Presentation
It was considered that aggresive exercise performed under hot environment led to acute rhabdomyolysis and subsequent acute renal failure in the present case. [jstage.jst.go.jp]
None of present ultra-athletes showed post-race hypokalemia. Present case 1 developed post-race plasma [K + ] 5.2 mmol/l and case 2 plasma [K + ] of 4.6 mmol/l. [healthdocbox.com]
Patient presentations All forms of rhabdomyolysis can present as a “classic triad” of muscle pain, weakness and dark urine, however less than 10% of patients tend to experience all three [2, 3]. [emdocs.net]
The physician should maintain a high index of suspicion for acute exertional rhabdomyolysis in patients who present with symptoms of an overexertion injury, most commonly pain and swelling in the affected muscles. [ncbi.nlm.nih.gov]
[…] studies, genetic testing guillaine-barre syndrome -epidemiology -pathogenesis -etiology -presentation -diags epidem: acute and severe fulminate inflammatory polyradiculoneuropathy *most common acquired demyelinating polyneuropathy, most common cause [quizlet.com]
Entire Body System
- Swelling
The physician should maintain a high index of suspicion for acute exertional rhabdomyolysis in patients who present with symptoms of an overexertion injury, most commonly pain and swelling in the affected muscles. [ncbi.nlm.nih.gov]
Albumin is rarely indicated for the treatment of hypoalbuminemia since it may leak into the interstitial space and cause muscle swelling to worsen. [drplace.com]
Symptoms of rhabdomyolysis include muscle pain, weakness and swelling; myoglobinuira (presence of myoglobin in the urine); and increased levels of muscle enzymes and other muscle constituents in the blood.” 2. [bsmpg.com]
However, people experiencing AER usually present with a triad of symptoms including: severe muscle soreness, significant muscle swelling, and cola-colored urine. [columbusgeorgiaonline.com]
By that evening, her slender arms had continued to swell into plump hotdogs of ache and regret, and she was starting to come to the realization that the morning’s danger alarms were legitimate. [medium.com]
- Fever
Paracetamol, also known as acetaminophen or apap, is a medicine used to treat pain tylenol for fever with stomach virus flu side effects">tylenol cold and flu side effects and fever. Hyldahl, Justin Keadle, Pierre. [vnezapil.com]
Continued Other common signs of rhabdomyolysis include: Abdominal pain Nausea or vomiting Fever, rapid heart rate Confusion, dehydration, fever, or lack of consciousness Blood tests for creatine kinase, a product of muscle breakdown, and urine tests for [webmd.com]
He was found to be normotensive, without fever, presenting serious oedemas in lower limbs and with oliguria. [revistanefrologia.com]
In addition, fever, fasting and stress can induce symptoms. Symptoms are not triggered by isometric contraction in people with fatty acid metabolism dysfunction. [ojrd.biomedcentral.com]
Constitutional symptoms vary on the cause; the most common are generalised malaise, fever and nausea. The associated electrolyte disturbance can lead to agitation and confusion. [patient.info]
- Falling
Prevention • During the first few days of training camp or return to school (either summer training or fall classes) never begin your program with repetitive, excessive exercise. [bsmpg.com]
In the first category, causes include: A crush injury such as from an auto accident, fall, or building collapse Long-lasting muscle compression such as that caused by prolonged immobilization after a fall or lying unconscious on a hard surface during [webmd.com]
[…] triggered by head position changes central: uni/bi-direction nystagmus, spinning sensation and falling/leaning diag: vestibular fcn tests, hallpike test, balance testing, MRI (for central), MRA (for vascular) fluctuating and progressive sensorineural [quizlet.com]
Minicore (multicore) myopathy Minicore (multicore) myopathy Minicore myopathy, also called, multicore myopathy and multiminicore myopathy, falls under the umbrella of congenital myopathies. [docplayer.net]
Related Infographics Recommended Content: Health Readiness | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101 Some documents are presented [health.mil]
- Military Personnel
A number of high-profile deaths among athletes and military personnel involving exertional rhabdomyolysis have been attributed to sickle cell trait. The National Collegiate Athletic Association, the U.S. Air Force, and the U.S. [mdedge.com]
Another report in 1960 cited 60 marine recruits who sought medical attention during a period of one year because of pigmenturia and muscle pain associated with exertion.(4) Awareness of this syndrome among military personnel increased in 1971 when 40 [drplace.com]
