We report a 50-year-old male with a history of diabetes who presented with pancytopenia, neutropenia, and worsening hypoxemia, ultimately requiring intubation and transfer to the MICU in March 2013. [jscimedcentral.com]

Contrast-enhanced computed tomography scan of orbits showed diffuse bone lysis with periosteal reaction involving skull base, skull vault and bilateral bony orbits with associated soft tissue masses extending intracranially, consistent with marrow infiltrative [ijpmonline.org]

Examination revealed an irritable infant with anemia and bilateral proptosis. The tip of spleen was palpable. There were no petechiae, lymphadenopathy, gum hyperplasia, urticaria, flushing or circulatory disturbance. [ijpmonline.org]

Today in report, Kat Chau dropped some awesome R3 knowledge when she presented the case of a 64 yo veteran who initially presented with chronic cough and medication refill, but on further history and lab review was found to have a new leukocytosis to [ucsfmed.wordpress.com]

Today in report, Kat Chau dropped some awesome R3 knowledge when she presented the case of a 64 yo veteran who initially presented with chronic cough and medication refill, but on further history and lab review was found to have a new leukocytosis to [ucsfmed.wordpress.com]

Earlier observations have linked bone marrow basophilia either to a deletion of the short arm of chromosome 12 (p11-13), to translocations involving the long arm of chomosome 6 at 6q23 or to the translocation t(6,9); (p23;q34). [ncbi.nlm.nih.gov]

Earlier observations have linked bone marrow basophilia either to a deletion of the short arm of chromosome 12 (p11–13), to translocations involving the long arm of chomosome 6 at 6q23 or to the translocation t(6,9); (p23;q34). [ingentaconnect.com]

It corresponds to shortened chromosome 22 resulting from reciprocal translocation between long arm of chromosome 9 and short arm of chromosome 22, which is designated as t(9;22)(q34;q11). [neoplasm.imedpub.com]

[…] organomegaly Clinical features Wide age range: 1 day to 82 years ( Leuk Lymphoma 1999;32:269 ) Typically presents with bone marrow failure, variable circulating blasts Skin conditions due to high histamine levels are pruritus, edema, urticarial rashes, focal hyperpigmentation [pathologyoutlines.com]

This 7-month-old male infant presented with irritability and bilateral proptosis of 3 weeks duration. Examination revealed an irritable infant with anemia and bilateral proptosis. The tip of spleen was palpable. [ijpmonline.org]

This interpretation is supported by the coagulation studies, which suggested release of heparin from the blast granules. [ncbi.nlm.nih.gov]

The blasts often had basophil-like dark coarse granules, and basophils had characteristic confluent vacuoles merged with the cell membrane suggestive of degranulation (panel B). Blasts were toluidine blue metachromatic but myeloperoxidase . [bloodjournal.org]

Numerous karyotypic abnormalities have been reported in ABL, like normal karyotype, translocation t(X; 6) (p11; q23), monosomy 7 and trisomy 8. [2], [3], [4] Though no cytogenetic abnormality is characteristic of ABL, cytogenetic and molecular studies [ijpmonline.org]

abnormalities,-5—7,3q26 aberrations, t(6;9), 11q23 aberrations Review Questions The correct answers can be found below the references. 1. [lecturio.com]