp]
  • This book is a valuable resource for hematologists and pathologists.[books.google.de]
  • Tissue pathways for urological pathology The target primary users of the tissue pathway are trainee and consultant cellular pathologists. These recommendations will also be of value to trainee/qualified biomedical scientists involved in...[evidence.nhs.uk]
  • […] leukemia (ALL)急性リンパ性白血病 acute monoblastic leukemia (AMoL)急性単球性白血病 acute myeloblastic leukemia (AML)急性骨髄性白血病 acute promyelocytic leukemia (APL)急性前骨髄球性白血病 adult T-cell leukemia (ATL)成人T細胞性白血病 aggregation凝集 agranulocytosis無顆粒球症 allogeneic transplantation同種移植 amyloidosis[tokyo-med.ac.jp]
Loss of Attention
  • For example, hemorrhagic blood loss requires attention to the integrity of anatomic and coagulation systems and is generally responsive to red cell transfusion.[cancertherapyadvisor.com]
  • In many cases the location of hemorrhage may be obvious--or easily deduced--from the patient's history and physical exam: trauma, surgical sites, extensive hematoma, melana, hematemesis, menorrhagia, epistaxis, third-space hemorrhage (Cullen's sign, Turner's[cancertherapyadvisor.com]
  • Perhaps the intense focus on reducing the elevated bilirubin level into a safe range sometimes results in neglecting evaluation of how the bilirubin became so high in the first place. 14 Approximately 65% of neonates with HS have a parent with HS. 1 ,[pediatrics.aappublications.org]


  • Diagnosis Diagnostic tests For all anemias: Because many therapies--especially erythrocyte transfusions--can interfere with the diagnostic workup, it is generally recommended that, if possible, relevant studies of whole blood, plasma, and serum are obtained[cancertherapyadvisor.com]
Bone Marrow with Hyperplasia
  • marrow erythroid hyperplasia -Jaundice (due to Bilirubin) -Red Plasma Inherited Hemolysis Disorders -RBC membrane disorders -hereditary spherocytosis -hereditary elliptocytosis -RBC enzyme disorders -G6PD deficiency -PK deficiency -RBC hemoglobin disorders[quizlet.com]


  • Treatment The symptoms of HS are treatable, but the inherited red blood cell defect is not curable. The treatment for young children and those with mild HS may include oral folic acid which is needed to make RBC’s.[ihtc.org]
  • Treatment of acute hyperkalaemia in adults [PDF] This guideline has been developed to improve the treatment of acute hyperkalaemia and reduce the risk of complications associated with hyperkalaemia and its treatment. This guideline is a...[evidence.nhs.uk]
  • Treatment can also include dietary supplements. It is best to consult with doctor about the proper treatment plan for this disorder.[primehealthchannel.com]
  • TABLE 2 Laboratory Evaluation for HS in a Jaundiced Neonate Treatment Phototherapy should reduce the bilirubin level of jaundiced neonates with HS, and it is the mainstay of treatment in the first days after birth. 33 – 35 When a bilirubin level is found[pediatrics.aappublications.org]


  • When detected and cured early, patients of the condition show a good prognosis and the recovery time is much lesser in duration. References :[primehealthchannel.com]
  • The prognosis of an anemia is largely dictated by the prognosis of the corresponding underlying disorder. The patient should be continually monitored and supportive care provided while disease-specific therapy is administered.[cancertherapyadvisor.com]
  • What we see as the essence: "NRBC are often an only transient observation, but they indicate a poor prognosis, whether transient or persistent."[sysmex.de]


  • The patient's medical records provide an invaluable resource for differentiating congenital from acquired etiologies.[cancertherapyadvisor.com]
  • Once hemolysis has been identified, the etiology is sought.[msdmanuals.com]
  • The etiologies of hemolysis often are categorized as acquired or hereditary. Common acquired causes of hemolytic anemia are autoimmunity, microangiopathy, and infection.[aafp.org]
  • FIGURE 5 Evaluating a neonate with problematic jaundice in whom the etiology is unclear. Not all neonates who receive phototherapy for 2 days have hemolytic jaundice.[pediatrics.aappublications.org]


  • Methods Statistics Trigonometry Medical & Nursing Anatomy Anesthesiology Audiology Bacteriology Biochemistry Bioethics Biomedical Science Cardiology Cardiovascular Childbirth Chiropractic Dentistry Dermatology Diagnostic Imaging Drugs Endocrinology Epidemiology[brainscape.com]
  • Epidemiology Risk factors are variable and depend on the underlying cause.[patient.info]
  • Epidemiology The wide variability in the reported prevalence of anemia results, in part, from the lack of standard universal definitions.[cancertherapyadvisor.com]
Sex distribution
Age distribution


  • Some anemias may result from more than one pathophysiology (e.g., gastrointestinal losses and nutritional reticulocytopenia in alcoholics). Knowledge of the relevant pathophysiology can guide diagnostic and treatment strategies.[cancertherapyadvisor.com]
  • Paroxysmal Nocturnal Hemoglobinuria (PNH) Discuss the molecular and pathophysiologic defects in paroxysmal nocturnal hemoglobinuria (PNH) and explain the test used to diagnose this disorder. List complications of PNH.[hematology.org]
  • […] hemolytic transfusion reactions ABO hemolytic diseases of newborn/Rh hemolytic disease of newborn Hereditary spherocytosis Intravenous water infusion or drowning (fresh water) hypophosphatemia Bartonellosis Snake bite hyposplenism Rh-null phenotype Pathophysiology[en.wikipedia.org]
  • Disorders of hemoglobin synthesis Hb C disease Hb E disease Hb S-C disease Sickle cell disease Thalassemias Disorders of RBC metabolism Embden-Meyerhof pathway defects (eg, pyruvate kinase deficiency) Hexose monophosphate shunt defects (eg, G6PD deficiency) Pathophysiology[msdmanuals.com]
  • Pathophysiology There are two mechanisms of hemolysis. Intravascular hemolysis is the destruction of red blood cells in the circulation with the release of cell contents into the plasma.[aafp.org]


  • Spherocytosis Prevention As this is an inherited disease, it is impossible to prevent its occurrence. However, regular screening and early treatment of high-risk individuals can help avoid the risk of complications of the condition.[primehealthchannel.com]
  • A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA. Altamura S, D'Alessio F, Selle B, Muckenthaler MU. Biochem J. 2010 Nov 1;431(3):363-71. doi: 10.1042/BJ20100668. Two to tango: regulation of Mammalian iron metabolism.[klinikum.uni-heidelberg.de]
  • A splenectomy does not cure this disease, but it can cure the anemia and prevent the development of gallstones. Since the spleen is a filter of bacteria for the body, its removal can result in an increased risk of certain infections.[ihtc.org]
  • We predict that early suspicion, prompt diagnosis and treatment, and anticipatory guidance will prevent adverse outcomes in neonates with HS.[pediatrics.aappublications.org]
  • The mean corpuscular hemoglobin concentration frequently is elevated. 2 , 21 Splenectomy effectively arrests the extravascular hemolysis and prevents its long-term complications, such as cholelithiasis and aplastic crises.[aafp.org]

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