Poor-risk cytogenetics were present in 61% of the erythroleukemia patients and 38% of the control patients. Complete remission rates were 62% in the erythroleukemia group and 58% in the control group. [emedicine.com]

The most common cytogenetic abnormality was a complex karyotype, present in 49 patients (54%), including 40 (44%) patients who presented with abnormalities of chromosomes 5 and/or 7. Isolated trisomy 8 was present in 5.5% of cases. [nature.com]

[…] at least 20% myeloblasts in the bone marrow Acute erythroid leukemia characterised by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present [icd9data.com]

• Hemophilia A

  A, congenital factor VIII disorder 286.1 Hemophilia B, congenital factor IX disorder 289.89 Hypercoagulable state, unspecified 289.89 Hypergammaglobulinemia 280.9 Iron deficiency anemia, unspecified 288.60 Leukocytosis/leucocytosis V58.61 Long-term [hemonc.org]

• Anemia

  […] treatment for anemia groups. [doi.org]

  […] with excess blasts and preceding or concurrent history of erythropoietin therapy for anemia (n=16). [ncbi.nlm.nih.gov]

  acute blood loss 280.0 Anemia due to GI blood loss 285.21 Anemia in end-stage renal disease (ESRD) 285.22 Anemia in neoplastic disease 280.9 D50.9 Anemia, iron deficiency, unspecified 281.9 Anemia, macrocytic 285.29 D63.8 Anemia of chronic disease 285.9 [hemonc.org]

  Severe anemia is a common symptom. This leukemia usually follows an aggressive clinical course. [icd9data.com]

• Falling

  D75.1 Secondary polycythemia 2016 2017 2018 2019 Billable/Specific Code Applicable To Acquired polycythemia Emotional polycythemia Erythrocytosis NOS Hypoxemic polycythemia Nephrogenous polycythemia Polycythemia due to erythropoietin Polycythemia due to fall [icd10data.com]

  PubMed CrossRef Google Scholar Marti, H.R., Vetter, H. : Akute Erythrämie; Diagnose und Differentialdiagnose eines klinisch und autoptisch beobachteten Falles. Schweiz, med. Wschr. 87, 1231 (1957). [link.springer.com]

  […] site 536.8 Dyspepsia 787.20 Dysphagia, unspecified 787.21 Dysphagia, oral phase 787.22 Dysphagia, pharyngeal phase 786.09 Dyspnea 780.94 Early satiety 782.3 Edema NOS 530.10 Esophagitis 381.81 Eustachian tube dysfunction 783.7 Failure to thrive E888.9 Fall [hemonc.org]

  His Hb continued to fall and by August 1998 he had become transfusion dependent. Repeat bone marrow examination at that time showed refractory anaemia with no excess of blasts. [jcp.bmj.com]

  Am J Pediatr Hematol Oncol 1989, Fall 11 : 348–359. 16. Lazure T, Beauchamp A, Croisille L, Ferlicot S, Feneux D, Fabre M. Congenital anerythremic erythroleukemia presenting as hepatic failure. Arch Pathol Lab Med 2003; 127 : 1362–1365. 17. [nature.com]

• Weight Loss

  Almost half of people with AEL exhibit weight loss, fever and night sweats at the time of diagnosis. Almost all people with AEL are anemic, and 77% have a hemoglobin level under 10.0 g/dl. [en.wikipedia.org]

  […] gain 783.21 Weight loss 786.07 Wheezing, NOS Psychiatric 300.00 Anxiety state 296.80 Bipolar disorder, unspecified 301.83 Borderline personality disorder 311 Depression, NOS 309.0 Depressive reaction, acute/situational 303.90 Drug use/dependence, alcohol [hemonc.org]

  Symptoms of AML include: Fever Shortness of breath Easy bruising or bleeding Bleeding under the skin Weakness or feeling tired Weight loss or loss of appetite Tests that examine the blood and bone marrow diagnose AML. [fpnotebook.com]

  Over the previous six months he had developed progressive tiredness, bilateral leg swelling, weight loss, and night sweats and, more recently, had noted epistaxis, haemoptysis, and central chest tightness at rest. [jcp.bmj.com]

• Trisomy 21

  SOM is common in those with syndromic conditions, such asTreacher-Collins and Trisomy 21 and abnormalities such as cleft palate and immotile cilia syndrome. [app1.unmc.edu]

  The child with Down's syndrome had trisomy 11 in addition to his constitutional trisomy 21. Analysis failed in three patients. The remaining patients had trisomy 8, loss of the long arm of chromosome 9, loss of the long arm of chromosome 11. [doi.org]

• Nausea

  […] only 787.01 Nausea and vomiting 356.9 Neuropathy, unspecified idiopathic peripheral neuropathy 786.02 Orthopnea 715.90 Osteoarthritis, unspecified site 733.90 Osteopenia 733.00 Osteoporosis, unspecified site 729.5 Pain in limb 789.06 Pain, abdominal-epigastric [hemonc.org]

  Occasionally patients, especially children, present with systemic symptoms of nausea, vomiting, and headache. Symptoms of non-group A, such as group C or G, streptococcal pharyngitis are very similar to GAS and clinically indistinguishable. [internalmedicinejournal.blogspot.com]

  Acute Diffuse Glomerulonephritis (UMLS (NCI) C0341689) =Disease or Syndrome 4. acupressure [The application of pressure or localized massage to specific sites on the body to control symptoms such as pain or nausea. [medindex.am]

• Diarrhea

  […] was an important cause in the past, but it has decreased dramatically as a cause for erythema nodosum; however, it still must be excluded, especially in developing countries. [5, 6] Yersinia enterocolitica is a gram-negative bacillus that causes acute diarrhea [emedicine.medscape.com]

