Presentation
This quick-reference handbook presents the principles and practices of respiratory care in a clear, concise, easy-to-follow bulleted format enhanced by abundant illustrations and tables. [books.google.com]
If giant cells are rare, resembles DIP Foci of centrilobular fibrosis and interstitial inflammatory infiltrate BOOP -like changes may be present Gerald J Berry MD Robert V Rouse MD Department of Pathology Stanford University School of Medicine Stanford [surgpathcriteria.stanford.edu]
In developing its educational products ATSDR has made a diligent effort to ensure the accuracy and the currency of the presented information. [atsdr.cdc.gov]
The following criteria need to be present for a definitive diagnosis: history of beryllium exposure positive blood or bronchoalveolar lavage (BAL) beryllium lymphocyte proliferation test (BeLPT) non-caseating granulomas on lung biopsy CT Reported CT findings [radiopaedia.org]
Entire Body System
- Fever
Over time, the inflammation response continues, and eventually symptoms may appear, including: Difficulty breathing/ shortness of breath Weakness Fatigue Loss of appetite Weight loss Joint pain Cough Fever Cleveland Clinic News & More Cleveland Clinic [my.clevelandclinic.org]
Symptoms include dyspnea, cough, fever. CXR: Basilar reticular or fine nodular changes. [lumen.luc.edu]
Conjunctivitis Skin irritation Skin ulcers Nausea Pneumonitis Vomiting Right-sided heart failure Pulmonary fibronodular disease Weakness Eye irritation Weight loss Fever CBD patients may develop a kind of lung scarring known as granuloma. [chronicberylliumdisease.com]
The chronic form of berylliosis develops along with symptoms of dyspnea or exertion, cough, fatigue, chest pain, weight loss, night sweats, fever and anorexia. [occupational-injury.com]
The inhalation of moderately concentrated vapours and fumes may be the source of an episode of ‘metalworkers’ fever’. [euroliver.org]
Respiratoric
- Cough
The acute disease involves both skin and lungs, causing a burning rash, eye irritation, nasal discharge, a cough, and chest tightness. [britannica.com]
[…] asbestos fibre asbestosis aspergilloma Aspergillus associated berylliosis beryllium biopsy bone lesions bronchi bronchial carcinoma calcification cavitation changes chest radiograph chronic clinical features coidosis collagen condition corticosteroids cough [books.google.com]
Symptoms include dry cough, fatigue, weight loss, chest pain and dyspnea. Beryllium compounds were found in fluorescent lighting before 1949. [wikilectures.eu]
Idiopathic pulmonary fibrosis : Symptoms such as dyspnea and persistent dry cough may resemble those of berylliosis. [lecturio.com]
These symptoms include: Coughing, possibly bringing up blood-tinged sputum Chest pain Shortness of breath Weight loss Copyright © Nucleus Medical Media, Inc. [cancercarewny.com]
- Dyspnea
Symptoms and Signs Early: cough, fatigue and dyspnea on exertion, chest exam may be unremarkable or reveal inspiratory crackles at lung bases. Late: dyspnea at rest, weight loss; clubbing, cyanosis, and right ventricular failure. [lumen.luc.edu]
職業歴と検査所見より慢性ベリリウム症と診断した. 24-year-old man was admitted to our hospital because of exertional dyspnea and abnormal shadows on chest X-ray film. He worked in a factory, where he was exposed to 1.8% beryllium-copper alloys. [ci.nii.ac.jp]
Symptoms include dry cough, fatigue, weight loss, chest pain and dyspnea. Beryllium compounds were found in fluorescent lighting before 1949. [wikilectures.eu]
Idiopathic pulmonary fibrosis : Symptoms such as dyspnea and persistent dry cough may resemble those of berylliosis. [lecturio.com]
Cardiovascular
- Chest Pain
These symptoms include: Coughing, possibly bringing up blood-tinged sputum Chest pain Shortness of breath Weight loss Copyright © Nucleus Medical Media, Inc. [cancercarewny.com]
Berylliosis symptoms which may develop include chest pain, a cough, unexplained weight loss, fatigue, and joint pain. People with chronic beryllium disease may also develop a skin rash, and may have swollen lymph nodes, liver, or spleen. [wisegeek.com]
The chronic form of berylliosis develops along with symptoms of dyspnea or exertion, cough, fatigue, chest pain, weight loss, night sweats, fever and anorexia. [occupational-injury.com]
These symptoms include: Coughing, possibly bringing up blood-tinged sputum Chest pain Shortness of breath Weight loss Symptoms of chronic berylliosis develop slowly. Sometimes, symptoms may not appear until many years after exposure to beryllium. [medical-clinic.org]
Symptoms include dry cough, fatigue, weight loss, chest pain and dyspnea. Beryllium compounds were found in fluorescent lighting before 1949. [wikilectures.eu]
Skin
- Skin Ulcer
Conjunctivitis Skin irritation Skin ulcers Nausea Pneumonitis Vomiting Right-sided heart failure Pulmonary fibronodular disease Weakness Eye irritation Weight loss Fever CBD patients may develop a kind of lung scarring known as granuloma. [chronicberylliumdisease.com]
Dermal Effects ❑ Skin contact with beryllium can cause ulceration and subcutaneous granulomas. Skin contact with soluble beryllium compounds can induce beryllium sensitization and cause contact dermatitis. [nap.edu]
Workup
Workup of Berylliosis The workup consists of a thorough patient history with details and duration of Be exposure, blood BePLT, bronchoscopy with bronchoalveolar lavage fluid, beryllium lymphocyte proliferation test (BePLT), pulmonary CT scan and biopsy [lecturio.com]