Exertional rhabdomyolysis is well described among athletes and military personnel, but may occur in anybody exposed to unaccustomed exercise. [bmjopensem.bmj.com]
This syndrome has received considerable attention because of high-profile deaths involving exertional rhabdomyolysis in athletes and military personnel. 1-10 A number of such cases have been attributed to sickle cell trait, 11-15 a condition in which [nejm.org]
These problems have been recognized among military personnel, long-distance runners, and other athletes (2-6). However, exercise-related rhabdomyolysis and renal impairment have not been previously described in the groups involved in this report. [cappaa.com]
- Weight Gain
Although useful, it is a measure that should be taken with caution due to the high level of calories, which can result in an excessive weight gain. 8 Vitamin B6 supplements were also found to be beneficial in case of McArdle’s disease, but needs to be [revistanefrologia.com]
Isto significa que a dose normal prxima da infant tylenol dosage by weight gain dose em que se considera haver sobredosagem, tornando-o um frmaco relativamente perigoso. 94 (1 2938 «Um Festival de Analgsicos». [vnezapil.com]
Cardiovascular
- Thrombosis
The risk for rhabdomyolysis and/or acute renal impairment after taking the test was increased in candidates with an underlying medical condition (e.g., pneumonia or renal vein thrombosis) (odds ratio (OR)=10.3; 95% confidence interval (CI)=2.5-43.6). [cappaa.com]
Musculoskeletal
- Myopathy
Minicore (multicore) myopathy Minicore (multicore) myopathy Minicore myopathy, also called, multicore myopathy and multiminicore myopathy, falls under the umbrella of congenital myopathies. [docplayer.net]
Myopathy presenting as a sole manifestation of hypothyroidism. J Assoc Physicians India 58: 569, 2010. CAS PubMed Google Scholar McKeran RO, Slavi G, Ward P, Paul E, Mair W. Hypothyroid myopathy. A clinical and pathological study. [link.springer.com]
Called also azoturia, Monday morning disease, tying up syndrome, capture myopathy. rhabdomyolysis disintegration of striated muscle fibers with excretion of myoglobin in the urine. exertional rhabdomyolysis transient exertional rhabdomyolysis [medical-dictionary.thefreedictionary.com]
Recessive mutations in ANO5 (OMIM#608662) cause a wide spectrum of myopathies including LGMD2L, distal myopathy and isolated hyperCKemia. [ojrd.biomedcentral.com]
However, the results of myopathological changes and tandem mass spectrometry were not consistent with ischemic myopathy. [zdoc.site]
- Myalgia
The myalgia improved progressively until it disappeared. [revistanefrologia.com]
Results: Among 43 players, 22 (51%) experienced rhabdomyolysis (peak creatine kinase range, 2434-42 000 U/L): 22 patients had upper arm myalgia; 12 were hospitalized; 3 experienced triceps compartment syndrome; none experienced renal failure. [stacks.cdc.gov]
A 62-year-old man was brought to the hospital with back pain and muscle weakness accompanied by myalgia. These symptoms developed 20 h after he had consumed his last meal which included the wild mushroom Russula subnigricans. [blog.goo.ne.jp]
RM and myalgia may be the dominating symptom in a few cases of LGMD2I [ 82 ]. [ojrd.biomedcentral.com]
There was no correlation whatsoever between CK levels and the amount of exertion, environmental conditions, or myalgia, or weakness. [bmjopensem.bmj.com]
- Muscle Weakness
The muscle weakness persisted for over a week. The maximal serum creatine kinase activity was 42,689 U/L. [blog.goo.ne.jp]
Two patients who demonstrated increased muscle mass, muscle stiffness with variable degrees of muscle weakness and low levels of serum thyroxine (Hoffmann's syndrome) are described. [scinapse.io]
The “classic triad” of rhabdomyolysis symptoms are: muscle pain in the shoulders, thighs, or lower back; muscle weakness or trouble moving arms and legs; and dark red or brown urine or decreased urination. [webmd.com]
Patients with McArdle’s disease present intolerance to shortterm exercise and cramps or muscle weakness especially as in the case of our patient when he was subjected to short and frequent periods of physical exercise through the use of an electrostimulator [revistanefrologia.com]
[…] serum CK levels NM transmission disorder Affects women more, usually in 20-30s Affects men in 50-60s relatively common Decrease Ach receptors in postsynaptic membrane, antiAChR antibodies fatiguable weakness of SK muscle weakness begins in face muscles [quizlet.com]
- Muscle Swelling
However, people experiencing AER usually present with a triad of symptoms including: severe muscle soreness, significant muscle swelling, and cola-colored urine. [columbusgeorgiaonline.com]
Albumin is rarely indicated for the treatment of hypoalbuminemia since it may leak into the interstitial space and cause muscle swelling to worsen. [drplace.com]
