Actinic prurigo falls within the category of idiopathic photosensitive dermatoses, but it has several distinguishing characteristics. Its onset is usually within the first decade of life and it may improve by puberty. [mdedge.com]

In geographical areas where seasons are well defined, flares usually occur during spring and summer and decrease in the fall [ 9, 15 ]. [obgynkey.com]

If a fall from baseline values of more than 40% on repeat testing is detected, the treatment should be discontinued. Thromboembolic complications have been reported with thalidomide, particularly in patients with cancer. [dermatologyadvisor.com]

Skin lesions associated with actinic prurigo are infiltrated with T lymphocytes, mostly CD4+, and some of the T-cells express activation markers. [4] Actinic prurigo falls in the category of autoimmune diseases because lymphocytes from patients have been [emedicine.medscape.com]

He was started on methotrexate 15 mg orally once weekly, however, due to gastrointestinal symptoms, not only switched to subcutaneous administration but also discontinued due to extreme fatigue. [journals.sagepub.com]

The lack of vesicles, burning pain, crusting, scarring, or an elevated red blood cell protoporphyrin test ruled out other differential diagnoses, including hydroa vacciniforme and erythropoietic protoporphyria. Dr. [mdedge.com]

In severe cases, excoriations, cheilitis, conjunctival disease, and scarring may develop. Actinic prurigo is typically described in prepubescent females but can occur at any age or gender. [ncbi.nlm.nih.gov]

Histologic Features: Acute lesions (indistinguishable from polymorphous light eruption): Spongiosis Superficial dermal perivascular lymphocytic infiltrate Dermal edema Chronic lesions: Hyperkeratosis Acanthosis Signs of photoadaptation External Links: [dermpedia.org]

Histology of APC shows hyperkeratosis, scale crusts covering ulcerated areas, mild acanthosis, spongiosis, and mild vacuolar alteration of the basal layer. [obgynkey.com]

Skin biopsies will show hyperkeratosis, spongiosis, and acanthosis in the epidermis with lymphocytic perivascular infiltration in the dermis. [ncbi.nlm.nih.gov]

Other historical terms for the disease include solar eczema, prurigo solar, hereditary polymorphic light eruption, and hydroa aestivale. 1 AP occurs throughout much of the world. [accessmedicine.mhmedical.com]

Photoaggravated atopic dermatitis – assess for personal and family history of atopy, predominance in flexures; should respond to usual eczema treatment. Lymphomatoid papulosis – skin biopsies. [visualdx.com]

Actinic prurigo may look very like atopic dermatitis ( eczema ) but is more severe on sun-exposed sites. Areas affected include: Sun-exposed areas of the face such as the cheeks, nose, forehead, chin and earlobes. [dermnetnz.org]

The symptoms of actinic prurigo include: Extremely itchy (pruritic) skin rash; Red and inflamed bumps (papules); Thickened patches (plaques); and/or Lumps (nodules) The symptoms of AP are often described as similar to those seen in atopic dermatitis (eczema [clinuvel.com]

Since the lesions are intensely pruritic, excoriations, skin thickening, scarring, and hyper- or hypopigmentation may occur. Actinic cheilitis has been described as a hallmark finding in patients with actinic prurigo. [ncbi.nlm.nih.gov]

Congenital varicella syndrome is characterized by microcephaly, limb hypoplasia, cutaneous defects, hypopigmented skin, and autonomic neuropathy. Herpes zoster: The skin lesions that occur in herpes zoster are similar to those in varicella. [clinuvel.com]

Treatment with thalidomide has a major limiting side effect profile which includes peripheral neuropathy and teratogenicity. Treatment with thalidomide is contraindicated during pregnancy or in individuals trying to become pregnant. [ncbi.nlm.nih.gov]

Adverse effects include drowsiness, headache and weight gain. Nerve conduction studies should be performed regularly to assess for peripheral neuropathy, another side-effect of thalidomine treatment. [clinuvel.com]

He responded well, but azathioprine was eventually stopped due to gastrointestinal side-effects and headache. Patient 6 was treated with azathioprine for a few months, but this was stopped due to side-effects. [ijdvl.com]

AP cheilitis should not be confused with actinic cheilitis because they are separate entities. [ijpmonline.org]

These reactions are usually caused by a confused immune system which reacts to compounds in sun-exposed skin. This is the commonest cause of sunlight reactions. actinic prurigo vs pmle [ekometal.com.tr]

Histologic Features: Acute lesions (indistinguishable from polymorphous light eruption): Spongiosis Superficial dermal perivascular lymphocytic infiltrate Dermal edema Chronic lesions: Hyperkeratosis Acanthosis Signs of photoadaptation External Links: [dermpedia.org]

At the superficial portion of the submucosa, eosinophils and melanophages can be found, and deeper in the lamina propria, there are dilated capillary vessels, interstitial edema, and a band-like or nodular lymphocytic infiltrate. [obgynkey.com]

The basal cells are vacuolised with lymphocytic infiltration in the sub-mucosal follicles. Eosinophils are conjunctival pigmentation are common findings. [clinuvel.com]

Common histopathological features of AP are hyperkeratosis, parakeratosis, acanthosis, thickening of the basement membrane, perivascular inflammatory, lymphoid follicles, or nodular lymphocytic infiltrate, as well as eosinophils, mast cells, and angiogenesis [ijpmonline.org]

It is necessary to differentiate AP from polymorphic light eruption, which is clinically similar, but microscopically does not show lymphocytic infiltrate with lymphoid follicles[ 12 ]. [wjgnet.com]