To make the diagnosis of CBD, the following criteria need to be satisfied: (1) evidence of sensitization to beryllium by positive findings on blood or bronchoalveolar lavage (BAL) beryllium lymphocyte proliferation test (BeLPT) (see Workup) and (2) the [emedicine.medscape.com]
X-Ray
- Pulmonary Infiltrate
Chronic Eosinophilic Pneumonia Cough, dyspnea, wheezing, fever, malaise, blood eosinophilia, and dense focal alveolar infiltrates. Cause unknown; course in subacute or chronic. CXR: "photographic negative of pulmonary edema." [lumen.luc.edu]
- Bilateral Hilar Adenopathy
CXR: - Stage 0 Clear - Stage I Bilateral hilar adenopathy - Stage II Hilar adenopathy and parenchymal infiltrates - Stage III Parenchymal infiltrates only - State IV Extensive fibrosis and distortion of lung architecture Gallium-67 Imaging: increased [lumen.luc.edu]
Treatment
Many businesses sell unreliable tests and expensive or even dangerous treatments. Hair analysis or chelation challenge tests (“provoked urine ” tests). They’re inaccurate. They can’t tell you if you’re sick or need treatment. [webmd.com]
Coverage begins with anatomy and physiology, assessment, diagnostic test results, and specific treatments. [books.google.com]
Treatment of Lyme Disease During the Different Stages of the Disease (refs. 11, 12) Clinical Stage Time Primary Treatment Alternative Treatment Early localized 3-30 days doxycycline erythromycin, amoxcillin clarithromycin cefuroxime axetil azithromycin [kleszcze.edu.pl]
Chelation therapy is currently under investigation as a treatment for the disease. Prognosis Most patients with acute berylliosis recover fully 7-10 days after treatment begins, and the disease usually causes no after effects. [encyclopedia.com]
Treatment Options and Outlook The first line of treatment is removal from the source of beryllium, which for most people means leaving the jobs that require exposure to beryllium. [beltina.org]
Prognosis
[…] lung fields lupus pernio lymph nodes lymphocytes macrophages mesothelioma mottling nerve nodular nodules occasionally occur onset opacities pathogenesis Pathology patients peripheral plaques pleural effusion pneumoconiosis polyarteritis nodosa present prognosis [books.google.com]
Treatment and prognosis While there is no cure, commonly adopted management options involve cessation of beryllium exposure and use of systemic corticosteroids 4. [radiopaedia.org]
Difficulty breathing and cough, are the main symptoms The prognosis depends on the extent of the disease. [dovemed.com]
With each acute exacerbation, though, the prognosis worsens. This occupational disease can affect workers in beryllium alloy, ceramics, foundry, grinder, cathode ray tube, gas mantle, missile, and nuclear reactor industries. [medical-clinic.org]
Prognosis Most patients with acute berylliosis recover fully 7-10 days after treatment begins, and the disease usually causes no after effects. [encyclopedia.com]
Etiology
Bronchiolitis obliterans of unknown etiology Bronchiolitis Obliterans and Organizing Pneumonia Also known as BOOP. Steroids effective. [lumen.luc.edu]
The etiology is unknown. 43. E N D CSBRP-Dec-2012 [slideshare.net]
(Etiology) Berylliosis is a form of metal poisoning caused by the airborne entry of beryllium and its compounds in the form of dust and fumes, into the lungs or via the skin Acute Berylliosis develops when beryllium dust and metal fumes are inhaled, in [dovemed.com]
As with chronic lung disease of other etiologies, one should be vigilant for bacterial respiratory infections and should treat infections promptly with antibiotics when indicated. [nap.edu]
"Is chronic beryllium disease sarcoidosis of known etiology?". Sarcoidosis, Vasculitis and Diffuse Lung Diseases. 20 (2): 104–9. [en.wikipedia.org]
Epidemiology
Hygiene and Epidemiology : Selected Chapters. First edition. 2011. ISBN 978-80-246-0793-1. KUMAR, Vinay. Pathological basis of disease. Eigth edition. 2010. ISBN 978-80-246-0793-1. LANDRIGAN, Philip J. [wikilectures.eu]
Epidemiology Frequency United States A small percentage of exposed persons (1-10%) develop beryllium hypersensitivity and a portion of those go on to develop chronic disease. [emedicine.medscape.com]
Epidemiology of Berylliosis Image : “Big crystalline fragment of Beryllium.” by Alchemist-hp = Alchemist-hp (pse-mendelejew.de) – Own work. [lecturio.com]
"Epidemiology of beryllium sensitization and disease in nuclear workers". The American Review of Respiratory Disease. 148 (4 Pt 1): 985–991. doi : 10.1164/ajrccm/148.4_Pt_1.985. ISSN 0003-0805. [en.wikipedia.org]
Several epidemiologic studies have attempted to clarify the cancer-causing effects in humans, but the published studies have drawn conflicting conclusions. [nap.edu]
Pathophysiology
Pathophysiology and Presentation of Berylliosis Beryllium is a rare earth metal, which can form alloys with several other metals. [lecturio.com]
Pathophysiology The key to the pathogenesis of chronic beryllium disease (CBD) is a delayed-type hypersensitivity reaction in which beryllium most likely functions as a hapten and acts as a class II restricted antigen, stimulating local proliferation [emedicine.medscape.com]
Prevention
The Centers for Disease Control and Prevention is authorized by IACET to offer .15 IACET CEU's for this program. [atsdr.cdc.gov]
Prevention Eliminating exposure to beryllium is the surest way to prevent berylliosis. [encyclopedia.com]
How can we prevent beryllium disease? Workplaces need to identify sources of beryllium. In addition to the health hazards described above, beryllium is also a flammable solid and a dust explosion hazard. [ccohs.ca]
Prevention and screening of individuals at risk is important. [dovemed.com]