We found no difference in clinical presentation or in clinical outcome between these two groups. [academic.oup.com]

Session 4 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop focused on case presentations of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (pre-T ALL/LBL) and acute biphenotypic leukemia. [mdanderson.influuent.utsystem.edu]

The most common aberration noted to be present is the Philadelphia chromosome ( BCR-ABL1 ) or t(9;22)(q34;q11.2). [path.upmc.edu]

Unlike common AML, the majority of TdT-positive cases demonstrated an abnormal karyotype with duplications and/or deletions present in all cases. In no instance was trisomy 8, t(8;21), t(15;17), or any other isolated translocation identified. [ncbi.nlm.nih.gov]

• Fatigue

  I decided to put off college due to fatigue and lack of concentration because of chemobrain. Shortly after starting college I developed a chloroma. I dropped two of my classes in order to go to daily radiation. [csn.cancer.org]

  Clinical features include symptoms and complications caused by cytopenias, i.e., fatigue, infections, and bleeding disorders. Possible causes Similar to other acute leukemias the aetiology is unknown. [wiki.clinicalflow.com]

  · Blasts at least 20% · Monocytic cells at least 20% of cells in bone marrow · Elevated circulating monocytes (usually above 5 x 10 9 /L) · 15-25% of all AMLs · Median age: 50 years · Male-to-female ratio 1.4:1 · Anemia, thrombocytopenia, fever, fatigue [hemepathreview.com]

  /11 with c/o fever 1 month duration intermittent fever initially,then she had continuous fever,low grade,not asssociated with chills or rigors h/o swelling over left leg 10 days duration associated with pain constant pain limiting movements h/o easy fatiguability [slideshare.net]

  The most common are: Weight loss Fatigue Fever Night sweats Loss of appetite Other symptoms—such as low numbers of normal blood cells—will be found only when your doctor either suspects leukemia or is drawing blood for other tests. [uihc.org]

• High Fever

  A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. [ncbi.nlm.nih.gov]

  A 60-year-old female with high fever and purpura was admitted to our hospital. She suffered from anemia and thrombocytopenia, and blast cells were found in her peripheral blood. [ci.nii.ac.jp]

• Intermittent Fever

  INTERESTING CASE OF DEEP VEIN THROMBOSIS PROF.DR.K.H.NOORUL AMMEN’S UNIT M5 DR.M.ARIVUMANI 2. 20 Year old Miss.Priya admitted on 18/7/11 with c/o fever 1 month duration intermittent fever initially,then she had continuous fever,low grade,not asssociated [slideshare.net]

• Leg Swelling

  While receiving in medical ward Patient had h/o fever h/o breathlessness h/o bleeding pv h/o malena h/o swelling over left leg(swelling decreased,pain subsided) 12. [slideshare.net]

• Hemoptysis

  A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. [ncbi.nlm.nih.gov]

• Cyanosis

  Examination Patient concious,irritable Severe pallor + Dyspnoeic,tachypnoeic Sternal tenderness + No cyanosis,no clubbbing,no icterus No lymphadenopathy 13. [slideshare.net]

• Vascular Disease

  Source: Department of Vascular Diseases, Institute of Pathological Physiology, Palacky University, Czech Republic. [slideshare.net]

• Palpitations

  H/o body pain + No h/o joint pain No h/o breathlessness No h/o palpitation No h/o chest pain,syncope No h/o abdominal distension,pain No h/o easy bruisability,rashes No h/o bleeding tendencies on admission No h/o trauma 5. [slideshare.net]

• Homans' Sign

  Systemic examination CVS- S1S2 Heard systolic murmur + RS-NVBS heard.no added sounds P/A-soft CNS-NFND L/E of left leg-swelling of left leg +,tender homans sign + 9. With the above clinical profile pt got admitted in vascular surgery dept. [slideshare.net]

• Liver Dysfunction

  Cholestatic liver dysfunction arose, and she died of cachexia and intracranial hemorrhage. Autopsy showed unusual hepatic fibrosis. In the liver, bridging infiltration, bridging necrosis and bridging fibrosis by leukemic cells were seen. [ncbi.nlm.nih.gov]

• Sternal Tenderness

  Examination Patient concious,irritable Severe pallor + Dyspnoeic,tachypnoeic Sternal tenderness + No cyanosis,no clubbbing,no icterus No lymphadenopathy 13. [slideshare.net]

• Eczema

  September 19, 2017 Honored Kid Ava struggled with eczema and severe, life threatening allergies for most of her life. Then, at 5 years old, Ava was diagnosed with biphenotypic leukemia, a rare form of childhood cancer. [stbaldricks.org]

• Skin Lesion

  Mature phenotype (TdT and CD34 negative) Immature phenotype (usually TdT+, sometimes CD34+) Translocation involving myc gene No myc translocation CD4+ CD56+ Hematodermic Neoplasm (Blastic NK Cell Lymphoma) Precursor T Lymphoblastic Leukemia / Lymphoma Skin [surgpathcriteria.stanford.edu]

• Suggestibility

  Those cells got a lot of different suggested classifications by the two groups. Suggested classifications: Metamyelocyte, Myelocyte, Promyelocyte, Promonocyte, Lymphocyte, Lymphocyte variant from, Monocyte, Large granular lymphocyte. [blog.cellavision.com]

  ABL gene amplification and NOTCH 1 gene mutations in subsets of pre-T ALL/LBL suggest patients may benefit from therapy with tyrosine kinase and γ-secretase inhibitors, respectively. [mdanderson.influuent.utsystem.edu]