  008.45 Diarrhea, C. diff (Clostridium difficile) 719.7 Difficulty in walking 453.9 I82.91 Deep vein thrombosis (DVT), unspecified site 536.8 Dyspepsia 787.20 Dysphagia, unspecified 787.21 Dysphagia, oral phase 787.22 Dysphagia, pharyngeal phase 786.09 [hemonc.org]

Immunohistochemistry has a role in the workup of cases of AEL, particularly in cases in which the aspirate material is scant. Here we mention markers or applications not already addressed in the flow cytometry section above. [archivesofpathology.org]

• Erythroblast

  […] remission Acute Erythroblastic Leukemia Acute myeloid leukemia M6 Di Guglielmo syndrome AEL M6 Acute Myeloid Leukemia Di Guglielmo's syndrome AML M6 Erythroblastic Leukemia Fab M6 AML-M6 Acute erythroleukemia M6b subtype Acute Erythroid Leukemia Erythroleukemia [wikidata.org]

  (who, 2001) Myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood Applies To Acute erythremic myelosis Di Guglielmo's disease [icd9data.com]

  At lower left is any erythroblast with a band neutrophil above it. [meds.com]

  The erythroid component consists predominantly or exclusively of proerythroblasts and early basophilic erythroblasts. These cells may constitute 90% or more of the marrow elements. [en.wikipedia.org]

  Determining the myeloblast-to-erythroblast ratio at diagnosis helps to predict prognosis; a higher ratio is associated with a favorable prognosis. [emedicine.com]

Problems encountered in the treatment of acute erythroleukemia include primary induction failure, relapse, and the toxicity of chemotherapeutic agents. [emedicine.com]

No treatment group was predictive of worse DFS by multivariate analysis. [nature.com]

Prognosis is worse in elderly patients, those with a history of myelodysplastic syndrome, and in patients who had previously received chemotherapy for the treatment of a different neoplasm. [en.wikipedia.org]

Multidrug resistant phenotype (positive Pgp expression) is associated with a poor prognosis. Determining the myeloblast-to-erythroblast ratio at diagnosis helps to predict prognosis; a higher ratio is associated with a favorable prognosis. [emedicine.com]

Information on prognosis is limited by the rarity of the condition. Prognosis appears to be no different to AML in general, taking into account other risk factors. Acute erythroid leukemia (M6) has a relatively poor prognosis. [en.wikipedia.org]

The prognosis of this patient subset is relatively good. The other subset has cytogenetic abnormalities similar to those in myelodysplastic syndromes and a poor prognosis. [ncbi.nlm.nih.gov]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

The etiology of pharyngitis remains obscure in 40% of cases. Most pharyngitis occurs as result of respiratory or contact transmission; few cases are foodborne. [internalmedicinejournal.blogspot.com]

All evaluation is necessarily offered with the reservations that must be held regarding a rare disease of unknown etiology. [bloodjournal.org]

Feline leukemia virus has been implicated in the etiology. blast form of erythremic myelosis previously called reticuloendotheliosis, the predominant cell type is more primitive. [medical-dictionary.thefreedictionary.com]

DIC syndrome can be classified according to etiological, pathogenetic and clinical principles. 13.3.1. Etiological Thrombocytosis Thrombocytosis is divided into primary (tumor, essential) and secondary (reactive and developing after splenectomy). [en.medicine-guidebook.com]

We discuss the differential diagnosis and classification of erythroid neoplasias based upon reproducible hematological criteria to facilitate the gathering and comparison of epidemiological and clinical data on these rare malignancies. [ncbi.nlm.nih.gov]

We discuss the differential diagnosis and classification of erythroid neoplasias based upon reproducible hematological criteria to facilitate the gathering and comparison of epidemiological and clinical data on these rare malignancies. © 1987 S. [karger.com]

01, 2015) Signs and Symptoms Anemia Circulating erythroblasts Easy bruising or bleeding Fatigue Fever Petechiae Shortness of breath Weakness Diagnostic Exams Immunophenotyping Lumbar puncture Peripheral blood smear Progression and Transformation None Epidemiology [seer.cancer.gov]

The PACE (population-adjusted clinical epidemiology) strategy: a new approach to multicentre clinical research. QJM 1997 ; 90 : 147 –51. ↵ Office of Population Censuses and Surveys. The 1991 Census on CD-ROM. [doi.org]

Overlapping SJS and TEN No typical targets, flat atypical targets 10 to 30 TEN No typical targets, flat atypical targets; begins with severe mucosal erosions and progresses to diffuse, generalized detachment of the epidermis Greater than 30 Etiology and Pathophysiology [aafp.org]

Prevention & Control Active immunization plays a role in prevention with regard to diphtheria and influenza types A and B (Box 9-4). Tonsillectomy is recommended in selected patients. [internalmedicinejournal.blogspot.com]

[…] national prevention strategies. [ceub.it]

B 29 Continuous acyclovir is recommended to prevent recurrent herpes-associated erythema multiforme. [aafp.org]

Acupuncture for anesthesia [Use of ACUPUNCTURE to block the afferent nerve impulses from reaching the brain to reduce the sensation of pain for surgery. ( MSH )] (UMLS (ICD9CM) C0001301) =Therapeutic or Preventive Procedure ; 56. [medindex.am]

[…] discomfort Mouthwashes to ease discomfort of mouth sores that interferes with eating and drinking Antibiotics for skin infections Corticosteroids to control inflammation Medicines for eye symptoms Good hygiene and staying away from other people may help prevent [medlineplus.gov]