Examination showed tenderness and swelling in both arms and thighs muscle groups. Movements were painful. There was no ecchymosis and no sensory or motor deficit of the limbs. Distal pulsations were normal. [mjdrdypu.org]
[…] direct pressure causes muscle cells to become ischemic. [tycodes.cf]
[…] causes muscle cells to become ischemic. [sordtss.ga]
- Muscle Tenderness
When present, muscle pain is typically found in the proximal muscles such as the shoulders and thighs [2]. Patients may have muscle weakness, cramping, stiffness and tenderness on palpation to muscles during physical exam. [emdocs.net]
Neurologic
- Vertigo
More obvious in quiet pulsatile- pulsatile sounds diag- audiometric testing, MRI/CT to rule out structural/neoplasms vertigo: peripheral/central symptoms and diag most common vestibular disorder mismatch between vestibular, somatic sensory, visual systems [quizlet.com]
- Tremor
[…] lead to this disease include: Trauma or crush injuries Use of drugs such as cocaine, amphetamines, statins, heroin, or PCP Genetic muscle diseases Extremes of body temperature Ischemia or death of muscle tissue Low phosphate levels Seizures or muscle tremors [medlineplus.gov]
Urogenital
- Dark Urine
CASE 1 A 30-year-old man, who at the age of 14 suffered from episodes of acute myalgia and from dark urine due to prolonged physical exercise (walking 6-7 kilometres.) No family member showed similar episodes. [revistanefrologia.com]
Myoglobin in the urine causes your urine to become dark in color similar to cola. “In rare cases, myoglobin can precipitate in the kidneys and cause renal failure” and ultimately death. 3. [bsmpg.com]
This morning, his urine was dark red-brown. Yesterday, he completed a lifting workout which included bench pressing and pushups. [emdocs.net]
They should alert coaches or athletic trainers if they develop any of the signs, such as muscle pain and swelling and dark urine. If there is a question, they should go to a hospital emergency department for evaluation and possible treatment. [drdavidgeier.com]
Myoglobinuria is revealed by urinalysis and is characterized by dark color of urine, heme-positive dipstick and the absence of red blood cells under microscopic examination. [drplace.com]
- Red Urine
- By the way, the answer to the above question is muscle pain, weakness, and brown/red urine. [pictaramci.com]
This morning, his urine was dark red-brown. Yesterday, he completed a lifting workout which included bench pressing and pushups. [emdocs.net]
- Incontinence
[…] underline the point, MoveForwardPT.com, the official consumer information website of the American Physical Therapy Association (APTA), hosted an online radio show specifically responding to CrossFit’s irresponsible glorification of stress induced urinary incontinence [medium.com]
Workup
A minimallaboratory workup in rhabdomyolysisincludes serum levels o CK, calcium,electrolyte renal unctions, in conjunc-tion with detection o myoglobin inurine and an electrocardiogram. [usdocument.net]
Note that depending on clinical picture, further workup regarding each of the following potential complications may be warranted. For example, neuroimaging is not generally performed in the setting of EHS. [emdocs.net]
[…] in significantly higher frequencies in patients who presented with severe episodes of ERM. 60 However, in the reported study, the authors did not specify the other genetic causes of rhabdomyolysis that had been investigated as part of the diagnostic workup [bmjopensem.bmj.com]
Magnetic resonance imaging (MRI; assessment of myopathy) Other tests that may be considered include the following: Electrocardiography (ECG) Measurement of compartment pressures Muscle biopsy Immunoblotting, immunofluorescence, and genetic studies See Workup [emedicine.medscape.com]
Treatment
Practical, bulleted, highly templated text with easy-to-use features including flow charts and treatment boxes. [books.google.com]
A 28-year-old man on thyroid hormone replacement following treatment with radioactive iodine for Graves' disease developed an episode of acute exertional rhabdomyolysis. [ncbi.nlm.nih.gov]
Rhabdomyolysis Treatments Early diagnosis and treatment of rhabdomyolysis and its causes are keys to a successful outcome. You can expect full recovery with prompt treatment. Doctors can even reverse kidney damage. [webmd.com]
Treatment The treatment of rhabdomyolysis is determined on an individual basis that is constructed on the severity and identified cause of this condition. Once the cause is identified, the treatment will be specific to the case presented. [kon.org]
Albumin is rarely indicated for the treatment of hypoalbuminemia since it may leak into the interstitial space and cause muscle swelling to worsen. [drplace.com]
Prognosis