  The authors therefore suggest that immunophenotyping, when combined with cytochemical analysis of TdT and myeloperoxidase or Sudan black B, may aid in the characterization of subgroups of atypical acute leukemia, such that alternate approaches to therapy [ncbi.nlm.nih.gov]

• Paresis

  Wells Probability score for DVT 2 DVT likely Clinical features points Active cancer 1 Paralysis,paresis,recent immobilisation of lower extremities 1 Localised tenderness along deep venous system 1 Entire leg swollen 1 Calf swelling>3cm larger than asymptomatic [slideshare.net]

Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology. Arch Pathol Lab Med. 2017 Feb 22. [Medline]. [Full Text]. Tsao L, Draoua HY, Osunkwo I, et al. [emedicine.medscape.com]

We did not have markers (CD24, CD1A, CD65, CD15, and CD64) as recommended in the EGIL criteria for a complete workup, for diagnosis of BAL. This may be a cause of lower percentages of BAL. [indianjcancer.com]

• Pulmonary Infiltrate

  IPA must be considered in immunocompromised patients with pulmonary infiltrates who do not respond to broad-spectrum antibiotics. [ncbi.nlm.nih.gov]

• Karyotype Abnormal

  Instead, a variety of nonrandom karyotypic abnormalities were seen, including trisomy 13. Unlike common AML, the majority of TdT-positive cases demonstrated an abnormal karyotype with duplications and/or deletions present in all cases. [ncbi.nlm.nih.gov]

  karyotype in 56% of cases. [mycology.imedpub.com]

  karyotypes (29/33 in total), with the most common being abnormalities of chromosomes 5 or 7 followed by 12p abnormalities. [nature.com]

  Complex karyotypes with multiple structural abnormalities are common. [northshore.org]

Serological tests and CT findings can aid in early diagnosis of IPA, which, along with treatment for IPA, will improve clinical outcomes. [ncbi.nlm.nih.gov]

Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome [books.google.com]

Knowledge of its treatment is limited to retrospective analyses of small patient cohorts. So far, no treatment recommendations verified by prospective studies have been published. [biomed.papers.upol.cz]

The number of longitudinal nutritional studies during treatment, however, is limited. [scinapse.io]

There is limited data available regarding the clinico-hematological profile, treatment protocols, and treatment outcome in patients with BAL. [indianjcancer.com]

They can be either de novo or therapy related, and often have a poor prognosis. Flow Diagnosis [wiki.clinicalflow.com]

Prognosis - Biphenotypic acute leukaemia The prognosis of BAL in adults is worse than acute myeloid leukaemia (AML) or acute lymphoid leukaemia (ALL). Four year overall survival has been quoted at 8%, although the numbers in this study are low. [checkorphan.org]

[…] and treatment Poor, overall survival of 18 months Young age, normal karyotype and ALL induction therapy are associated with favorable survival Ph+ is a predictor for poor prognosis Bone marrow transplantation should be considered in first remission MPAL [pathologyoutlines.com]

HOX11 overexpression may correlate with a good prognosis in adult pre-T ALL. [mdanderson.influuent.utsystem.edu]

Data are emerging that BAL has a negative prognosis in both children and adults and this may be related to the underlying chromosome abnormalities. [ncbi.nlm.nih.gov]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

[…] of a 4-year-old boy with no relevant history; in August 2014 he debuted with multiple painless lymphadenopathy, initially being studied by the Department of Infectious Diseases from Edgardo Rebagliati Martins National Hospital discarding infectious etiology [clinmedjournals.org]

· Epidemiology: · Etiology: unknown, possible causes: environmental toxins and radiation exposure · Clinical features o Related to bone marrow failure: fatigue, infections, bleeding · Morphology o Acute undifferentiated leukemia § Leukemic cells lack [hemepathreview.com]

Epidemiology : biphenotypic acute leukemias may affect adults or children, particularly infants under 2 years old. [ufrgs.br]

Epidemiology These rare leukemias account for less than 4% of all cases of acute leukemia and occur in all age groups but are more frequent in adults. [wiki.clinicalflow.com]

[…] with no evidence of myeloid differentiation by § Morphology, and Light microscopic cytochemistry o Myeloid nature of blasts demonstrated by § Immunologic markers, and/or § Ultrastructural studies o Immunophenotyping studies essential to rule out ALL · Epidemiology [hemepathreview.com]

See also the following: Epidemiology Acute undifferentiated leukemia (AUL) is extremely rare, and little is known about the frequency of this disease. [emedicine.medscape.com]

[…] lymphoblastic leukaemia/lymphoma, NOS ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS ICD-Morpho 9920/3 Therapy-related myeloid neoplasms Atlas_Id 1214 Epidemiology [atlasgeneticsoncology.org]

This cell line, MY, expressing a novel variant P180BCR/ABL protein with a deletion of the a2 exon of the ABL gene, may be useful for elucidating the pathophysiology of this fusion protein and for studying ETV6-related leukemogenesis and t(2;3), as well [ncbi.nlm.nih.gov]

[…] examination to diagnose leukemia was first described in 1879 by Mosler. [5] Finally, in 1900 the myeloblast, which is the malignant cell in acute myeloid leukemia, was characterized by Naegeli, who divided the leukemias into myeloid and lymphocytic. [6] [7] Pathophysiology [wikidoc.org]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]

Prevention - Biphenotypic acute leukaemia Not supplied. Diagnosis - Biphenotypic acute leukaemia Not supplied. [checkorphan.org]

Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin 2 Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention Recruiting NCT01951885 Phase 3 tacrolimus [malacards.org]