The clinical investigations vary somewhat between cases as the four patients presented in markedly different ways. [onlinelibrary.wiley.com]

[…] adrenocorticotropic hormone deficiency potentially induced by nivolumab following pseudo-progression in clear cell renal cell carcinoma: A case report. ( 30680212 ) Furubayashi N...Nakamura M 2019 3 Idiopathic and isolated adrenocorticotropic hormone deficiency presenting [malacards.org]

The numbered bands specify the location of the thousands of genes that are present on each chromosome. [rarediseases.org]

• Nausea

  Symptoms are the same as for Addison disease and include fatigue, weakness, weight loss, nausea, vomiting, and diarrhea, but there is usually less hypovolemia. [msdmanuals.com]

  Symptoms include weight loss, lack of appetite (anorexia), muscle weakness, nausea and vomiting, and low blood pressure (hypotension). [rarediseases.org]

Such treatment does not negate the results of the test, and blood sampling should continue until the completion of the study. The glucagon stimulation test is one last convenient test that may be used. [medscape.com]

Up to now, the patient has been in a stable disease state for 15 months after nivolumab treatment and obtained survival benefit from the treatment. [dovepress.com]

In the meantime, we cannot recommend systematic steroid treatment, in particular, hydrocortisone treatment, in patients with D21OH-NC. [em-consulte.com]

Treatment All patients with CAH, regardless of form, are treated with glucocorticoid replacment therapy. [vivo.colostate.edu]

TREATMENT AND COURSE: Under therapy with hydrocortisone 20 mg and fludrocortisone 0.05 mg orally the clinical symptoms of the patient improved impressively. The patient became efficient and dynamic. [ncbi.nlm.nih.gov]

Discussion SCLC is an aggressive malignancy with rapid progression and poor prognosis. [dovepress.com]

Another possible etiology is autoimmune disease. [dovepress.com]

VIVO Pathophysiology Congenital adrenal hyperplasias (CAH) are a group of heritable disorders associated with an inability or deficiency in the ability to produce cortisol. [vivo.colostate.edu]

This not only alleviates glucocorticoid (i.e. cortisol) deficiency, but more importantly, provides negative feedback to suppress ACTH secretion and prevent continued adrenal stimulation. [vivo.colostate.edu]

However, in this publication, there was no mention of previous steroid treatment, which prevents one from drawing any clear conclusion. [em-consulte.com]

Appropriate and prompt treatment should be taken to prevent life-threatening adrenocortical crisis. Ethics approval We confirm that written informed consent was provided by the patient to have the case details and any accompanying images published. [dovepress.com]