Regardless, research agrees that with prompt diagnosis and medical intervention, the prognosis for full recovery after suffering from AER is good, making it is essential for all health professionals to be able to recognize signs and symptoms of AER and [columbusgeorgiaonline.com]
Taiwan (3) Renal Division, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, No.168, Jhongsing Road, Longtan Township, Taoyuan County, 32551, Taiwan References Imazio M, Trinchero R: Myopericarditis: etiology, management, and prognosis [bmcinfectdis.biomedcentral.com]
The ability to identify these patient early in the course of a rhabdomyolysis episode is useful for early institution of aggressive prophylactic measures, admission to the ward or intensive care unit, and communication with patients and families about prognosis [bmjopensem.bmj.com]
The prognosis in rhabdomyolysis is significantly worse if AKI is present [21]. While the data on mortality varies with cause of rhabdomyolysis and AKI, studies have shown that in all causes, AKI increases the likelihood of mortality. [emdocs.net]
Etiology
(top down), proximal in distribution patients can ambulate can have bulbar symptoms decreased DTR diagnosis- muscle biopsy (to rule out primary muscle), nerve conduction studies, genetic testing guillaine-barre syndrome -epidemiology -pathogenesis -etiology [quizlet.com]
The underlying etiology of this catastrophic presentation of adolescent diabetes mellitus is unclear. [emedicine.medscape.com]
Diagnosis With many etiological factors that may produce the onset of rhabdomyolysis, proper diagnosis is important in order to determine appropriate forms of treatment. [kon.org]
Table 1 Etiologies of viral myopericarditis Coxsackievirus * Parainfluenza Adenovirus Human immunodeficiency virus Cytomegalovirus Varicella Echovirus Mumps Influenza * Rubeola Epstein–Barr virus Rubella Herpesvirus Poliomyelitis Hepatitis virus Rhinovirus [bmcinfectdis.biomedcentral.com]
DISCUSSION In 1941 it was performed the first detailed description of rhabdomyolysis. 1 Since then, numerous cases report has been published and it has been known a growing list of possible etiologies 2 (table 1.) [revistanefrologia.com]
Epidemiology
Air Force photo) Related Infographics Recommended Content: Health Readiness | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health Anopheles merus mosquito. [health.mil]
Study Design: Descriptive epidemiology study. [stacks.cdc.gov]
Epidemiologic aspects of the Bam earthquake in Iran: the nephrologic perspective. Am J Kidney Dis. 2006;47(3):428. Gunal AI, Celiker H, Dogukan A, Ozalp G, Kirciman E, Simsekli H, Gunay I, Demircin M, Belhan O, Yildirim MA, Sever MS. [gacetamedicaboliviana.com]
"Blood Pressure" [SH] (epidemiology AND humans) [SH] SI Secondary Source ID The SI field identifies secondary source databanks and accession numbers, e.g., GenBank, GEO, PubChem, ClinicalTrials.gov, ISRCTN. [biomedsearch.com]
Epidemiology Incidence figures are not available for the general population, but screening of 337 military recruits for myoglobin serum levels, showed rhabdomyolysis in 40%. [ 6 ] It is more common in men, particularly well-educated professionals, who [patient.info]
Pathophysiology
This article reviews the definitions, pathophysiology, diagnosis, and management of ER with specific relevance to acute kidney injury. [ncbi.nlm.nih.gov]
Pathophysiology of ERM Reports of RM date back thousands of years (Vanholder et al. 2000). [ideafit.com]
Research Educational research and school practice Culture and Cultural Practice Lived Religion and Religious Practice in Ever General Pathology and Clinical Medicine Pharmacology and Clinical pharmacy Yoruba and Ifa practice Physiology and clinical pathophysiology [allslide.net]
However, they may in fact be pathophysiologically related under certain circumstances. [bmcinfectdis.biomedcentral.com]
Several studies have described the pathophysiology of diminished renal functi... more Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle contents into the systemic circulation. [scinapse.io]
Prevention
Early intervention with aggressive hydration and close monitoring for metabolic, renal or hematologic complications may prevent serious injury or death. [ncbi.nlm.nih.gov]
In such cases, early fasciotomy may be necessary to prevent further necrosis and gangrene.(1) Treatment Early fluid replacement is the key to managing acute exertional rhabdomyolysis. [drplace.com]
Although the possibility of someone having exertional rhabdomyolysis is low, it is best to be well-versed in the causes, the signs and symptoms, and what to do in order to prevent this from happening! Dr. [mp-body.com]
An Ounce of Prevention. [bsmpg.com]
Can it be prevented? While rare, exertional rhabdomyolysis can develop after intense workouts and other physical activity. While it might not be possible to completely prevent it, some steps might be advisable. [drdavidgeier.com]